{"id":1627,"date":"2023-01-21T16:27:31","date_gmt":"2023-01-21T07:27:31","guid":{"rendered":"https:\/\/yobou.work\/?p=1627"},"modified":"2023-09-29T13:13:12","modified_gmt":"2023-09-29T04:13:12","slug":"%e3%80%90%e3%82%a8%e3%83%93%e3%83%87%e3%83%b3%e3%82%b9%e3%80%91%e5%96%ab%e7%85%99%e3%81%af%e3%81%86%e8%9d%95%e3%81%ae%e5%8e%9f%e5%9b%a0%e3%81%ab%e3%81%aa%e3%82%8b%e3%81%8b%ef%bc%9f%e3%80%80%ef%bd%9e","status":"publish","type":"post","link":"https:\/\/yobou.work\/?p=1627","title":{"rendered":"\u3010\u30a8\u30d3\u30c7\u30f3\u30b9\u3011\u55ab\u7159\u306f\u3046\u8755\u306e\u539f\u56e0\u306b\u306a\u308b\u304b\uff1f\u3000\uff5e\u305d\u306e\u539f\u56e0\u3068\u53d7\u52d5\u55ab\u7159\u30fb\u53e3\u8154\u4e7e\u71e5\u75c7\u3068\u306e\u95a2\u9023\u306b\u3064\u3044\u3066\uff5e"},"content":{"rendered":"<p><img data-recalc-dims=\"1\" decoding=\"async\" class=\"aligncenter size-large wp-image-1628\" src=\"https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2023\/01\/DSC01206.jpg?resize=665%2C499\" alt=\"\" width=\"665\" height=\"499\" srcset=\"https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2023\/01\/DSC01206.jpg?resize=1024%2C768&amp;ssl=1 1024w, https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2023\/01\/DSC01206.jpg?resize=300%2C225&amp;ssl=1 300w, https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2023\/01\/DSC01206.jpg?resize=768%2C576&amp;ssl=1 768w, https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2023\/01\/DSC01206.jpg?resize=1536%2C1152&amp;ssl=1 1536w, https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2023\/01\/DSC01206.jpg?resize=660%2C495&amp;ssl=1 660w, https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2023\/01\/DSC01206.jpg?w=1920&amp;ssl=1 1920w, https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2023\/01\/DSC01206.jpg?w=1330 1330w\" sizes=\"(max-width: 665px) 100vw, 665px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p>\u3000\u55ab\u7159\u3059\u308b\u3053\u3068\u306b\u3088\u308a\uff0c\u6b6f\u5468\u75c5\u306f\u3082\u3061\u308d\u3093\uff0c\u3046\u8755\u306b\u7f79\u60a3\u3059\u308b\u30ea\u30b9\u30af\u304c\u5897\u52a0\u3059\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u304d\u307e\u3057\u305f\uff0e\u4eca\u56de\u306f\u55ab\u7159\u306b\u3088\u308b\u3046\u8755\u306e\u5f71\u97ff\u306b\u3064\u3044\u3066\u30a8\u30d3\u30c7\u30f3\u30b9\u3068\u3068\u3082\u306b\u7d10\u89e3\u3044\u3066\u307f\u305f\u3044\u3068\u601d\u3044\u307e\u3059\uff0e\u306a\u304a\uff0c\u5185\u5bb9\u306e\u6b63\u78ba\u6027\u306b\u3064\u3044\u3066\u306f\u6c17\u3092\u4ed8\u3051\u3066\u304a\u308a\u307e\u3059\u304c\uff0c\u8aa4\u8a33\u7b49\u3042\u308a\u307e\u3057\u305f\u3089\u304a\u77e5\u3089\u305b\u3044\u305f\u3060\u3051\u308c\u3070\u5e78\u3044\u3067\u3059\uff0e\u307e\u305f\uff0c\u771f\u507d\u7b49\u306f\u5404\u81ea\u3067\u3054\u5224\u65ad\u3044\u305f\u3060\u304d\u307e\u3059\u3088\u3046\u304a\u9858\u3044\u7533\u3057\u4e0a\u3052\u307e\u3059\uff0e<\/p>\n<p>&nbsp;<\/p>\n<h2><strong>\uff11\uff0e\u306a\u305c\u55ab\u7159\u3067\u3046\u8755\u304c\u5897\u52a0\u3059\u308b\u306e\u304b<\/strong><\/h2>\n<p>\u3000\u8907\u6570\u306e\u7814\u7a76\u3067\uff0c\u55ab\u7159\u306b\u3088\u3063\u3066\u3046\u8755\u304c\u5897\u52a0\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059<sup>1),2),3)<\/sup>\uff0e\u672c\u6570\u304c\u591a\u3051\u308c\u3070\u591a\u3044\u307b\u3069\u3046\u8755\u304c\u5897\u52a0\u3059\u308b\u3068\u306e\u5831\u544a\u3082\u3042\u308a\u307e\u3059<sup>4)<\/sup>\uff0e\u306a\u305c\u55ab\u7159\u3059\u308b\u3068\u3046\u8755\u304c\u5897\u3048\u308b\u306e\u304b\uff0c\u5b9f\u306f\u307e\u3060\u305d\u306e\u7d50\u8ad6\u306f\u51fa\u3066\u3044\u306a\u3044\u306e\u3067\u3059\u304c\uff0c\u305d\u306e\u3042\u305f\u308a\u3092pubmed\u7b49\u3067\u691c\u7d22\u3057\u3066\u307f\u307e\u3057\u305f\uff0e<\/p>\n<p>&nbsp;<\/p>\n<p><strong>1-1 <\/strong><strong>\u30cb\u30b3\u30c1\u30f3\u304c\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b<\/strong><\/p>\n<p>\u3000\u7c73\u56fd\u30a4\u30f3\u30c7\u30a3\u30a2\u30ca\u5927\u5b66\u306e\u7814\u7a76\u8005\u306f\uff0c\u30bf\u30d0\u30b3\u306b\u542b\u307e\u308c\u308b\u30cb\u30b3\u30c1\u30f3\u306e\u5f71\u97ff\u306b\u3088\u308a\uff0c\u3046\u8755\u75c5\u539f\u83cc\u3067\u3042\u308b<em>S.mutans<\/em>\u306e\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u304c\u539a\u304f\u306a\u308b\u3053\u3068\u304c\u89b3\u5bdf\u3055\u308c\uff0c\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u5f62\u6210\u3068\u4ee3\u8b1d\u6d3b\u6027\u3092\u4ea2\u9032\u3055\u305b\u308b\u3068\u5831\u544a\u3057\u3066\u3044\u307e\u3059<sup>5)<\/sup>\uff0ein vitro \u3067\u30cb\u30b3\u30c1\u30f3\u306f<em>S.mutans<\/em> \u304a\u3088\u3073<em> S.sanguis<\/em> \u3092\u5897\u52a0\u3055\u305b\u308b\uff0e\u3068\u3059\u308b\u7814\u7a76\u3082\u3042\u308a\u307e\u3059<sup>6)<\/sup>\uff0e\u3082\u3061\u308d\u3093\uff0c\u3046\u8755\u306f\u591a\u56e0\u5b50\u75be\u60a3\u306a\u306e\u3067\uff0c\u3053\u306e\u30cb\u30b3\u30c1\u30f3\u304c\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3068\u3044\u3046\u7d50\u679c\u306f\u4e00\u3064\u306e\u8981\u56e0\u3067\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308a\u307e\u3059\uff0e<\/p>\n<p>&nbsp;<\/p>\n<p><strong>1-2 <\/strong><strong>\u514d\u75ab\u7269\u8cea\u3067\u3042\u308bsIgA\u304c\u6e1b\u5c11\u3059\u308b<\/strong><\/p>\n<p>\u3000\u3046\u8755\u306b\u306a\u308a\u306b\u304f\u3044\u4eba\u306f\u7c98\u819c\u4e0a\u76ae\u3084\u817a\u4e0a\u76ae\u306e\u5c40\u6240\u3067\u751f\u5408\u6210\u3055\u308c\uff0c\u5c40\u6240\u514d\u75ab\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u6301\u3064\u514d\u75ab\u7269\u8cea\u3067\u3042\u308b\u553e\u6db2\u4e2d\u306esIgA\u304c\u591a\u304b\u3063\u305f\u3068\u3044\u3046\u5831\u544a<sup>7)<\/sup>\u304c\u3042\u308a\u307e\u3059\uff0e\u55ab\u7159\u8005\u3067\u306f\u3053\u306esIgA\u304c\u4f4e\u6fc3\u5ea6\u3060\u3063\u305f\u3068\u306e\u5831\u544a\u304c\u3042\u308a\u307e\u3059<sup>8)<\/sup>\uff0e\u55ab\u7159\u306b\u3088\u308asIgA\u304c\u6e1b\u5c11\u3057\uff0c\u3046\u8755\u75c5\u539f\u6027\u7d30\u83cc\u304c\u5897\u52a0\u3059\u308b\u3053\u3068\u3067\u3046\u8755\u304c\u5897\u52a0\u3059\u308b\u3068\u3044\u3046\u53ef\u80fd\u6027\u306f\u3042\u308b\u3068\u601d\u3044\u307e\u3059\uff0e<\/p>\n<p>&nbsp;<\/p>\n<p><strong>1-3 <\/strong><strong>\u55ab\u7159\u3059\u308b\u3068\u553e\u6db2pH\u304c\u4f4e\u304f\u306a\u308b<\/strong><\/p>\n<p>\u3000\u55ab\u7159\u8005\u306e\u553e\u6db2pH\u306f6.75\uff08\u00b10.11\uff09\uff0c\u975e\u55ab\u7159\u80057.00\uff08\u00b10.28\uff09\u3068\u6bd4\u8f03\u3057\u3066\u6709\u610f\u306b\u4f4e\u304b\u3063\u305f<sup>9)<\/sup>\u3068\u5831\u544a\u304c\u3042\u308a\u307e\u3059\uff0e\u3053\u306e\u5fae\u5999\u306apH\u306e\u4f4e\u4e0b\u304c\u3069\u306e\u7a0b\u5ea6\u3046\u8755\u306b\u95a2\u4e0e\u3059\u308b\u304b\u306f\u4e0d\u660e\u3067\u3059\u304c\uff0c\u76f4\u63a5\u7684\u306b\u8131\u7070\u3055\u305b\u306a\u3044\u3068\u3057\u3066\u3082\u98f2\u98df\u7269\u306e\u5f71\u97ff\u7b49\u3068\u76f8\u307e\u3063\u3066\u76f8\u52a0\u7684\u306b\u4f5c\u7528\u3059\u308b\u53ef\u80fd\u6027\u306f\u3042\u308b\u306e\u304b\u306a\u3068\u601d\u3044\u307e\u3059\uff0e<\/p>\n<p>&nbsp;<\/p>\n<p><strong>1-4 <\/strong><strong>\u30cb\u30b3\u30c1\u30f3\u306b\u3088\u3063\u3066\u53e3\u8154\u4e7e\u71e5\u304c\u8d77\u3053\u308b<\/strong><\/p>\n<p>\u3000\u53e3\u8154\u4e7e\u71e5\u75c7\u3092\u3082\u3064\u60a3\u8005\u3055\u3093\u306f\u3046\u8755\u7f79\u60a3\u7387\u304c\u5897\u52a0\u3059\u308b\u3053\u3068\u306f\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059<sup>10)<\/sup>.\u305d\u3057\u3066\uff0c\u4eca\u56de\u3042\u3089\u305f\u3081\u3066\u691c\u7d22\u3057\u3066\u55ab\u7159\u3059\u308b\u3068\u30cb\u30b3\u30c1\u30f3\u306e\u4f5c\u7528\u3067\u553e\u6db2\u5206\u6ccc\u304c\u6291\u5236\u3055\u308c\u308b\u3068\u3044\u3046\u8a18\u4e8b\u3092Web\u4e0a\u3067\u3088\u304f\u898b\u304b\u3051\u307e\u3057\u305f\uff0e<\/p>\n<p>\u3000\u78ba\u304b\u306b\u6587\u732e\u7684\u306b\u3082\u55ab\u7159\u8005\u306f\u553e\u6db2\u5206\u6ccc\u304c\u5c11\u306a\u304b\u3063\u305f\u3068\u306e\u5831\u544a\u3082\u76ee\u306b\u3057\u307e\u3057\u305f<sup>11)<\/sup>\uff0e\u3057\u304b\u3057\uff0c\u305d\u306e\u30cb\u30b3\u30c1\u30f3\u304c\u553e\u6db2\u5206\u6ccc\u3092\u6291\u5236\u3057\u53e3\u8154\u4e7e\u71e5\u3092\u60f9\u8d77\u3059\u308b\u3068\u3044\u3046\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u8abf\u3079\u3088\u3046\u3068\u3057\u3066\u3082\uff0c\u305d\u308c\u3092\u88cf\u4ed8\u3051\u308b\u57fa\u790e\u7814\u7a76\u3092\u898b\u3064\u3051\u308b\u3053\u3068\u304c\u51fa\u6765\u307e\u305b\u3093\u3067\u3057\u305f\uff0e\u55ab\u7159\u3068\u553e\u6db2\u5206\u6ccc\u306e\u95a2\u4fc2\u6027\u306b\u3064\u3044\u3066\u306f\u5f8c\u8ff0\u3057\u305f\u3044\u3068\u601d\u3044\u307e\u3059\uff0e<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<h2><strong>2\uff0e\u55ab\u7159(\u30cb\u30b3\u30c1\u30f3)\u306f\u553e\u6db2\u5206\u6ccc\u91cf\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u304b\uff1f<\/strong><\/h2>\n<p><strong>2-1 <\/strong><strong>\u55ab\u7159\u306f\u553e\u6db2\u5206\u6ccc\u91cf\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3068\u3044\u3046\u7814\u7a76<\/strong><\/p>\n<p>\u3000\u30a4\u30f3\u30c9\u306e120\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u305f\u81e8\u5e8a\u7814\u7a76\u3067\u306f\uff0c\u53e3\u8154\u4e7e\u71e5\u75c7\u72b6\u306e\u6709\u75c5\u7387\u306f\uff0c\u55ab\u7159\u8005\u306737\uff05\uff0c\u975e\u55ab\u7159\u8005\u306713\uff05\u3067\u3042\u308a\u55ab\u7159\u304c\u53e3\u8154\u4e7e\u71e5\u75c7\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3068\u5831\u544a\u3057\u3066\u3044\u307e\u3059<sup>12)<\/sup>\uff0e\u307e\u305f\uff0c\u30a4\u30e9\u30f3\u306e200\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u305f\u81e8\u5e8a\u7814\u7a76\u3067\u306f\uff0c\u5e73\u5747\u553e\u6db2\u91cf\u304c\u55ab\u7159\u8005\u304c1\u5206\u9593\u306b0.38ml\u3067\uff0c\u975e\u55ab\u7159\u8005\u304c1\u5206\u9593\u306b0.56ml\u3067\u7d71\u8a08\u5b66\u7684\u306b\u6709\u610f\u306a\u5dee\u304c\u8a8d\u3081\u3089\u308c\u305f\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff0e\u307e\u305f\uff0c\u3053\u306e\u7814\u7a76\u3067\u306f\u3046\u8755\u3084\u6b6f\u8089\u708e\u306a\u3069\u306e\u53e3\u8154\u5185\u75c5\u5909\u304c\u55ab\u7159\u8005\u3067\u6709\u610f\u306b\u9ad8\u7387\u3060\u3063\u305f\u3068\u5831\u544a\u3057\u3066\u3044\u307e\u3059<sup>11)<\/sup>\uff0e\u553e\u6db2\u306e\u8cea\u306e\u9055\u3044\u3082\u5831\u544a\u3055\u308c\uff0c\u55ab\u7159\u8005\u306f\u6fc3\u3044(\u7c98\u6db2\u6027)\u553e\u6db2\uff0c\u975e\u55ab\u7159\u8005\u306f\u6f3f\u6db2\u304c\u4e3b\u4f53\u3067\u3042\u308b<sup>13)<\/sup>\u3068\u3059\u308b\u7814\u7a76\u3084\uff0c\u5973\u6027\u55ab\u7159\u8005\u306f\u7537\u6027\u55ab\u7159\u8005\u3088\u308a\u3082\u30c9\u30e9\u30a4\u30de\u30a6\u30b9\u306b\u306a\u308b\u78ba\u7387\u304c\u9ad8\u304b\u3063\u305f<sup>14)<\/sup>\u3068\u3044\u3046\u7814\u7a76\u3082\u76ee\u306b\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\uff0e<\/p>\n<p>\u3000\u3069\u3046\u3057\u3066\u55ab\u7159\u304c\u553e\u6db2\u5206\u6ccc\u91cf\u3092\u6e1b\u5c11\u3055\u305b\uff0c\u53e3\u8154\u4e7e\u71e5\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u306e\u304b\uff0c\u30bf\u30d0\u30b3\u306e\u3069\u306e\u6210\u5206\u304c\u305d\u3046\u3044\u3046\u4f5c\u7528\u3092\u53ca\u307c\u3057\u3066\u3044\u308b\u306e\u304b\u306b\u3064\u3044\u3066\u57fa\u790e\u7814\u7a76\u304c\u306a\u3044\u304b\u8abf\u3079\u3066\u307f\u307e\u3057\u305f\u304c\uff0c\u3053\u308c\u3068\u8a00\u3063\u305f\u7814\u7a76\u3092\u898b\u3064\u3051\u308b\u3053\u3068\u306f\u51fa\u6765\u307e\u305b\u3093\u3067\u3057\u305f\uff0e<\/p>\n<p>&nbsp;<\/p>\n<p><strong>2-2 <\/strong><strong>\u55ab\u7159\u306f\u553e\u6db2\u5206\u6ccc\u91cf\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3055\u306a\u3044\u3068\u3044\u3046\u7814\u7a76<\/strong><\/p>\n<p>\u3000\u55ab\u7159\u306f\u553e\u6db2\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3068\u3044\u3046\u7814\u7a76\u306e\u4e00\u65b9\uff0c\u55ab\u7159\u306f\u553e\u6db2\u5206\u6ccc\u306b\u60aa\u5f71\u97ff\u3092\u53ca\u307c\u3055\u306a\u3044\u3068\u3059\u308b\u8ad6\u6587\u3082\u3042\u308a\u307e\u3059<sup>15)16)17)<\/sup>\uff0e\u30e9\u30c3\u30c8\u3092\u7528\u3044\u305f\u65e5\u672c\u306e\u57fa\u790e\u7814\u7a76\u3067\u306f\u55ab\u7159\u3068\u975e\u55ab\u7159\u306e\u523a\u6fc0\u553e\u6db2\u306b\u306f\u5dee\u304c\u7121\u304b\u3063\u305f\u3068\u3057\u3066\u3044\u307e\u3059<sup>18)<\/sup>\uff0e<\/p>\n<p>&nbsp;<\/p>\n<p><strong>2-3 <\/strong><strong>\u55ab\u7159\u306b\u3088\u3063\u3066\u553e\u6db2\u5206\u6ccc\u91cf\u304c\u5897\u52a0\u3057\u305f\u3068\u3044\u3046\u7814\u7a76<\/strong><\/p>\n<p>\u30001971\u5e74\u306b\u5831\u544a\u3055\u308c\u305f\u7814\u7a76\u3067\u306f\uff0c\u55ab\u7159\u884c\u70ba\u306b\u3088\u308a\u55ab\u7159\u8005\u3082\u975e\u55ab\u7159\u8005\u3082\u8033\u4e0b\u817a\u553e\u6db2\u304c\u5927\u5e45\u306b\u5897\u52a0\u3057\u305f\u3068\u8a18\u8f09\u3055\u308c\u3066\u3044\u307e\u3059\uff0e\u30bf\u30d0\u30b3\u306e\u523a\u6fc0\u7269\u8cea\u306b\u3088\u3063\u3066\u5206\u6ccc\u4fc3\u9032\u306b\u81f3\u3063\u305f\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u7d50\u8ad6\u4ed8\u3051\u3089\u308c\u3066\u3044\u307e\u3059<sup>19)<\/sup>\uff0e\u307e\u305f\uff0c\u30e9\u30c3\u30c8\u3092\u7528\u3044\u305f\u57fa\u790e\u7814\u7a76\u3067\u306f\uff0c\u30bf\u30d0\u30b3\u3084\u30cb\u30b3\u30c1\u30f3\u304c\u8033\u4e0b\u817a\u306e\u553e\u6db2\u5206\u6ccc\u3092\u4fc3\u9032\u3059\u308b\u306e\u306f\uff0c\u03b13\u03b24\u30cb\u30b3\u30c1\u30f3\u53d7\u5bb9\u4f53\u30b5\u30d6\u30bf\u30a4\u30d7\u306e\u6d3b\u6027\u5316\u3092\u4ecb\u3057\u3066\u81ea\u5f8b\u795e\u7d4c\u672b\u7aef\u304b\u3089\u30a2\u30bb\u30c1\u30eb\u30b3\u30ea\u30f3\u3068\u30ce\u30eb\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u304c\u653e\u51fa\u3055\u308c\u308b\u304b\u3089<sup>20)<\/sup>\uff0e\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff0e\u3061\u306a\u307f\u306b\u30a2\u30bb\u30c1\u30eb\u30b3\u30ea\u30f3\u306f\u526f\u4ea4\u611f\u523a\u6fc0\u3067\u653e\u51fa\u3055\u308c\uff0c\u30ce\u30eb\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u306f\u4ea4\u611f\u795e\u7d4c\u523a\u6fc0\u3067\u653e\u51fa\u3055\u308c\u307e\u3059\uff0e\u526f\u4ea4\u611f\u523a\u6fc0\u3067\u653e\u51fa\u3055\u308c\u305f\u30a2\u30bb\u30c1\u30eb\u30b3\u30ea\u30f3\u306f\u30e0\u30b9\u30ab\u30ea\u30f3\u53d7\u5bb9\u4f53\u3068\u7d50\u5408\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u553e\u6db2\u4e2d\u306e\u6c34\u5206\u6ccc\u304c\u8d77\u3053\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\uff0e<\/p>\n<p>\u3000\u4e00\u822c\u7684\u306b\uff0c\u55ab\u7159\u7fd2\u6163\u306e\u3042\u308b\u4eba\u306f\u55ab\u7159\u884c\u52d5\u306b\u3088\u308a\u4e3b\u306b\u526f\u4ea4\u611f\u795e\u7d4c\u304c\u523a\u6fc0\u3055\u308c\uff0c\u553e\u6db2\u4e2d\u306e\u6c34\u6210\u5206\u306f\u5206\u6ccc\u3055\u308c\u308b\u65b9\u5411\u306b\uff0c\u666e\u6bb5\u55ab\u7159\u3059\u308b\u7fd2\u6163\u304c\u306a\u3044\u4eba\u306b\u3068\u3063\u3066\u306f\u3069\u3061\u3089\u304b\u3068\u3044\u3046\u3068\u4ea4\u611f\u795e\u7d4c\u304c\u523a\u6fc0\u3055\u308c\uff0c\u553e\u6db2\u4e2d\u306e\u30bf\u30f3\u30d1\u30af\u6210\u5206\u306e\u5206\u6ccc\u306b\u50be\u304d\uff0c\u553e\u6db2\u306e\u5b9f\u8cea\u7684\u306a\u6c34\u6210\u5206\u306f\u6291\u5236\u3055\u308c\u308b\u3068\u3082\u8003\u3048\u3089\u308c\u307e\u3059\uff0e\u3044\u305a\u308c\u306b\u3057\u3066\u3082\u57fa\u790e\u7814\u7a76\u3067\u55ab\u7159\u3084\u30cb\u30b3\u30c1\u30f3\u304c\u553e\u6db2\u817a\u306e\u5206\u6ccc\u3092\u4fc3\u9032\u3059\u308b\/\u6291\u5236\u3059\u308b\u3068\u8a00\u3063\u305f\u4f5c\u7528\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u89e3\u660e\u3055\u308c\u3066\u3044\u306a\u3044\u3068\u3044\u3046\u306e\u304c\u7d50\u8ad6\u3067\u3059\uff0e<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<h2><strong>3\uff0e\u89aa\u304c\u55ab\u7159\u3059\u308b\u3068\u5b50\u306f\u3046\u8755\u304c\u5897\u52a0\u3059\u308b\u304b(\u53d7\u52d5\u55ab\u7159)<\/strong><\/h2>\n<p>\u3000\u55ab\u7159\u3057\u3066\u3044\u308b\u89aa\u306b\u990a\u80b2\u3055\u308c\u305f\u5b50\u306b\u306f\u3046\u8755\u304c\u591a\u3044\u3068\u3059\u308b\u8ad6\u6587\u304c\u3042\u308a\u307e\u3059<sup>21)22)23) 24) 