{"id":1702,"date":"2023-05-19T12:31:50","date_gmt":"2023-05-19T03:31:50","guid":{"rendered":"https:\/\/yobou.work\/?p=1702"},"modified":"2023-08-12T17:33:36","modified_gmt":"2023-08-12T08:33:36","slug":"%e3%80%8c%e5%96%98%e6%81%af%e6%82%a3%e8%80%85%e3%81%ab%e3%81%af%e3%82%a2%e3%82%bb%e3%83%88%e3%82%a2%e3%83%9f%e3%83%8e%e3%83%95%e3%82%a7%e3%83%b3%e3%82%ab%e3%83%ad%e3%83%8a%e3%83%bc%e3%83%ab","status":"publish","type":"post","link":"https:\/\/yobou.work\/?p=1702","title":{"rendered":"\u3010\u8003\u5bdf\u3011\u300c\u5598\u606f\u60a3\u8005\u306b\u306f\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3(\u30ab\u30ed\u30ca\u30fc\u30eb\u00ae)\u304c\u5b89\u5168\u300d\u306f\u672c\u5f53\u306b\u6b63\u3057\u3044\u306e\u304b\uff1f \u2015\u6b6f\u79d1\u533b\u30fb\u53e3\u8154\u5916\u79d1\u533b\u304c\u77e5\u3063\u3066\u304a\u304f\u3079\u304d\u30a2\u30b9\u30d4\u30ea\u30f3\u5598\u606f(NSAIDs\u904e\u654f\u75c7)\u306e\u77e5\u8b58\u2015"},"content":{"rendered":"<p><img data-recalc-dims=\"1\" decoding=\"async\" class=\"aligncenter size-large wp-image-1712\" src=\"https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2023\/05\/DSCF6850.jpg?resize=665%2C499\" alt=\"\" width=\"665\" height=\"499\" srcset=\"https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2023\/05\/DSCF6850.jpg?resize=1024%2C768&amp;ssl=1 1024w, https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2023\/05\/DSCF6850.jpg?resize=300%2C225&amp;ssl=1 300w, https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2023\/05\/DSCF6850.jpg?resize=768%2C576&amp;ssl=1 768w, https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2023\/05\/DSCF6850.jpg?resize=1536%2C1152&amp;ssl=1 1536w, https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2023\/05\/DSCF6850.jpg?resize=660%2C495&amp;ssl=1 660w, https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2023\/05\/DSCF6850.jpg?w=1920&amp;ssl=1 1920w, https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2023\/05\/DSCF6850.jpg?w=1330 1330w\" sizes=\"(max-width: 665px) 100vw, 665px\" \/><\/p>\n<p>\u3000\u6b6f\u79d1\u81e8\u5e8a\u3067\u306f\u6c17\u7ba1\u652f\u5598\u606f(\u4ee5\u4e0b\u5598\u606f)\u306e\u65e2\u5f80\u3092\u6301\u3064\u60a3\u8005\u3055\u3093\u306e\u6b6f\u79d1\u6cbb\u7642\u306b\u591a\u304f\u906d\u9047\u3057\u307e\u3059\uff0e\u4e00\u822c\u6b6f\u79d1\u533b\u306b\u3082\u5598\u606f\u60a3\u8005\u3055\u3093\u306bNSAIDs\u306f(\u306a\u3093\u3068\u306a\u304f)\u5371\u967a\u3068\u3044\u3046\u8a8d\u8b58\u306f\u3042\u308