{"id":1098,"date":"2021-09-08T17:47:10","date_gmt":"2021-09-08T08:47:10","guid":{"rendered":"https:\/\/yobou.work\/?p=1098"},"modified":"2021-10-14T18:08:12","modified_gmt":"2021-10-14T09:08:12","slug":"%e6%ad%a3%e3%81%97%e3%81%8f%e4%bd%bf%e3%81%88%e3%81%a6%e3%81%84%e3%81%be%e3%81%99%e3%81%8b%ef%bc%9f%e3%83%95%e3%83%83%e5%8c%96%e7%ac%ac%e4%b8%80%e3%82%b9%e3%82%basnf2%e6%ad%af%e7%a3%a8%e5%89%a4","status":"publish","type":"post","link":"https:\/\/yobou.work\/?p=1098","title":{"rendered":"\u3010\u30a8\u30d3\u30c7\u30f3\u30b9\u3011\u30d5\u30c3\u5316\u7b2c\u4e00\u30b9\u30ba(SnF2)\u542b\u6709\u6b6f\u78e8\u5264\u306b\u3064\u3044\u3066\u8abf\u3079\u3066\u307f\u305f"},"content":{"rendered":"<p><img data-recalc-dims=\"1\" decoding=\"async\" class=\"aligncenter size-large wp-image-1102\" src=\"https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2021\/09\/DSC01229.jpg?resize=665%2C499\" alt=\"\" width=\"665\" height=\"499\" srcset=\"https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2021\/09\/DSC01229.jpg?resize=1024%2C768&amp;ssl=1 1024w, https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2021\/09\/DSC01229.jpg?resize=300%2C225&amp;ssl=1 300w, https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2021\/09\/DSC01229.jpg?resize=768%2C576&amp;ssl=1 768w, https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2021\/09\/DSC01229.jpg?resize=1536%2C1152&amp;ssl=1 1536w, https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2021\/09\/DSC01229.jpg?resize=660%2C495&amp;ssl=1 660w, https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2021\/09\/DSC01229.jpg?w=1920&amp;ssl=1 1920w, https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2021\/09\/DSC01229.jpg?w=1330 1330w\" sizes=\"(max-width: 665px) 100vw, 665px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p>\u3000\u30d5\u30c3\u5316\u30ca\u30c8\u30ea\u30a6\u30e0 (NaF)\u3084\u30e2\u30ce\u30d5\u30eb\u30aa\u30ed\u30ea\u30f3\u9178\u30ca\u30c8\u30ea\u30a6\u30e0 (MFP)\uff0c\u3042\u308b\u3044\u306f\u30ea\u30f3\u9178\u9178\u6027\u30d5\u30c3\u5316\u30ca\u30c8\u30ea\u30a6\u30e0(APF)\u3068\u6bd4\u8f03\u3057\u3066\u30d5\u30c3\u5316\u7b2c\u4e00\u30b9\u30ba(SnF<sub>2<\/sub>)\u6b6f\u78e8\u5264\u306e\u60c5\u5831\u306f\u591a\u304f\u3042\u308a\u307e\u305b\u3093\uff0e\u306a\u3093\u3068\u306a\u304f<i>S.mutans<\/i>\u306b\u52b9\u679c\u3042\u308b\u306e\u306f\u77e5\u3063\u3066\u3044\u308b\u3051\u308c\u3069\uff0c\u7740\u8272\u3084\u5473\u306e\u3053\u3068\u3067\u656c\u9060\u3057\u3066\u3044\u305f\u308a\u30fb\u30fb\u30fb\u4eca\u56de\u306f\u305d\u3093\u306a\u30de\u30a4\u30ca\u30fc\u306a\u30d5\u30c3\u5316\u7269\u300c\u30d5\u30c3\u5316\u7b2c\u4e00\u30b9\u30ba\u300d\u306b\u30b9\u30dd\u30c3\u30c8\u3092\u5f53\u3066\u3066\u307f\u305f\u3044\u3068\u601d\u3044\u307e\u3059\uff0e<\/p>\n<p>\u203b \u4eca\u56de\u306f\u6587\u732e\u691c\u7d22\u3067\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u300c\u30da\u30fc\u30b9\u30c8\u300d\u3084\u300c\u30b8\u30a7\u30eb\u300d\u3092\u7dcf\u79f0\u3057\u3066\u300c\u6b6f\u78e8\u5264\u300d\u3068\u547c\u79f0\u3057\u3066\u3044\u307e\u3059\uff0e<\/p>\n<p>&nbsp;<\/p>\n<h2>\uff11\uff0e\u30d5\u30c3\u5316\u7b2c\u4e00\u30b9\u30ba\u914d\u5408\u6b6f\u78e8\u5264\u306e\u30a8\u30d3\u30c7\u30f3\u30b9<\/h2>\n<p>\u3000\u30d5\u30c3\u5316\u7b2c\u4e00\u30b9\u30ba(SnF<sub>2<\/sub>)\u914d\u5408\u6b6f\u78e8\u5264\u306f1950\u5e74\u306bMuhler\u3089\u306b\u3088\u308a\u958b\u767a\u3055\u308c\u305f\u6b6f\u9762\u5857\u5e03\u5264<sup>1)<\/sup>\u3092\u6539\u826f\u3057\u6b6f\u78e8\u5264\u306b\u5fdc\u7528\u3057\u305f\u3082\u306e\u3067\u3059\uff0e\u6b6f\u9762\u5857\u5e03\u5264\u3068\u3057\u3066\u306f\uff0c\uff18\uff05(19,400ppm)\u3084\uff14\uff05(9,700ppm)\u306e\u6c34\u6eb6\u6db2\u304c\u7528\u3044\u3089\u308c\u307e\u3059\u304c\uff0c\u6c34\u6eb6\u6db2\u4e2d\u3067\u306e\u5b89\u5b9a\u304c\u96e3\u3057\u304f\u8abf\u6574\u3057\u3066\u304b\u3089\uff11\u6642\u9593\u4ee5\u5185\u306e\u4f7f\u7528\u304c\u85a6\u3081\u3089\u308c\u308b<sup>2)<\/sup>\u305f\u3081\uff0c\u73fe\u5728\uff0c\u5857\u5e03\u5264\u3084\u6d17\u53e3\u5264\u3068\u3057\u3066\u5546\u54c1\u5316\u3055\u308c\u3066\u3044\u308b\u30d5\u30c3\u5316\u7b2c\u4e00\u30b9\u30ba\u88fd\u5264\u306f\u3042\u308a\u307e\u305b\u3093\uff0e\u73fe\u5728\u306f0.4\uff05\u306e\u30d5\u30c3\u5316\u7b2c\u4e00\u30b9\u30ba\u304c\u914d\u5408\u3055\u308c\u305f\u6b6f\u78e8\u5264\u306e\u307f\u304c\u5e02\u8ca9\u3055\u308c\u3066\u3044\u307e\u3059\uff0e<\/p>\n<p>\u3000\u3046\u8755\u30ea\u30b9\u30af\u56e0\u5b50\u306e\u4e2d\u3067\u30df\u30e5\u30fc\u30bf\u30f3\u30b9\u9023\u9396\u7403\u83cc\u306e\u611f\u67d3\u3068\u83cc\u6570\u304c\