25)<\/sup>\uff0e\u3055\u3089\u306b\u6bcd\u89aa\u304c\u598a\u5a20\u4e2d\u306e\u55ab\u7159\u3082\uff0c\u5b50\u306e\u3046\u8755\u306e\u5897\u52a0\u3068\u95a2\u9023\u6027\u304c\u5f97\u3089\u308c\u3066\u3044\u307e\u3059<sup>26)27)28)<\/sup>\uff0e\u30bf\u30d0\u30b3\u306e\u5f71\u97ff\u3092\u53d7\u3051\u3084\u3059\u3044\u5e7c\u5150\u306f\u53d7\u52d5\u55ab\u7159\u306b\u3088\u3063\u3066\u3046\u8755\u304c\u591a\u304f\u306a\u3063\u3066\u3057\u307e\u3046\u306e\u3067\u3057\u3087\u3046\u304b\uff0e\u305d\u3057\u3066\uff0c\u7236\u89aa\u3088\u308a\u3082\u6bcd\u89aa\u306e\u55ab\u7159\u3068\u306e\u95a2\u9023\u306e\u65b9\u304c\u9ad8\u3044\u3068\u3044\u3046\u8ad6\u6587\u304c\u3042\u308a\u307e\u3059<sup>29)30)<\/sup>\uff0e<\/p>\n<p>\u3000\u305d\u306e\u7406\u7531\u306b\u3064\u3044\u3066\uff0c\u53d7\u52d5\u55ab\u7159\u306f\u4e3b\u306b\u30d7\u30e9\u30fc\u30af\u306e\u84c4\u7a4d\u3092\u5897\u52a0\u3055\u305b\u308b\u52b9\u679c\u304c\u3042\u308a\uff0c\u6b21\u306b\u53d7\u52d5\u55ab\u7159\u8005\u304c\u53e3\u8154\u5185\u306e\u751f\u7406\u7684\u69cb\u9020\u306a\u3069\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u305f\u3081\u3068\u601d\u308f\u308c\u308b<sup>31)<\/sup>\u3068\u8003\u5bdf\u3055\u308c\u3066\u3044\u307e\u3059\uff0e\u81e8\u5e8a\u7814\u7a76\u306a\u306e\u3067\uff0c\u305d\u308c\u4ee5\u4e0a\u306e\u3053\u3068\u306f\u306a\u3044\u306e\u3067\u3059\u304c\uff0c\u3055\u3089\u306b\u8abf\u3079\u3066\u307f\u3066\u3082\u3053\u308c\u4ee5\u4e0a\u306e\u8003\u5bdf\u306f\u898b\u3064\u3051\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\uff0e<\/p>\n<p>\u3000\u3082\u3061\u308d\u3093\uff0c\u55ab\u7159\u306b\u3088\u308b\u76f4\u63a5\u7684\u306a\u6709\u5bb3\u4e8b\u8c61\u3082\u3042\u308b\u306e\u304b\u306a\u3068\u306f\u601d\u3046\u306e\u3067\u3059\u304c\uff0c\u5b50\u306e\u5065\u5eb7\u306e\u305f\u3081\u306b\u55ab\u7159\u3057\u306a\u3044\u3068\u3044\u3046\u5065\u5eb7\u610f\u8b58\u3092\u6301\u3064\u89aa\u304b\u3089\u51fa\u751f\u30fb\u990a\u80b2\u3055\u308c\u305f\u5b50\u4f9b\u3068\uff0c\u5b50\u3078\u306e\u5f71\u97ff\u3092\u8003\u3048\u305a\u55ab\u7159\u3059\u308b\u89aa\u304b\u3089\u51fa\u751f\u30fb\u990a\u80b2\u3055\u308c\u305f\u5b50\u4f9b\u3063\u3066\u3044\u3046\uff0c\u305d\u3046\u3044\u3046\u30d0\u30a4\u30a2\u30b9\u304c\u3042\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u8003\u3048\u3066\u3057\u307e\u3044\u307e\u3059\uff0e<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<h2><strong>\uff14\uff0e\u52a0\u71b1\u5f0f\u30bf\u30d0\u30b3\uff0c\u96fb\u5b50\u30bf\u30d0\u30b3\u306f\u3046\u8755\u306e\u539f\u56e0\u3068\u306a\u308b\u304b<\/strong><\/h2>\n<p>\u3000\u6570\u5e74\u524d\u304b\u3089\u975e\u71c3\u713c\u5f0f\u30bf\u30d0\u30b3\u304c\u666e\u53ca\u3057\u3066\u3044\u307e\u3059\uff0e\u71c3\u713c\u3057\u306a\u3044\u5206\uff0c\u526f\u6d41\u7159\u306e\u554f\u984c\u3092\u306f\u3058\u3081\u69d8\u3005\u306a\u8ca0\u62c5\u304c\u5c11\u306a\u3044\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\uff0e\u975e\u71c3\u713c\u5f0f\u30bf\u30d0\u30b3\u3092\u5927\u304d\u304f\u5206\u985e\u3059\u308b\u3068\u30bf\u30d0\u30b3\u8449\u3092\u52a0\u71b1\u3059\u308b\u52a0\u71b1\u5f0f\u30bf\u30d0\u30b3\uff0c\u30b0\u30ea\u30bb\u30ed\u30fc\u30eb\u3084PG\u3092\u52a0\u71b1\u3057\u3066\u30a8\u30a2\u30ed\u30be\u30eb\u3092\u767a\u751f\u3055\u305b\u308b\u96fb\u5b50\u30bf\u30d0\u30b3\u306b\u5927\u5225\u3055\u308c\u307e\u3059\uff0e<\/p>\n<p><strong>4-1 <\/strong><strong>\u52a0\u71b1\u5f0f\u30bf\u30d0\u30b3<\/strong><\/p>\n<p>\u3000\u30d5\u30a3\u30ea\u30c3\u30d7\u30e2\u30ea\u30b9\u306eIQOS\uff0cJT\u306ePloomTECH\uff0c\u304c\u4ee3\u8868\u4f8b\u3067\u3059\uff0e\u52a0\u71b1\u5f0f\u30bf\u30d0\u30b3\u306e\u5316\u5b66\u7269\u8cea\u306fPG\uff0c\u30b0\u30ea\u30bb\u30ed\u30fc\u30eb\uff0c\u30a2\u30bb\u30c8\u2015\u30eb\u3092\u9664\u3044\u3066\u71c3\u713c\u5f0f\u30bf\u30d0\u30b3\u3088\u308a\u3082\u5c11\u306a\u3044\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\uff0e\u5f53\u7136\uff0c\u30bf\u30d0\u30b3\u306e\u8449\u3092\u52a0\u71b1\u3059\u308b\u306e\u3067\u69d8\u3005\u306a\u6709\u5bb3\u7269\u8cea\u304c\u767a\u751f\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\uff0e\u30cb\u30b3\u30c1\u30f3\u306f\u71c3\u713c\u5f0f\u306e\u534a\u5206\u4ee5\u4e0b\u3060\u3063\u305f\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059<sup>32)<\/sup>\u71c3\u713c\u3057\u306a\u3044\u307e\u3067\u3082\u71c3\u713c\u5f0f\u3068\u540c\u3058\u30bf\u30d0\u30b3\u8449\u3092\u4f7f\u7528\u3059\u308b\u308f\u3051\u3067\u3059\u304b\u3089\uff0c\u3084\u306f\u308a\u3046\u8755\u3068\u306e\u95a2\u4fc2\u6027\u306f\u3042\u308b\u306e\u304b\u306a\u3068\u601d\u3044\u307e\u3059\uff0e<\/p>\n<p>&nbsp;<\/p>\n<p><strong>4-2 <\/strong><strong>\u96fb\u5b50\u5f0f\u30bf\u30d0\u30b3<\/strong><\/p>\n<p>\u3000\u96fb\u5b50\u5f0f\u30bf\u30d0\u30b3\u306f\u65e5\u672c\u3067\u306f\u30cb\u30b3\u30c1\u30f3\u306e\u4f7f\u7528\u304c\u85ac\u6a5f\u6cd5\u306b\u3088\u308a\u7981\u6b62\u3055\u308c\u3066\u3044\u308b\u306e\u3067\uff0c\u542b\u307e\u308c\u3066\u3044\u307e\u305b\u3093\uff0e\u3057\u304b\u3057\uff0c\u30a8\u30a2\u30ed\u30be\u30eb\u304c\u5927\u91cf\u767a\u751f\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u547c\u5438\u5668\u75be\u60a3\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff0e\u96fb\u5b50\u30bf\u30d0\u30b3\u304b\u3089\u767a\u751f\u3059\u308bPG\u3084\u30b0\u30ea\u30bb\u30ed\u30fc\u30eb\uff0c\u30db\u30eb\u30e0\u30a2\u30eb\u30c7\u30d2\u30c9\uff0c\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u306a\u3069\u306e\u30a8\u30a2\u30ed\u30be\u30eb\u306f2\u03bcm\u4ee5\u4e0b\u306e\u5fae\u7c92\u5b50\u304c97%\u3092\u5360\u3081\uff0c\u55ab\u7159\u8005\u306e\u80ba\u80de\u307e\u3067\u9054\u3057\u3084\u3059\u304f\u7528\u610f\u306b\u4f53\u5185\u306b\u5438\u53ce\u3055\u308c\u308b\u3053\u3068\u304b\u3089\u5065\u5eb7\u3078\u306e\u5f71\u97ff\u304c\u61f8\u5ff5\u3055\u308c\u308b\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059<sup>32)<\/sup>\uff0e<\/p>\n<p>\u3000\u307e\u305f\uff0c\u96fb\u5b50\u5f0f\u30bf\u30d0\u30b3\u306b\u306f\u30b7\u30e7\u7cd6\u3084\u9999\u6599\u306a\u3069\u304c\u542b\u307e\u308c\u3066\u304a\u308a\uff0c\u3046\u8755\u3068\u306e\u95a2\u9023\u6027\u3092\u793a\u3059\u6587\u732e\u304c\u5b58\u5728\u3057\u3066\u3044\u307e\u3059<sup>33)<\/sup>\uff0e\u307e\u305f\uff0c<em>S. mutans<\/em>\u306e\u5897\u6b96\u3001\u304a\u3088\u3073\u75c5\u539f\u6027\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u5897\u52a0\uff0c\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u306e\u5f62\u6210\u4fc3\u9032\u304c\u5831\u544a\u3055\u308c\u3066\u304a\u308a<sup>34)<\/sup>\uff0c\u3055\u3089\u306b\u7c73\u56fd\u306e\u7814\u7a76\u8005\u306b\u3088\u308a2022\u5e74\u306b\u767a\u8868\u3055\u308c\u305f\u57fa\u790e\u7814\u7a76\u3067\u306f\uff0c\u96fb\u5b50\u30bf\u30d0\u30b3\u306e\u4f7f\u7528\u306b\u3088\u308a\uff0c<em>S. sanguinis<\/em>\u3068<em>S. gordonii<\/em>\u306e\u5897\u6b96\u304c\u59a8\u3052\u3089\u308c\u308b\u4e00\u65b9\uff0c<em>S.mutans<\/em>\u306e\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u5f62\u6210\u3092\u8457\u3057\u304f\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f<sup>35)<\/sup>\uff0e<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<h2><strong>5<\/strong><strong>\uff0e\u307e\u3068\u3081<\/strong><\/h2>\n<p>\u3000\u4eca\u56de\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u691c\u7d22\u306b\u3088\u308b\u500b\u4eba\u7684\u306a\u307e\u3068\u3081\u3067\u3059\uff0e\u3053\u308c\u304b\u3089\u7814\u7a76\u3067\u69d8\u3005\u306a\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u304f\u306e\u3060\u3068\u601d\u3044\u307e\u3059\u304c\uff0c\u305d\u3082\u305d\u3082\u55ab\u7159\u4eba\u53e3\u304c\u6e1b\u5c11\u3057\u3066\u3044\u305f\u308a\uff0c\u975e\u71c3\u713c\u5f0f\u30bf\u30d0\u30b3\u306e\u767b\u5834\uff0c\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\u7d71\u4e00\u306e\u56f0\u96e3\u3055\u306b\u3088\u3063\u3066\u5168\u3066\u304c\u660e\u3089\u304b\u306b\u306a\u308b\u306e\u306f\u6642\u9593\u304c\u304b\u304b\u308b\u306e\u304b\u306a\u3068\u611f\u3058\u307e\u3057\u305f\uff0e\u3054\u610f\u898b\u7b49\uff0c<a title=\"CONTACT\" href=\"https:\/\/yobou.work\/?page_id=70\">\u3053\u3061\u3089<\/a>\u304b\u3089\u304a\u5bc4\u305b\u3044\u305f\u3060\u3051\u307e\u3059\u3068\u52b1\u307f\u306b\u306a\u308a\u307e\u3059\uff0e<\/p>\n<p>&nbsp;<\/p>\n<p>\u3000\u30fb\u55ab\u7159\u304c\u3046\u8755\u306b\u95a2\u4e0e\u3059\u308b\u6839\u62e0\u3068\u3057\u3066\u306f<em>S.mutans<\/em>\u306e\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u3078\u306e\u5f71\u97ff\uff0csIgA\u3078\u306e\u5f71\u97ff\uff0cpH\u3078\u306e\u5f71\u97ff\u306e\uff13\u3064\u306e\u53ef\u80fd\u6027\u304c\u8003\u3048\u3089\u308c\u3066\u3044\u308b\uff0e<\/p>\n<p>\u3000\u30fb\u55ab\u7159\u306b\u3088\u3063\u3066\u53e3\u8154\u4e7e\u71e5\u304c\u8d77\u3053\u308b\u304b\u3069\u3046\u304b\u81e8\u5e8a\u7814\u7a76\u3067\u306f\u53cc\u65b9\u306e\u7d50\u679c\u304c\u51fa\u3066\u304a\u308a\uff0c\u57fa\u790e\u7814