a\uff0c\u591a\u304f\u306e\u6b6f\u79d1\u533b\u9662\u3067\u5598\u606f\u60a3\u8005\u306e\u629c\u6b6f\u5f8c\u7b49\u306e\u93ae\u75db\u306b\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3(\u30ab\u30ed\u30ca\u30fc\u30eb<sup>\u00ae<\/sup>)\u304c\u51e6\u65b9\u3055\u308c\u3066\u3044\u307e\u3059\uff0e<\/p>\n<p>&nbsp;<\/p>\n<p>\u3000\u5598\u606f\u306e\u4e2d\u306b\u306f\u30a2\u30e9\u30ad\u30c9\u30f3\u9178\u306e\u30b7\u30af\u30ed\u30aa\u30ad\u30b7\u30b2\u30ca\u30fc\u30bc(\u7279\u306bCOX-1)\u963b\u5bb3\u4f5c\u7528\u3092\u3082\u3064\u30a2\u30b9\u30d4\u30ea\u30f3\u306a\u3069\u306eNSAIDs\u3092\u6295\u4e0e\u3055\u308c\u308b\u3053\u3068\u306b\u3088\u308a\u5598\u606f\u767a\u4f5c\u3092\u60f9\u8d77\u3059\u308b\u3082\u306e\u304c\u3042\u308a\u307e\u3059\uff0e\u73fe\u5728\u306f\u672c\u75be\u60a3\u304c\u30a2\u30b9\u30d4\u30ea\u30f3\u4ee5\u5916\u3067\u3082\u767a\u75c7\u3059\u308b\u305f\u3081\u300cNSAIDs\u904e\u654f\u75c7(\u4e0d\u8010\u75c7)\u300d\u300c\u89e3\u71b1\u93ae\u75db\u85ac\u5598\u606f\u300d\u300cNSAIDs\u5598\u606f\u300d\u300cAsthmatic attack due to NSAIDs\u300d\u300cNSAIDs-exacerbated respiratory disease (N-ERD)\u300d\u306a\u3069\u3068\u547c\u3070\u308c\uff0c\u307b\u307c\u5168\u3066\u306eNSAIDs\u3067\u5598\u606f\u767a\u4f5c\u3092\u60f9\u8d77\u3059\u308b\u75be\u60a3\u3067\u3059\uff0e\u4eca\u56de\u306fNSAIDs\u904e\u654f\u75c7\u306b\u3064\u3044\u3066\u4e00\u822c\u7684\u306a\u5598\u606f\u3068\u306e\u9055\u3044\uff0c\u75ab\u5b66\uff0c\u4f5c\u7528\u6a5f\u5e8f\uff0c\u533b\u7642\u4e8b\u6545\u4f8b\uff0c\u5b89\u5168\u306a\u51e6\u65b9\u4f8b\u307e\u3067\u8003\u5bdf\u3057\u3066\u3044\u304d\u307e\u3059\uff0e<\/p>\n<p>&nbsp;<\/p>\n<p>\u3000\u203b\u306a\u304a\uff0c\u672c\u7a3f\u306f2023\u5e745\u6708\u6642\u70b9\u306e\u60c5\u5831\u3067\u66f8\u304b\u308c\u3066\u3044\u307e\u3059\uff0e\u81e8\u5e8a\u5fdc\u7528\u306e\u969b\u306b\u306f\u5fc5\u305a\u3054\u81ea\u8eab\u3067\u6700\u65b0\u306e\u60c5\u5831\u3092\u5f97\u3066\u3044\u305f\u3060\u304d\u307e\u3059\u3088\u3046\u304a\u9858\u3044\u7533\u3057\u4e0a\u3052\u307e\u3059\uff0e\u672c\u8a18\u4e8b\u306f\u6587\u732e\u691c\u7d22\u306b\u3088\u308b\u500b\u4eba\u306e\u898b\u89e3\u3067\u3042\u3063\u3066\uff0c\u8457\u8005\u306e\u6240\u5c5e\u7d44\u7e54\u3092\u4ee3\u8868\u3059\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u307e\u305f\uff0c\u9593\u9055\u3044\u7b49\u3042\u308a\u307e\u3057\u305f\u3089<a