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u307e\u3059<sup>3)<\/sup> \u30d5\u30c3\u5316\u7b2c\u4e00\u30b9\u30ba\u3092\u4f7f\u7528\u3057\u305f\u3044\u3068\u3044\u3046\u5834\u5408\uff0c<em>S.mutans<\/em>\u3078\u306e\u4f5c\u7528\u3092\u671f\u5f85\u3057\u3066\u3068\u3044\u3046\u5834\u5408\u304c\u591a\u3044\u3068\u601d\u3044\u307e\u3059\uff0e<em>S.mutans<\/em>\u3084\u30d7\u30e9\u30fc\u30af\u3078\u306e\u52b9\u679c\uff0c\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u3064\u3044\u3066\u3054\u7d39\u4ecb\u3057\u3066\u3044\u304d\u305f\u3044\u3068\u601d\u3044\u307e\u3059\uff0e<\/p>\n<p>\u3000\u306a\u305c\u30d5\u30c3\u5316\u7b2c\u4e00\u30b9\u30ba\u306f<em>S.mutans<\/em>\u306b\u5bfe\u3057\u52b9\u679c\u304c\u3042\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff0e<em>S. mutans\u306f\uff0c<\/em>\u30b9\u30ba\u30a4\u30aa\u30f3\u306b\u9ad8\u3044\u53d7\u5bb9\u529b\u3068\u89aa\u548c\u6027\u3092\u6709\u3059\u308b\u3053\u304c\u308f\u304b\u3063\u3066\u3044\u307e\u3059<sup>4-7)<\/sup>\uff0e\u3064\u307e\u308a<em>S.mutans<\/em>\u81ea\u4f53\u304c\u30b9\u30ba\u30a4\u30aa\u30f3\u3092\u53d6\u308a\u8fbc\u307f\u3084\u3059\u304f\uff0c\u6297\u83cc\u4f5c\u7528\u3092\u767a\u73fe\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\uff0e<\/p>\n<p>\u3000\u30d5\u30c3\u5316\u7b2c\u4e00\u30b9\u30ba\u306e\u4f7f\u7528\u306b\u3088\u3063\u3066\u6b6f\u5217\u77ef\u6b63\u4e2d\u306e\u30b7\u30d3\u30a2\u306a\u53e3\u8154\u74b0\u5883\u3067\u3082\uff0c\u3046\u8755\u306e\u767a\u751f\u304a\u3088\u3073\u9032\u884c\u3092\u6291\u5236\u3067\u304d\u305f<sup>8)<\/sup>\u3068\u3059\u308b\u5831\u544a\u3084\uff0c\u6b6f\u57a2\u30fb\u6b6f\u8089\u30fb\u51fa\u8840\u306e\u30b9\u30b3\u30a2\u304c\u6709\u610f\u306b\u4f4e\u304f\uff0c\u6b6f\u8089\u708e\u4e88\u9632\u306b\u306f0.4\uff05SnF<sub>2<\/sub>\u6b6f\u78e8\u5264\u306e\u4f7f\u7528\u304c\u6a5f\u68b0\u7684\u6b6f\u9762\u6e05\u6383\u306e\u88dc\u52a9\u3068\u3057\u3066\u6709\u52b9<sup>9)<\/sup>\uff0e\u3068\u3059\u308b\u5831\u544a\uff0c\u307e\u305f\uff0c0.12%\u306e\u30af\u30ed\u30eb\u30d8\u30ad\u30b7\u30b8\u30f3\u3068\u540c\u69d8\u306e\u6297\u83cc\u52b9\u679c\u3092\u793a\u3057\u305f<sup>10)<\/sup>\u3068\u3059\u308b\u5831\u544a\u304c\u307f\u3089\u308c\uff0c\u53e3\u8154\u5185\u7d30\u83cc\u306b\u5bfe\u3059\u308b\u512a\u308c\u305f\u52b9\u679c\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff0e<\/p>\n<p>\u3000\u30d5\u30c3\u5316\u7b2c\u4e00\u30b9\u30ba\u306f<em>S.mutans<\/em>\u3078\u306e\u52b9\u679c\u3060\u3051\u3067\u306f\u306a\u304f\uff0c\u8010\u9178\u6027\u306e\u9ad8\u3044\u9178\u5316\u30b9\u30ba\u3084\u30d5\u30c3\u5316\u30b9\u30ba\u3092\u5f62\u6210\u3057\u6b6f\u306e\u786c\u7d44\u7e54\u306e\u4fdd\u8b77\u306b\u5f79\u7acb\u3064\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059<sup>11,12)<\/sup>\uff0e\u786c\u7d44\u7e54\u306e\u8010\u9178\u6027\u3092\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u305f\u3081\uff0c\u77e5\u899a\u904e\u654f\u306b\u5bfe\u3057\u3082\u6709\u52b9\u6027\u304c\u9ad8\u3044\u3068\u3059\u308b\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc<sup>13,14)<\/sup>\u3082\u3042\u308a\u307e\u3059\uff0e<\/p>\n<p>&nbsp;<\/p>\n<h2>\uff12\uff0e\u30d5\u30c3\u5316\u7b2c\u4e00\u30b9\u30ba\u914d\u5408\u6b6f\u78e8\u5264\u4ee5\u5916(\u542b\u55fd\u3084\u5857\u5e03\u6cd5)\u306e\u30a8\u30d3\u30c7\u30f3\u30b9<\/h2>\n<p>\u3000\u6b6f\u78e8\u5264\u3067\u6b6f\u9762\u306b\u5fdc\u7528\u3055\u305b\u308b\u4ee5\u5916\u3067\u306f\u542b\u55fd\u3084\u30c7\u30f3\u30bf\u30eb\u30d5\u30ed\u30b9\u3092\u7528\u3044\u305f\u5857\u5e03\u6cd5\u306e\u5831\u544a\u304c\u3042\u308a\u307e\u3059\uff0e\u3044\u305a\u308c\u306b\u3057\u3066\u3082<em>S.mutans<\/em>\u306a\u3069\u3078\u306e\u52b9\u679c\u306b\u512a\u308c\u3066\u3044\u308b\u3068\u3044\u3046\u5831\u544a\u304c\u3088\u304f\u307f\u3089\u308c\u307e\u3057\u305f\uff0e<\/p>\n<p>\u3000\u542b\u55fd\u6cd5\u3067\u306f\uff0c<em>S. mutans<\/em>\u306e\u6570\u3092\u6709\u610f\u306b\u6e1b\u5c11\u3055\u305b\u305f<sup>15)<\/sup>\u3068\u3059\u308b\u5831\u544a\u3084\uff0c<em>S. mutans<\/em>\u3068<em>S. sanguis<\/em>\u306e\u4e21\u65b9\u304c\u6e1b\u5c11\u3057\u305f<sup>16)<\/sup>\uff0e\u3068\u3059\u308b\u5831\u544a\u304c\u3042\u308a\u307e\u3057\u305f\uff0e\u30c7\u30f3\u30bf\u30eb\u30d5\u30ed\u30b9\u3092\u7528\u3044\u305f\u5857\u5e03\u6cd5\u3067\u308210\uff05SnF<sub>2<\/sub>\u3067\u51e6\u7406\u3057\u305f\u3068\u3053\u308d<em>S. mutans<\/em>\u967d\u6027\u90e8\u4f4d\u306e\u6570\u304c\u6e1b\u5c11\u3057\u305f<sup>17)<\/sup>\uff0e\u3068\u3059\u308b\u5831\u544a\u304c\u3042\u308a\u307e\u3057\u305f\uff0e\u307e\u305f\uff0c\u30d2\u30c9\u30ed\u30ad\u30b7\u30a2\u30d1\u30bf\u30a4\u30c8\u3092\u7528\u3044\u305f\u57fa\u790e\u7814\u7a76\u3067\u306f\uff0cSnF<sub>2<\/sub>\u306fNaF\u3088\u308a\u3082\u8010\u9178\u6027\u304c\u6709\u610f\u306b\u5411\u4e0a\u3057\u305f<sup>18)<\/sup>\u3068\u3044\u3046\u5831\u544a\u3082\u3042\u308a\u307e\u3057\u305f\uff0e<\/p>\n<p>&nbsp;<\/p>\n<h2>\uff13\uff0e\u30d5\u30c3\u5316\u7b2c\u4e00\u30b9\u30ba\u6b6f\u78e8\u5264\u306e\u4f7f\u3044\u65b9<\/h2>\n<p><strong>(1)\u4ed6\u306e\u30d5\u30c3\u5316\u7269\u3068\u306e\u4f7f\u3044\u5206\u3051\u306b\u3064\u3044\u3066<\/strong><\/p>\n<p>\u3000\u30d5\u30c3\u5316\u7b2c\u4e00\u30b9\u30ba\u914d\u5408\u6b6f\u78e8\u5264\u306f\u3046\u8755\u30ea\u30b9\u30af\u691c\u67fb\u30d7\u30ed\u30b0\u30e9\u30e0\u3067\u3042\u308bCariogram\u7b49\u3067<em>S.mutans<\/em>\u306b\u3088\u308b\u30ea\u30b9\u30af\u56e0\u5b50\u304c\u9ad8\u3044\u3068\u5224\u65ad\u3057\u305f\u5834\u5408\u306b\u7a4d\u6975\u7684\u306b\u4f7f\u7528\u3057\u307e\u3059\u3002\u866b\u6b6f\u83cc(<em>S.mutans<\/em>)\u306e\u6570\u3092\u6e1b\u3089\u3059\u52b9\u679c\u304c\u9ad8\u3044\u306e\u306f\u30d5\u30c3\u5316\u7b2c\u4e00\u30b9\u30ba(SnF<sub>2<\/sub>)\u3067\u3059\u3068\u5358\u7d14\u306b\u8aac\u660e\u3057\u3066\u3088\u3044\u3068\u601d\u3044\u307e\u3059\uff0e\u4ed6\u306e\u30d5\u30c3\u5316\u7269\u3068\u540c\u69d8\u306b\u6b6f\u78e8\u5264\u3092\u4f5c\u7528\u3055\u305b\u305f\u5f8c\u306f\uff0c\u3046\u304c\u3044\u3084\u98f2\u98df\u7269\u3092\u63a7\u3048\u308b\u3068\u52b9\u679c\u304c\u9ad8\u3044\u3068\u8003\u3048\u3089\u308c\u307e\u3059\uff0e<\/p>\n<p><strong>(2)\u7740\u8272\u306b\u3064\u3044\u3066<\/strong><\/p>\n<p>\u3000\u30d5\u30c3\u5316\u7b2c\u4e00\u30b9\u30ba\u542b\u6709\u6b6f\u78e8\u5264\u306f\u3001\u9577\u671f\u7684\u306a\u4f7f\u7528\u306b\u3088\u3063\u3066\u6b6f\u306e\u8868\u9762\u306b\u7740\u8272\u304c\u8d77\u3053\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u307e\u3059<sup>19)<\/sup>\uff0e\u30d5\u30c3\u5316\u7b2c\u4e00\u30b9\u30ba\u3092\u6eb6\u6db2\u3068\u3057\u3066\u4f7f\u7528\u3057\u305f\u5834\u5408\uff0cpH2.8\u4ed8\u8fd1\u3068\u5f37\u3044\u9178\u6027\u3092\u6709\u3057\u3066\u304a\u308a\uff0c\u3053\u306e\u5f37\u3044\u9178\u6027\u5ea6\u306b\u3088\u3063\u3066\u30da\u30ea\u30af\u30eb\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u5909\u6027\u3057\uff0c\u30b9\u30ba\u30a4\u30aa\u30f3\u3068\u53cd\u5fdc\u3057\u786b\u5316\u30b9\u30ba\u304c\u7523\u751f\u3055\u308c\u305f\u7d50\u679c\u3068\u306e\u5831\u544a<sup>20)<\/sup>\u304c\u3042\u308a\u307e\u3059\uff0e\u3057\u304b\u3057\uff0c\u6b6f\u78e8\u5264\u3068\u3057\u3066\u5e02\u8ca9\u3055\u308c\u3066\u3044\u308b\u88fd\u54c1\u306e\u5834\u5408\uff0cpH\u304c\u4e2d\u6027\u306b\u8abf\u6574\u3055\u308c\u3066\u3044\u308b\uff08FEED\u304c\u8ca9\u58f2\u3057\u3066\u3044\u308b\u30d4\u30c9\u30b1\u30a2\u306e\u5834\u5408\uff0cpH\u306f6.8\u00b10.3\u306b\u8abf\u6574\u3055\u308c\u3066\u3044\u307e\u3059<sup>21)<\/sup>\uff09\uff0e\u3053\u3068\u304c\u591a\u304f\uff0c\u6b6f\u78e8\u5264\u3067\u3082\u7740\u8272\u304c\u8d77\u3053\u308b\u7406\u7531\u3068\u3057\u3066\u305d\u306e\u307e\u307e\u53d7\u3051\u5165\u308c\u308b\u3053\u3068\u306f\u56f0\u96e3\u3067\u3059\uff0e<\/p>\n<p>\u3000\u4e00\u65b9\uff0c\u30d5\u30c3\u5316\u7b2c\u4e00\u30b9\u30ba\u914d\u5408\u6b6f\u78e8\u5264\u300c\u30db\u30fc\u30e0\u30b8\u30a7\u30eb\u300d\u3092\u8ca9\u58f2\u3059\u308b\u30aa\u30fc\u30e9\u30eb\u30b1\u30a2\u793e\u306eWeb\u30da\u30fc\u30b8\u3067\u306f\uff0c\u30d7\u30e9\u30fc\u30af\u3084\u3060\u6db2\u306b\u542b\u307e\u308c\u3066\u3044\u308b\u786b\u9ec4\u3068\u30b9\u30ba\u30a4\u30aa\u30f3\u304c\u53cd\u5fdc\u3057\u3066\u6b6f\u9762\u306b\u6c88\u7740\u3059\u308b<sup>22)<\/sup>\u3068\u8aac\u660e\u3055\u308c\u3066\u3044\u307e\u3059\uff0e\u78ba\u304b\u306b\u53e3\u8154\u5185\u306e\u30d7\u30e9\u30fc\u30af\u306b\u5b58\u5728\u3059\u308b<em>P.gingivalis<\/em>\u306f\u63ee\u767a\u6027\u786b\u9ec4\u5316\u5408\u7269\u3092\u7523\u751f\u3059\u308b<sup>23)<\/sup>\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u307e\u3059\u3057\uff0c<em>Treponema denticola<\/em>\u3082\u786b\u5316\u7269\u3092\u751f\u6210\u3057\u307e\u3059<sup>24)<\/sup>\uff0e\u3053\u308c\u3089\u306e\u7d30\u83cc\u304c\u30b9\u30ba\u30a4\u30aa\u30f3\u3068\u53cd\u5fdc\u3057\u7740\u8272\u306e\u539f\u56e0\u7269\u8cea\u3067\u3042\u308b\u786b\u5316\u30b9\u30ba\u3092\u4f5c\u308a\u51fa\u3059\u3068\u3044\u3046\u8aac\u660e\u3067\u3059\uff0e\u3064\u307e\u308a\uff0c\u4f7f\u7528\u65b9\u6cd5\u3068\u3057\u3066\u6b6f\u78e8\u5264\u3068\u540c\u69d8\u306b\u3044\u304d\u306a\u308a\u53e3\u8154\u5185\u306b\u5165\u308c\u308b\u306e\u3067\u306f\u306a\u304f\uff0c\u6b6f\u78e8\u5264\u3067\u30d7\u30e9\u30fc\u30af\u3092\u843d\u3068\u3057\u3066\u304b\u3089\u30d5\u30c3\u5316\u7b2c\u4e00\u30