\u7a76\u3067\u3082\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u306a\u3044\uff0e<\/p>\n<p>\u3000\u30fb\u30cb\u30b3\u30c1\u30f3\u306e\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u3078\u306e\u5f71\u97ff\u4ee5\u5916\uff0c\u30bf\u30d0\u30b3\u306e\u4ed6\u306e\u6210\u5206\u304c\u3046\u8755\u306b\u95a2\u4e0e\u3059\u308b\u306e\u304b\u306a\u3069\u306f\u3088\u304f\u308f\u304b\u3063\u3066\u3044\u306a\u3044\uff0e<\/p>\n<p>\u3000\u30fb\u6709\u5bb3\u7269\u8cea\u306f\u553e\u6db2\u817a\u306b\u76f4\u63a5\u63a5\u89e6\u3057\u306a\u3044\u3053\u3068\u304b\u3089\uff0c\u3046\u8755\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u306f\u8840\u6db2\u53ef\u6eb6\u6027\u306e\u6210\u5206\u4e2d\u306b\u3042\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\uff0e<\/p>\n<p>\u3000\u30fb\u975e\u71c3\u713c\u5f0f\u30bf\u30d0\u30b3\u3082<em>S.mutans<\/em>\u306e\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u5f62\u6210\u4fc3\u9032\u306a\u3069\u304c\u5831\u544a\u3055\u308c\u3066\u304a\u308a\uff0c\u3046\u8755\u3068\u306e\u95a2\u9023\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\uff0e<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<h2><strong>6.\u00a0 \u53c2\u8003\u6587\u732e<\/strong><\/h2>\n<p>1)Chapple IL, Bouchard P, Cagetti MG, Campus G, Carra MC, Cocco F, Nibali L, Hujoel P, Laine ML, Lingstrom P, Manton DJ, Montero E, Pitts N, Rang\u00e9 H, Schlueter N, Teughels W, Twetman S, Van Loveren C, Van der Weijden F, Vieira AR, Schulte AG. Interaction of lifestyle, behaviour or systemic diseases with dental caries and periodontal diseases: consensus report of group 2 of the joint EFP\/ORCA workshop on the boundaries between caries and periodontal diseases. J Clin Periodontol. 2017 Mar;44 Suppl 18:S39-S51.<\/p>\n<p>2)Benedetti G, Campus G, Strohmenger L, Lingstr\u00f6m P. Tobacco and dental caries: a systematic review. Acta Odontol Scand. 2013 May-Jul;71(3-4):363-71.<\/p>\n<p>3)de Ara\u00fajo Nobre MA, Sezinando AM, Fernandes IC, Ara\u00fajo AC. Influence of Smoking Habits on the Prevalence of Dental Caries: A Register-Based Cohort Study. Eur J Dent. 2021 Oct;15(4):714-719.<\/p>\n<p>4)Bernab\u00e9 E, Delgado-Angulo EK, Vehkalahti MM, Aromaa A, Suominen AL. Daily smoking and 4-year caries increment in Finnish adults. Community Dent Oral Epidemiol. 2014 Oct;42(5):428-34.<\/p>\n<p>5)Huang R, Li M, Gregory RL. Effect of nicotine on growth and metabolism of Streptococcus mutans. Eur J Oral Sci. 2012 Aug;120(4):319-25.<\/p>\n<p>6)Lindemeyer RG, Baum RH, Hsu SC, Going RE. In vitro effect of tobacco on the growth of oral cariogenic streptococci. J Am Dent Assoc. 1981 Nov;103(5):719-22.<\/p>\n<p>7)Lehner T, Clarry ED, Cardwell JE. Immunoglobulins in saliva and serum in dental caries. Lancet. 1967 Jun 17;1(7503):1294-6.<\/p>\n<p>8)Golpasand Hagh L, Zakavi F, Ansarifar S, Ghasemzadeh O, Solgi G. Association of dental caries and salivary sIgA with tobacco smoking. Aust Dent J. 2013 Jun;58(2):219-23.<\/p>\n<p>9)Grover N, Sharma J, Sengupta S, Singh S, Singh N, Kaur H. Long-term effect of tobacco on unstimulated salivary pH. J Oral Maxillofac Pathol. 2016 Jan-Apr;20(1):16-9.<\/p>\n<p>10) Glass BJ, Van Dis ML, Langlais RP, Miles DA. Xerostomia: diagnosis and treatment planning considerations. Oral Surg Oral Med Oral Pathol. 1984 Aug;58(2):248-52.<\/p>\n<p>11)Rad M, Kakoie S, Niliye Brojeni F, Pourdamghan N. Effect of long-term smoking on whole-mouth salivary flow rate and oral health. J Dent Res Dent Clin Dent Prospects. 2010;4:110\u2013114.<\/p>\n<p>12)Dyasanoor S, Saddu SC. Association of xerostomia and assessment of salivary flow using modified schirmer test among smokers and healthy individuals: a preliminutesary study. J Clin Diagn Res. 2014;8:211\u2013213.<\/p>\n<p>13)Petru\u0161i\u0107 N, Posavac M, Sabol I, Mravak-Stipeti\u0107 M. The effect of tobacco smoking on salivation. Acta Stomatol Croat. 2015;49:309\u2013315.<\/p>\n<p>14)Kakoei S, Nekouei AH, Kakooei S, Najafipour H. The effect of demographic characteristics on the relationship between smoking and dry mouth in Iran: a cross-sectional, case-control study. Epidemiol Health. 2021;43:e2021017.