b9\u30ba\u6b6f\u78e8\u5264\u3092\u4f5c\u7528\u3055\u305b\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u7740\u8272\u3092\u4e88\u9632\u3057\u307e\u3057\u3087\u3046\u306d\uff0e\u3068\u3044\u3046\u3053\u3068\u3067\u3059\uff0e\u30d5\u30c3\u5316\u7b2c\u4e00\u30b9\u30ba\u306b\u3088\u308b\u7740\u8272\u306f\u30dd\u30ea\u30c3\u30b7\u30f3\u30b0\u306a\u3069\u3067\u7c21\u5358\u306b\u9664\u53bb\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u306e\u3067\uff0c\u305d\u3093\u306a\u306b\u6c17\u306b\u3057\u306a\u304f\u3066\u3082\u3088\u3044\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\uff0e<\/p>\n<p><strong>(3)\u5473\u30fb\u9999\u308a\u306b\u3064\u3044\u3066<\/strong><\/p>\n<p>\u3000\u30d5\u30c3\u5316\u7b2c\u4e00\u30b9\u30ba\u914d\u5408\u6b6f\u78e8\u5264\u306f\uff0c\u7279\u6709\u306e\u82e6\u307f\u3084\u91d1\u5c5e\u306e\u3088\u3046\u306a\u5473\u3092\u611f\u3058\u307e\u3059\u304c\uff0c\u4f7f\u7528\u3092\u7d9a\u3051\u308b\u3053\u3068\u3067\u6163\u308c\u308b\u3053\u3068\u304c\u51fa\u6765\u307e\u3059\uff0e\u307e\u305f\uff0c\u88fd\u54c1\u306b\u3088\u3063\u3066\u69d8\u3005\u306a\u9999\u5473\u304c\u4ed8\u3051\u3089\u308c\u3066\u3044\u307e\u3059\u306e\u3067\uff0c\u60a3\u8005\u306e\u597d\u307f\u306b\u5408\u3046\u3082\u306e\u3092\u9078\u629e\u3055\u305b\u4f7f\u7528\u3092\u7d99\u7d9a\u3057\u307e\u3059\uff0e<\/p>\n<p><strong>(4)\u91d1\u5c5e\u30a2\u30ec\u30eb\u30ae\u30fc\u306b\u3064\u3044\u3066<\/strong><\/p>\n<p>\u3000\u30d5\u30c3\u5316\u7b2c\u4e00\u30b9\u30ba\u914d\u5408\u6b6f\u78e8\u5264\u306b\u306f\u91d1\u5c5e\u30a4\u30aa\u30f3\u3067\u3042\u308b\u30b9\u30ba\u30a4\u30aa\u30f3\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3059\uff0e\u91d1\u5c5e\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u5831\u544a\u306b\u3064\u3044\u3066\u306f\u898b\u3064\u3051\u308b\u3053\u3068\u304c\u51fa\u6765\u307e\u305b\u3093\u3067\u3057\u305f\u304c\uff0c\u5b9f\u969b\u306e\u4f7f\u7528\u306b\u3064\u3044\u3066\u306f\u4f7f\u7528\u958b\u59cb\u524d\u306b\u554f\u8a3a\u3067\u78ba\u8a8d\u3057\u305f\u307b\u3046\u304c\u3088\u3055\u305d\u3046\u3067\u3059\uff0e<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<h2>\uff14\uff0e\u307e\u3068\u3081\u30fb\u72ec\u308a\u8a00<\/h2>\n<p>\u3000\u4eca\u56de\u306f\u30d5\u30c3\u5316\u7269\u306e\u4e2d\u3067\u3082\u30de\u30a4\u30ca\u30fc\u306a\u30d5\u30c3\u5316\u7b2c\u4e00\u30b9\u30ba\u3092\u53d6\u308a\u4e0a\u3052\u3066\u307f\u307e\u3057\u305f\uff0e\u4eca\u307e\u3067\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u306a\u3093\u3068\u306a\u304f\u3075\u308f\u3063\u3068\u3054\u7d39\u4ecb\u3057\u305f\u3060\u3051\u306b\u306a\u3063\u3066\u3057\u307e\u3044\u307e\u3057\u305f\uff0e\u6b6f\u5468\u6cbb\u7642\u5206\u91ce\u3067\u3082\u5316\u5b66\u7684\u30d7\u30e9\u30fc\u30af\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u5264\u3068\u3057\u3066\u7528\u3044\u3089\u308c\u3066\u3044\u307e\u3059\u304c\uff0c\u4eca\u56de\u306f\u3046\u8755\u4e88\u9632\u52b9\u679c\u306e\u307f\u53d6\u308a\u4e0a\u3052\u3066\u3044\u307e\u3059\uff0e<\/p>\n<p>(1) \u30b9\u30ba\u306f\u539f\u5b50\u756a\u53f750\uff0c\u7d00\u5143\u524d\u306e\u53e4\u304f\u304b\u3089\u88c5\u98fe\u54c1\u3068\u3057\u3066\u7528\u3044\u3089\u308c\u3066\u304d\u305f\uff0e\u88fd\u54c1\u3068\u3057\u3066\u306f\u30cf\u30f3\u30c0\u3084\u30d6\u30ea\u30ad\u306e\u304a\u3082\u3061\u3083\u304c\u300c\u30b9\u30ba\u300d\u3067\u4f5c\u3089\u308c\u3066\u3044\u307e\u3059\uff0e<\/p>\n<p>(2) \u57fa\u790e\u30fb\u81e8\u5e8a\u554f\u308f\u305a\u591a\u304f\u306e\u6587\u732e\u304c\u307f\u3089\u308c\u305f\u3082\u306e\u306e\uff0c\u4ed6\u306e\u30d5\u30c3\u5316\u7269\u3068\u6bd4\u8f03\u3057\u3066\u30d5\u30c3\u5316\u7b2c\u4e00\u30b9\u30ba\u6b6f\u78e8\u5264\u306e\u5831\u544a\u306f\u5c11\u306a\u304b\u3063\u305f\uff0e<\/p>\n<p>(3) \u57f9\u990a\u3084Cariogram\u7b49\u3067<em>S.mutans<\/em>\u304c\u591a\u3044\u3068\u5224\u65ad\u3057\u305f\u5834\u5408\u306b\u304a\u3059\u3059\u3081\uff0e<\/p>\n<p>(4) \u91d1\u5c5e\u30a2\u30ec\u30eb\u30ae\u30fc\u3092\u542b\u3081\uff0c\u9577\u671f\u4f7f\u7528\u306b\u3088\u308b\u7740\u8272\u4ee5\u5916\u306e\u526f\u4f5c\u7528\u5831\u544a\u4ee5\u5916\u306f\u898b\u3064\u3051\u308b\u3053\u3068\u304c\u51fa\u6765\u307e\u305b\u3093\u3067\u3057\u305f\uff0e<\/p>\n<p>(5) SnF<sub>2<\/sub>\u306f\u5b89\u5b9a\u6027\u306b\u4e4f\u3057\u3044\u305f\u3081\uff0c\u767a\u6ce1\u5264\u3084\u7814\u78e8\u5264\u304c\u672a\u914d\u5408\u3067\u3042\u308b\u3053\u3068\u304c\u591a\u3044\uff0e\u3060\u304b\u3089\u7740\u8272\u3082\u8d77\u3053\u308a\u3084\u3059\u3044\u3068\uff0e<\/p>\n<p>(6) \u7d30\u83cc\u3092\u6e1b\u3089\u3059\u3060\u3051\u3067\u306f\u306a\u304f\uff0c\u6b6f\u306e\u8010\u9178\u6027\u3082\u5411\u4e0a\u3055\u305b\u77e5\u899a\u904e\u654f\u306b\u3082\u6709\u52b9\u6027\u304c\u9ad8\u3044\uff0e<\/p>\n<p>&nbsp;<\/p>\n<h2>\uff15\uff0eColgate Gel-Kam<sup>\u00ae<\/sup>\u3092\u8cfc\u5165\u3057\u3066\u307f\u305f<\/h2>\n<p><img data-recalc-dims=\"1\" decoding=\"async\" class=\"aligncenter size-large wp-image-1178\" src=\"https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2021\/09\/Gel-Kam.jpg?resize=665%2C444\" alt=\"\" width=\"665\" height=\"444\" srcset=\"https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2021\/09\/Gel-Kam.jpg?resize=1024%2C683&amp;ssl=1 1024w, https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2021\/09\/Gel-Kam.jpg?resize=300%2C200&amp;ssl=1 300w, https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2021\/09\/Gel-Kam.jpg?resize=768%2C512&amp;ssl=1 768w, https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2021\/09\/Gel-Kam.jpg?resize=1536%2C1024&amp;ssl=1 1536w, https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2021\/09\/Gel-Kam.jpg?resize=660%2C440&amp;ssl=1 660w, https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2021\/09\/Gel-Kam.jpg?w=1920&amp;ssl=1 1920w, https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2021\/09\/Gel-Kam.jpg?w=1330 1330w\" sizes=\"(max-width: 665px) 100vw, 665px\" \/><\/p>\n<p>Amazon.com\u3067\u8cfc\u5165\u3057\u3066\u307f\u307e\u3057\u305f\uff0e\u7c73\u56fd\u3067\u306f\u666e\u901a\u306b\u8ca9\u58f2\u3055\u308c\u3066\u3044\u307e\u3059\uff0e<br \/>\n$11.49\u3060\u3063\u305f\u306e\u3067\u5927\u4f531,300\u5186($1=113.51\u518610\/14\u73fe\u5728)\u3067\u3057\u305f\uff0e\u6b32\u3057\u3044\u65b9\u7528\u306bAmazon.com\u306e<a href=\"https:\/\/www.amazon.com\/Gel-Kam-Fluoride-Preventive-Treatment-Flavor\/dp\/B0013TXFFY\/ref=sr_1_3?dchild=1&amp;keywords=gel+kam&amp;qid=1634195506&amp;sr=8-3\">\u30ea\u30f3\u30af<\/a>\u3092\u8cbc\u3063\u3066\u304a\u304d\u307e\u3059\uff0e<br \/>\n0.4%Stannous fluoride\u306a\u306e\u3067950ppm\u3068\u304b\uff0c960ppm\u3068\u304b\uff0e\u5473\u306fFRUIT&amp;BERRY\uff01\u3068\u3044\u3046\uff0c\u3044\u304b\u306b\u3082\u7c73\u56fd\u306e\u6b6f\u78e8\u5264\u3067\u3059\uff0e<br \/>\n\u3061\u306a\u307f\u306b\u4eca\u307c\u304f\u304c\u4f7f\u3063\u3066\u3044\u308b\u6b6f\u78e8\u304d\u7c893M Clinpro5000\u3082Bubble Gum\u5473\u3067\u3059\uff0e<\/p>\n<p>Drug Facts\u306b\u306f\u4f55\u304c\u66f8\u3044\u3066\u3042\u308b\u304b\u3068\u3044\u3046\u3068\u30fb\u30fb\u30fb<br \/>\n\u30fbadults and children 12years of age or older: use after regular brushing and flossing<br \/>\n\u3000\u5927\u4eba\u306812\u6b73\u4ee5\u4e0a\u306e\u5b50\u4f9b\u306b\u4f7f\u7528\u3057\u3066\u304f\u3060\u3055\u3044\uff0e\u901a\u5e38\u306e\u6b6f\u78e8\u304d\u3068\u30d5\u30ed\u30b9\u306e\u5f8c\u306b\u4f7f\u7528\u3057\u3066\u304f\u3060\u3055\u3044\uff0e<br \/>\n\u30fbshake excess water from your toothbrush and cover bristles with gel<br \/>\n\u3000\u6b6f\u30d6\u30e9\u30b7\u306b\u3064\u3044\u305f\u6c34\u3092\u3088\u304f\u5207\u3063\u3066\uff0c\u30b8\u30a7\u30eb\u3092\u6b6f\u30d6\u30e9\u30b7\u306b\u3064\u3051\u307e\u3059\uff0e<br \/>\n\u30fbbrush thoroughly<br \/>\n\u3000\u5341\u5206\u306b\u6b6f\u3092\u78e8\u3044\u3066\u304f\u3060\u3055\u3044\uff0e<br \/>\n\u30fbkeep on your teeth for one minute and then spit out<br \/>\n\u3000\uff11\u5206\u9593\u78e8\u3044\u305f\u5f8c\uff0c\u5410\u304d\u51fa\u3057\u3066\u304f\u3060\u3055\u3044\uff0e<br \/>\n\u30fbdo not swallow<br \/>\n\u3000\u98f2\u307f\u8fbc\u307e\u306a\u3044\u3067\u304f\u3060\u3055\u3044\uff0e<br \/>\n\u30fbdo not rinse, eat or drink for 30 minutes<br \/>\n\u300030\u5206\u306f\u3086\u3059\u3044\u3060\u308a\uff0c\u98f2\u98df\u3092\u907f\u3051\u3066\u304f\u3060\u3055\u3044\uff0e<br \/>\n\u30fbuse once a day for cavity protection<br \/>\n\u3000\u3046\u8755\u4e88\u9632\u306e\u305f\u3081\u306b\uff11\u65e5\uff11\u56de\u4f7f\u7528\u3057\u3066\u304f\u3060\u3055\u3044\uff0e<br \/>\n\u30fbuse twice a day (morning and evening) for sensitivity relief or as recommended by a dentist or physician<br \/>\n\u3000\u533b\u5e2b\u3084\u6b6f\u79d1\u533b\u5e2b\u306b\u52e7\u3081\u3089\u308c\u305f\u6642\u3084\u77e5\u899a\u904e\u654f\u4e88\u9632\u306e\u305f\u3081\u306b\u306f\uff11\u65e5\uff12\u56de(\u671d\u30fb\u5915)\u4f7f\u7528\u3057\u3066\u304f\u3060\u3055\u3044\uff0e<br \/>\n\u30fbmake sure all sensitive areas are covered by using a toothbrush or a cotton swab<br \/>\n\u3000\u77e5\u899a\u904e\u654f\u306e\u90e8\u4f4d\u306b\u306f\u6b6f\u30d6\u30e9\u30b7\u3084\u7dbf\u68d2\u3092\u4f7f\u3063\u3066\u3057\u3063\u304b\u308a\u3068\u8986\u3063\u3066\u304f\u3060\u3055\u3044\uff0e<br \/>\n\u30fbsupervise