<\/p>\n<p>15)Khan GJ, Mehmood R. Effects of long-term use of tobacco on taste receptors and salivary secretion. J Ayub Med Coll Abbottabad. 2003;15:37\u201339.<\/p>\n<p>16)Fenoll-Palomares C, Mu\u00f1oz Montagud JV, Sanchiz V, Herreros B, Hern\u00e1ndez V, M\u00ednguez M, et al. Unstimulated salivary flow rate, pH and buffer capacity of saliva in healthy volunteers. Rev Esp<\/p>\n<p>17)Smidt D, Torpet LA, Nauntofte B, Heegaard KM, Pedersen AM. Associations between labial and whole salivary flow rates, systemic diseases and medications in a sample of older people. Community Dent Oral Epidemiol. 2010 Oct;38(5):422-35.<\/p>\n<p>18)\u30bf\u30d0\u30b3\u7159\u66dd\u9732\u304c\u53ca\u307c\u3059\u30e9\u30c3\u30c8\u553e\u6db2\u30fb\u553e\u6db2\u817a\u3078\u306e\u5f71\u97ff\u3000\u677e\u672c\u6b6f\u5b66\u300035(2), 224<\/p>\n<p>19)Pangborn RM, Sharon IM. Visual deprivation and parotid response to cigarette smoking. Physiol Behav. 1971 May;6(5):559-61.<\/p>\n<p>20)Iida T, Ono K, Inagaki T, Hosokawa R, Inenaga K. Nicotinic receptor agonist-induced salivation and its cellular mechanism in parotid acini of rats. Auton Neurosci. 2011 Apr 26;161(1-2):81-6.<\/p>\n<p>21)Bernab\u00e9 E, MacRitchie H, Longbottom C, Pitts NB, Sabbah W. Birth Weight, Breastfeeding, Maternal Smoking and Caries Trajectories. J Dent Res. 2017 Feb;96(2):171-178.<\/p>\n<p>22)Leroy R, Hoppenbrouwers K, Jara A, Declerck D. Parental smoking behavior and caries experience in preschool children. Community Dent Oral Epidemiol. 2008 Jun;36(3):249-57.<\/p>\n<p>23)Aligne CA, Moss ME, Auinger P, Weitzman M. Association of pediatric dental caries with passive smoking. JAMA. 2003 Mar 12;289(10):1258-64.<\/p>\n<p>24)Tanaka K, Miyake Y, Arakawa M, Sasaki S, Ohya Y. Household smoking and dental caries in schoolchildren: the Ryukyus Child Health Study. BMC Public Health. 2010 Jun 14;10:335.<\/p>\n<p>25)Lam PPY, Chua H, Ekambaram M, Lo ECM, Yiu CKY. RISK PREDICTORS OF EARLY CHILDHOOD CARIES INCREMENT-A SYSTEMATIC REVIEW AND META-ANALYSIS. J Evid Based Dent Pract. 2022 Sep;22(3):101732.<\/p>\n<p>26)Akinkugbe AA. Does the Trimester of Smoking Matter in the Association between Prenatal Smoking and the Risk of Early Childhood Caries? Caries Res. 2021;55(2):114-121.<\/p>\n<p>27)Zhong Y, Tang Q, Tan B, Huang R. Correlation Between Maternal Smoking During Pregnancy and Dental Caries in Children: A Systematic Review and Meta-Analysis. Front Oral Health. 2021 Jun 16;2:673449.<\/p>\n<p>28)Akinkugbe AA, Brickhouse TH, Nascimento MM, Slade GD. Prenatal smoking and the risk of early childhood caries: A prospective cohort study. Prev Med Rep. 2020 Sep 22;20:101201.<\/p>\n<p>29)Hanioka T, Nakamura E, Ojima M, Tanaka K, Aoyama H. Dental caries in 3-year-old children and smoking status of parents. Paediatr Perinat Epidemiol. 2008 Nov;22(6):546-50.<\/p>\n<p>30)Williams SA, Kwan SY, Parsons S. Parental smoking practices and caries experience in pre-school children. Caries Res. 2000 Mar-Apr;34(2):117-22.<\/p>\n<p>31)Mosharrafian S, Lohoni S, Mokhtari S. Association between Dental Caries and Passive Smoking and Its Related Factors in Children Aged 3-9 Years Old. Int J Clin Pediatr Dent. 2020 Nov-Dec;13(6):600-605.<\/p>\n<p>32)\u5185\u5c71 \u8302\u4e45, \u52a0\u71b1\u5f0f\u30bf\u30d0\u30b3\uff0c\u96fb\u5b50\u30bf\u30d0\u30b3\u7b49\u975e\u71c3\u713c\u5f0f\u30bf\u30d0\u30b3\u304b\u3089\u767a\u751f\u3059\u308b\u5316\u5b66\u7269\u8cea\u306e\u5206\u6790, \u30d5\u30a1\u30eb\u30de\u30b7\u30a2, 2020, 56 \u5dfb, 8 \u53f7, p. 729-732,<\/p>\n<p>33)Irusa KF, Vence B, Donovan T. Potential oral health effects of e-cigarettes and vaping: A review and case reports. J Esthet Restor Dent. 2020 Apr;32(3):260-264.<\/p>\n<p>34)Rouabhia M, Semlali A. Electronic cigarette vapor increases Streptococcus mutans growth, adhesion, biofilm formation, and expression of the biofilm-associated genes. Oral Dis. 2021 Apr;27(3):639-647.<\/p>\n<p>35)Catala-Valentin A, Bernard JN, Caldwell M, Maxson J, Moore SD, Andl CD. E-Cigarette Aerosol Exposure Favors the Growth and Colonization of Oral Streptococcus mutans Compared to Commensal Streptococci. 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