children until capable of using without supervision<br \/>\n\u3000\u5c0f\u5150\u304c\u4f7f\u7528\u3059\u308b\u5834\u5408\u306f\u6b63\u3057\u304f\u4f7f\u3048\u308b\u3088\u3046\u306b\u306a\u308b\u307e\u3067\u76e3\u7763\u3057\u3066\u304f\u3060\u3055\u3044\uff0e<br \/>\n\u30fbchildren under 12 years of age: consult a dentist or physician<br \/>\n\u300012\u6b73\u672a\u6e80\u306e\u5c0f\u5150\u306f\uff0c\u6b6f\u79d1\u533b\u5e2b\u307e\u305f\u306f\u533b\u5e2b\u306b\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\uff0e<\/p>\n<p>\u3068\u66f8\u3044\u3066\u3042\u308a\u307e\u3059\uff0e<br \/>\n\u6b6f\u78e8\u304d\u3068\u30d5\u30ed\u30b9\u306e\u5f8c\u306b\u4f7f\u7528\u3057\u3066\u304f\u3060\u3055\u3044\u3068\u3061\u3083\u3093\u3068\u66f8\u3044\u3066\u3042\u308a\u307e\u3059\uff0e<br \/>\n\u305d\u3057\u3066\uff0c\u77e5\u899a\u904e\u654f\u3078\u306e\u52b9\u80fd\u3092\u3061\u3083\u3093\u3068\u3046\u305f\u3063\u3066\u3044\u307e\u3059\u306d\uff0e<\/p>\n<p>&nbsp;<\/p>\n<h2>\uff16\uff0e\u30d5\u30c3\u5316\u7b2c\u4e00\u30b9\u30ba\u306e\u4eca\u5f8c\u3000\uff5e\u30af\u30ea\u30a2\u3059\u3079\u304d\u8ab2\u984c\uff5e<\/h2>\n<p><strong>(1)\u30d5\u30c3\u7d20\u6fc3\u5ea6\u3068\u5bfe\u8c61\u5e74\u9f62<\/strong><\/p>\n<p>\u30002017\u5e74\uff0c\u539a\u751f\u52b4\u50cd\u7701\u306b\u3088\u3063\u3066\u30d5\u30c3\u7d20\u30a4\u30aa\u30f3\u6fc3\u5ea6\u6539\u5b9a\u304c\u3055\u308c\u307e\u3057\u305f\u304c\uff0c\u30d5\u30c3\u5316\u7b2c\u4e00\u30b9\u30ba\u306f\u6fc3\u5ea6\u4e0a\u9650\u304c1,000ppm\u306e\u307e\u307e\u636e\u3048\u7f6e\u304b\u308c\u307e\u3057\u305f(\u304a\u305d\u3089\u304f1,500ppm\u306b\u3057\u305f\u5834\u5408\u306e\u30c7\u30fc\u30bf\u304c\u5c11\u306a\u3044\u304b\u3089)\uff0e\u73fe\u5728\uff0c\u4ed6\u306e\u30d5\u30c3\u5316\u7269\u914d\u5408\u6b6f\u78e8\u5264\u306f1.500ppm(1,450ppm\u7a0b\u5ea6)\u306e\u30d5\u30c3\u7d20\u30a4\u30aa\u30f3\u6fc3\u5ea6\u3092\u6301\u3064\u6b6f\u78e8\u5264\u304c\u8ca9\u58f2\u3055\u308c\u3066\u3044\u308b\u306e\u3067\u6210\u4eba\u306e\u65b9\u306e\u5834\u5408\uff0c\u4e00\u898b\uff0c\u898b\u52a3\u308a\u3057\u3066\u3057\u307e\u3046\u306e\u306f\u5426\u3081\u306a\u3044\u3068\u601d\u3044\u307e\u3059\uff0e\u73fe\u5728\uff0c\u5e02\u8ca9\u3055\u308c\u3066\u3044\u308b\u30d5\u30c3\u5316\u7b2c\u4e00\u30b9\u30ba\u88fd\u5264\u306f1,000ppm(950ppm\u7a0b\u5ea6)\u306a\u306e\u3067\uff0c\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u4e0a\uff0c14\u6b73\u4ee5\u4e0b\u306b\u3082\u4f7f\u7528\u3067\u304d\u307e\u3059\uff0e<\/p>\n<p><strong>(2)\u6b6f\u79d1\u533b\u7642\u5f93\u4e8b\u8005\u306e\u7406\u89e3\u3068\u30de\u30fc\u30b1\u30c3\u30c8<\/strong><\/p>\n<p>\u3000\u4eca\u56de\uff0c\u30d5\u30c3\u5316\u7b2c\u4e00\u30b9\u30ba\u88fd\u5264\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u7d39\u4ecb\u3057\u3066\u3044\u304d\u307e\u3057\u305f\uff0e\u65e5\u672c\u306e\u6b6f\u79d1\u533b\u5e2b\u30fb\u6b6f\u79d1\u885b\u751f\u58eb\u304c\u4f7f\u7528\u3059\u308b\u6559\u79d1\u66f8\u306b\u306f\uff0c\u3055\u3089\u3063\u3068\u3057\u304b\u7d39\u4ecb\u3055\u308c\u3066\u304a\u3089\u305a\uff0c\u65e5\u672c\u3067\u306f\u6b6f\u79d1\u533b\u7642\u5f93\u4e8b\u8005\u3067\u3059\u3089\u5145\u5206\u306b\u7406\u89e3\u3055\u308c\u3066\u3044\u306a\u3044\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u611f\u3058\u307e\u3057\u305f\uff0e\u4e00\u822c\u7684\u306b\u30c9\u30e9\u30c3\u30b0\u30b9\u30c8\u30a2\u3067\u8ca9\u58f2\u3055\u308c\u3066\u3044\u306a\u3044\u30d5\u30c3\u5316\u7b2c\u4e00\u30b9\u30ba\u88fd\u5264\u3067\u3059\u306e\u3067\uff0c\u6b6f\u79d1\u533b\u5e2b\u30fb\u6b6f\u79d1\u885b\u751f\u58eb\u304b\u3089\u9069\u5207\u306b\u60c5\u5831\u63d0\u4f9b\u3055\u308c\u306a\u3044\u9650\u308a\u30d5\u30c3\u5316\u7b2c\u4e00\u30b9\u30ba\u306e\u7406\u89e3\u304c\u5e83\u307e\u308b\u3053\u3068\u306f\u3042\u308a\u307e\u305b\u3093\uff0e\u6b6f\u79d1\u533b\u7642\u5f93\u4e8b\u8005\u3060\u3051\u3067\u306f\u306a\u304f\u4ed6\u306e\u533b\u7642\u5f93\u4e8b\u8005\u306b\u3082\u30d5\u30c3\u5316\u7b2c\u4e00\u30b9\u30ba\u3078\u306e\u7406\u89e3\u3092\u6df1\u3081\u3066\u3082\u3089\u3044\uff0c\u4e00\u822c\u6d88\u8cbb\u8005\u306b\u5e83\u304c\u308b\u3068\u3044\u3044\u306a\u3068\u8003\u3048\u307e\u3057\u305f\uff0e<\/p>\n<p><strong>(3)\u91d1\u5c5e\u5473<\/strong><\/p>\n<p>\u3000\u73fe\u5728\uff0c\u8ca9\u58f2\u3055\u308c\u3066\u3044\u308b\u30d5\u30c3\u5316\u7b2c\u4e00\u30b9\u30ba\u914d\u5408\u6b6f\u78e8\u5264\u306b\u306f\u30d5\u30eb\u30fc\u30c4\u5473\u3084\u30e9\u30e0\u30cd\u5473\u306a\u3069\uff0c\u3067\u304d\u308b\u3060\u3051\u30d5\u30c3\u5316\u7b2c\u4e00\u30b9\u30ba\u7279\u6709\u306e\u91d1\u5c5e\u5473\u3092\u30de\u30b9\u30af\u3059\u308b\u3088\u3046\u306a\u9999\u5473\u304c\u4ed8\u3051\u3089\u308c\u3066\u3044\u307e\u3059\uff0e\u305d\u308c\u3067\u3082\u53e3\u306b\u542b\u307f\u30d6\u30e9\u30c3\u30b7\u30f3\u30b0\u3067\u4f7f\u7528\u3057\u3066\u3044\u308b\u3068\u91d1\u5c5e\u5473\u304c\u51fa\u3066\u3057\u307e\u3044\u307e\u3059\uff0e\u611f\u3058\u65b9\u306f\u4eba\u305d\u308c\u305e\u308c\u3067\u3059\u304c\uff0c\u300c\u30a4\u30e4\u3060\u300d\u3068\u8a00\u308f\u308c\u3066\u3057\u307e\u3046\u4e00\u3064\u306e\u8981\u56e0\u3067\u3059\uff0e\u4e00\u3064\u306e\u3053\u306e\u8fba\u304c\u30af\u30ea\u30a2\u3067\u304d\u308c\u3070\u3082\u3063\u3068\u4f7f\u3063\u3066\u304f\u308c\u308b\u4eba\u304c\u5897\u3048\u3066\u3044\u304f\u306e\u3067\u306f\u306a\u3044\u304b\u306a\u3068\u8003\u3048\u307e\u3059\uff0e\u91d1\u5c5e\u5473\u3092\u5c11\u306a\u304f\u3059\u308b\u5de5\u592b\u3068\u3057\u3066\u306f\uff0c\u30d5\u30c3\u5316\u7b2c\u4e00\u30b9\u30ba\u914d\u5408\u6b6f\u78e8\u5264\u306e\u524d\u306b\uff0c\u4ed6\u306e\u30d5\u30c3\u5316\u7269\u914d\u5408\u6b6f\u78e8\u5264\u3067\u30d6\u30e9\u30c3\u30b7\u30f3\u30b0\u3092\u3057\u3066\u304b\u3089\u4f7f\u3044\u307e\u3059\uff0e<\/p>\n<p><strong>(4)\u7740\u8272<\/strong><\/p>\n<p>\u3000\u672c\u6587\u3067\u3082\u3054\u7d39\u4ecb\u3057\u305f\u3088\u3046\u306b\u30d5\u30c3\u5316\u7b2c\u4e00\u30b9\u30ba\u88fd\u5264\u306f\u7740\u8272\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\uff0e\u5916\u56e0\u6027\u306e\u7740\u8272\u306a\u306e\u3067\u7814\u78e8\u5264\u304c\u914d\u5408\u3055\u308c\u3066\u3044\u308c\u3070\u3042\u308b\u7a0b\u5ea6\u7740\u8272\u304c\u9632\u6b62\u3055\u308c\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u3082\u601d\u3044\u307e\u3059\u304c\uff0c\u30d5\u30c3\u5316\u7b2c\u4e00\u30b9\u30ba\u88fd\u5264\u306f\u7814\u78e8\u5264\u3068\u306e\u517c\u306d\u5408\u3044\u304c\u56f0\u96e3\u306a\u3088\u3046\u3067\u3059\uff0e\u540c\u69d8\u306e\u7406\u7531\u3067\u767a\u6ce1\u5264\u3082\u542b\u307e\u308c\u3066\u3044\u307e\u305b\u3093\u304c\uff0c\u3053\u3061\u3089\u3082\u597d\u307f\u304c\u5206\u304b\u308c\u307e\u3059\u306d\uff0e<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<h2>\uff17\uff0e\u53c2\u8003\u6587\u732e<\/h2>\n<p>\u30d5\u30c3\u5316\u7b2c\u4e00\u30b9\u30ba(SnF<sub>2<sup>)<\/sup><\/sub>\u306e\u6587\u732e\u306f\u53e4\u3044\u3082\u306e\u3082\u591a\u304f\uff0c\u533b\u5b66\u90e8\u56f3\u66f8\u9928\u306b\u3082\u306a\u304b\u3063\u305f\u8ad6\u6587\u306fabstract\u304b\u3089\u5f15\u7528\u3057\u305f\u6587\u732e\u3082\u3042\u308a\u307e\u3059\uff0e<\/p>\n<p>1)\u00a0 Muhler JC, Van Huysen G. Solubility of enamel protected by sodium fluoride and other compounds. J Dent Res. 1947 Apr;26(2):119-27.<\/p>\n<p>2) \u65e5\u672c\u53e3\u8154\u885b\u751f\u5b66\u4f1a \u30d5\u30c3\u5316\u7269\u5fdc\u7528\u59d4\u54e1\u4f1a\u7de8(2017)\u3000\u3046\u8755\u4e88\u9632\u306e\u5b9f\u969b\u30d5\u30c3\u5316\u7269\u5c40\u6240\u5fdc\u7528\u5b9f\u65bd\u30de\u30cb\u30e5\u30a2\u30eb \u793e\u4f1a\u4fdd\u967a\u7814\u7a76\u6240<\/p>\n<p>3) Kirthiga M, Murugan M, Saikia A, Kirubakaran R. Risk Factors for Early Childhood Caries: A Systematic Review and Meta-Analysis of Case Control and Cohort Studies. Pediatr Dent. 2019 Mar 15;41(2):95-112.<\/p>\n<p>4) Attramadal A, Svatun B. Uptake and retention of tin by S. mutans. Acta Odontol Scand. 1980;38(6):349-54.<\/p>\n<p>5) Keene HJ, Shklair IL, Hoerman KC. Partial elimination of Streptococcus mutans from selected tooth surfaces after restoration of carious lesions and SnF2 prophylaxis. J Am Dent Assoc. 1976 Aug;93(2):328-33.<\/p>\n<p>6) \u5409\u6cbc \u76f4\u4eba, \u97f3\u7434 \u6df3\u4e00\u3089 (1995)\u30000.4%\u30d5\u30c3\u5316\u7b2c\u4e00\u30b9\u30ba\u542b\u6709\u30da\u30fc\u30b9\u30c8\u304c\u81e8\u5e8a\u75c7\u72b6\u304a\u3088\u3073\u553e\u6db2\u4e2d\u306eStreptococcus mutans\u6570\u306b\u304a\u3088\u307c\u3059\u52b9\u679c\u306b\u3064\u3044\u3066 \u6b6f\u85ac\u7642\u6cd514-2 P119-124<\/p>\n<p>7) Tseng CC, Wolff LF, Aeppli DM. Effect of gels containing stannous fluoride on oral bacteria&#8211;an in vitro study. Aust Dent J. 1992 Oct;37(5):368-73.<\/p>\n<p>8) Stratemann MW, Shannon IL. Control of decalcification in orthodontic patients by daily self-administered application of a water-free 0.4 per cent stannous fluoride gel. Am J Orthod. 1974 Sep;66(3):273-9.<\/p>\n<p>9) Boyd RL, Chun YS. Eighteen-month evaluation of the effects of a 0.4% stannous fluoride gel on gingivitis in orthodontic patients. Am J Orthod Dentofacial Orthop. 1994 Jan;105(1):35-41.<\/p>\n<p>10) Tseng CC, Wolff LF, Aeppli DM. Effect of gels containing stannous fluoride on oral bacteria&#8211;an in vitro study. Aust Dent J. 1992 Oct;37(5):368-73.<\/p>\n<p>11) Berndt AF. Reaction of stannous fluoride with hydroxyapatite: the crystal structure of Sn 3 PO 4 F 3 . J Dent Res. 1972 Jan-Feb;51(1):53-7.<\/p>\n<p>12) Feller RP. Reduction of enamel solubility by daily use of a 0.4 per cent stannous fluoride gel. J Dent Res. 1974 Sep-Oct;53(5):1280-3.\u00a0<\/p>\n<p>13)\u00a0 Konradsson K, Lingstr\u00f6m P, Emilson CG, Johannsen G, Ramberg P, Johannsen A. Stabilized stannous fluoride dentifrice in relation to dental caries, dental erosion and dentin hypersensitivity: A systematic review. Am J Dent. 2020 Apr;33(2):95-105.\u00a0<\/p>\n<p>14) West NX, He T, Zou Y, DiGennaro J, Biesbrock A, Davies M. Bioavailable gluconate chelated stannous fluoride toothpaste meta-analyses: Effects on dentine hypersensitivity and enamel erosion. J Dent. 2021 Feb;105:103566.<\/p>\n<p>15) Svanberg M, R\u00f6lla G. Streptococcus mutans in plaque and saliva after mouthrinsing with SnF2. Scand J Dent Res. 1982 Aug;90(4):292-8.<\/p>\n<p>16) Svanberg M, Westergren G. Effect of SnF2, administered as mouthrinses or topically applied, on Streptococcus mutans, Streptococcus sanguis and lactobacilli in dental plaque and saliva. Scand J Dent Res. 1983 Apr;91(2):123-9.<\/p>\n<p>17) Keene HJ, Shklair IL, Mickel GJ. Effect of multiple dental floss-SnF2 treatment on Streptococcus mutans in interproximal plaque. J Dent Res. 1977 Jan;56(1):21-7.<\/p>\n<p>18) Baig AA, Faller RV, Yan J, Ji N, Lawless M, Eversole SL. Protective effects of SnF2 &#8211; Part I. Mineral solubilisation studies on powdered apatite. Int Dent J. 2014 Mar;64 Suppl 1:4-10.<\/p>\n<p>19) Boyd RL, Chun YS. Eighteen-month evaluation of the effects of a 0.4% stannous fluoride gel on gingivitis in orthodontic patients. Am J Orthod Dentofacial Orthop. 1994 Jan;105(1):35-41.<\/p>\n<p>20) Ellingsen JE, Eriksen HM, R\u00f6lla G. Extrinsic dental stain caused by stannous fluoride. Scand J Dent Res. 1982 Feb;90(1):9-13.<\/p>\n<p>21) \u6728\u6751 \u82f1\u4e00\u90ce, \u91ce\u6751 \u667a\u7fa9\u3089(2014). \u30d5\u30c3\u5316\u7269\u5165\u308a\u30da\u30fc\u30b9\u30c8\u304c\u30c1\u30bf\u30f3\u306e\u8010\u98df\u6027\u306b\u4e0e\u3048\u308b\u5f71\u97ff \u65e5\u53e3\u8154\u30a4\u30f3\u30d7\u30e9\u30f3\u30c8\u4f1a\u8a8c27-1 P54-60<\/p>\n<p>22) FAQ(\u3088\u304f\u3042\u308b\u3054\u8cea\u554f) \u30aa\u30fc\u30e9\u30eb\u30b1\u30a2https:\/\/www.oralcare.co.jp\/faq\/\u3000(Retrieved on september8, 2021)<\/p>\n<p>23) \u5929\u91ce\u6566\u96c4\u3089 (2012) \u30d3\u30b8\u30e5\u30a2\u30eb\u6b6f\u5468\u75c5\u3092\u79d1\u5b66\u3059\u308b\u3000\u30af\u30a4\u30f3\u30c6\u30c3\u30bb\u30f3\u30b9\u51fa\u7248<\/p>\n<p>24) \u5965\u7530\u514b\u723e\u3000(2020) \u30c7\u30f3\u30bf\u30eb\u30d7\u30e9\u30fc\u30af\u306e\u3059\u3079\u3066 \u533b\u6b6f\u85ac\u51fa\u7248<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<h2>\uff18\uff0e\u95a2\u9023\u8a18\u4e8b<\/h2>\n<p><a title=\"\u3010\u30a8\u30d3\u30c7\u30f3\u30b9\u3011\u306a\u305c\u5927\u4eba\u306e\u6b6f\u306b\u3053\u305d\u30d5\u30c3\u5316\u7269\u5fdc\u7528\u304c\u5fc5\u8981\u306a\u306e\u304b\uff1f\" href=\"https:\/\/yobou.work\/?p=924\">\u3010\u30a8\u30d3\u30c7\u30f3\u30b9\u3011\u306a\u305c\u5927\u4eba\u306e\u6b6f\u306b\u3053\u305d\u30d5\u30c3\u5316\u7269\u5fdc\u7528\u304c\u5fc5\u8981\u306a\u306e\u304b\uff1f<\/a><\/p>\n<p><a title=\"\u3048\u3063!?\u306a\u3093\u3067\u30d5\u30c3\u5316\u7269(\u30d5\u30c3\u7d20)\u6d17\u53e3\u3057\u3066\u306a\u3044\u306e\uff1f\uff1f\u30d5\u30c3\u5316\u7269\u6d17\u53e3\u3092\u304a\u85a6\u3081\u3059\u308b\u7406\u7531\" href=\"https:\/\/yobou.work\/?p=461\">\u3048\u3063!?\u306a\u3093\u3067\u30d5\u30c3\u5316\u7269(\u30d5\u30c3\u7d20)\u6d17\u53e3\u3057\u3066\u306a\u3044\u306e\uff1f\uff1f\u30d5\u30c3\u5316\u7269\u6d17\u53e3\u3092\u304a\u85a6\u3081\u3059\u308b\u7406\u7531<\/a><\/p>\n<p><a title=\"\u3010\u30a8\u30d3\u30c7\u30f3\u30b9\u3011\u6b6f\u306e\u30d5\u30c3\u7d20\u75c7(\u6591\u72b6\u6b6f)\u306f\u30d5\u30c3\u5316\u7269\u6d17\u53e3\u3084\u30d5\u30c3\u5316\u7269\u914d\u5408\u6b6f\u78e8\u5264\u3067\u8d77\u3053\u308b\u306e\u304b\uff1f\" href=\"https:\/\/yobou.work\/?p=860\">\u3010\u30a8\u30d3\u30c7\u30f3\u30b9\u3011\u6b6f\u306e\u30d5\u30c3\u7d20\u75c7(\u6591\u72b6\u6b6f)\u306f\u30d5\u30c3\u5316\u7269\u6d17\u53e3\u3084\u30d5\u30c3\u5316\u7269\u914d\u5408\u6b6f\u78e8\u5264\u3067\u8d77\u3053\u308b\u306e\u304b\uff1f<\/a><\/p>\n<p>&nbsp;<\/p>\n<h2>\u00a0<\/h2>\n<h2>\uff19\uff0e\u304a\u3059\u3059\u3081<\/h2>\n<p>\u30d5\u30c3\u5316\u7b2c\u4e00\u30b9\u30ba\u6b6f\u78e8\u5264\u306f\u3044\u304b\u306b\u7279\u6709\u306e\u91d1\u5c5e\u5473\u3092\u30de\u30b9\u30af\u3067\u304d\u308b\u304b\uff0e<br 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