title=\"CONTACT\" href=\"https:\/\/yobou.work\/?page_id=70\">\u3053\u3061\u3089<\/a>\u304b\u3089\u304a\u77e5\u3089\u305b\u3044\u305f\u3060\u3051\u307e\u3059\u3068\u5e78\u3044\u3067\u3059\uff0e<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<h2><strong>\uff11\uff0eNSAIDs\u904e\u654f\u75c7\u3068\u306f<\/strong><\/h2>\n<p>&nbsp;<\/p>\n<p><strong>(1)<\/strong><strong>\u539f\u56e0<\/strong><\/p>\n<p>\u3000\u539f\u56e0\u306f\u4e0d\u660e\u3067\u3059\u304c\uff0c\u4e3b\u306bCOX-1\u963b\u5bb3\u3067\u9855\u5728\u5316\u3057\uff0c\u904e\u654f\u53cd\u5fdc\u3068\u3057\u3066\u3042\u3089\u308f\u308c\u3066\u304f\u308b\u3082\u306e\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059<sup>1)<\/sup>\uff0e\u3064\u307e\u308a\u975e\u30a2\u30ec\u30eb\u30ae\u30fc\u5b66\u7684\u6a5f\u5e8f\u3092\u6301\u3064\u75be\u60a3\u3067\u3059\uff0e\u85ac\u5264\u306e\u4ed6\u306b\u98df\u54c1\u3084\u6dfb\u52a0\u7269\uff0c\u30b9\u30c6\u30ed\u30a4\u30c9\u85ac\u3084\u8272\u7d20\u306a\u3069\u306b\u3088\u3063\u3066\u8a98\u767a\u3055\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059<sup>2)<\/sup>\uff0e\u307e\u305f\uff0c\u6b6f\u79d1\u7528\u85ac\u3067\u306f\u4e00\u90e8\u306e\u6b6f\u79d1\u5c40\u6240\u9ebb\u9154\u85ac\u306b\u542b\u307e\u308c\u308b\u9632\u8150\u5264(\u30d1\u30e9\u30d2\u30c9\u30ed\u30ad\u30b7\u5b89\u606f\u9999\u9178\u30a8\u30b9\u30c6\u30eb\uff1a\u30d1\u30e9\u30d9\u30f3)\u3082\u30c8\u30ea\u30ac\u30fc\u306b\u306a\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\uff0e<\/p>\n<p>&nbsp;<\/p>\n<p><strong>(2)<\/strong><strong>\u75ab\u5b66<\/strong><\/p>\n<p>\u3000NSAIDs\u904e\u654f\u75c7\u306f\u5c0f\u5150\u3067\u306f\u7a00\u3067\u3059\u304c\uff0c\u6210\u4eba\u306e\u5598\u606f\u306e4\uff5e28%\u306b\u307f\u3089\u308c\u308b\u3068\u8a00\u308f\u308c\uff0c\u65e5\u672c\u3067\u306f6%\u7a0b\u5ea6\u3068\u8a00\u308f\u308c\u3066\u3044\u307e\u3059<sup>2)<\/sup>\uff0eNSAIDs\u306e\u66b4\u9732\u304c\u306a\u304f\uff0c\u4e0d\u9855\u6027\u75c7\u4f8b\u3092\u542b\u3081\u308b\u3068\uff0c\u5598\u606f\u306e10%\u7a0b\u5ea6\u304cNSAIDs\u904e\u654f\u75c7\u3067\u3042\u308d\u3046\u3068\u63a8\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059<sup>2)<\/sup>\uff0e\u7537\u5973\u6bd4\u306f4:6\u3067\u3084\u3084\u5973\u6027\u306b\u591a\u304f<sup>1)<\/sup>\uff0c\u81f4\u6b7b\u7684\u5598\u606f\u767a\u4f5c\u306e\u7d044\u5206\u306e1\uff0c\u307e\u305f\u539f\u56e0\u306e\u660e\u3089\u304b\u306a\u5598\u606f\u767a\u4f5c\u6b7b\u306e40%\u304cNSAIDs\u306b\u3088\u308b\u3068\u3044\u3046\u5831\u544a\u3082\u3042\u308a\u307e\u3059<sup>3)<\/sup>\uff0e<\/p>\n<p>&nbsp;<\/p>\n<p><strong>(3)<\/strong><strong>\u75c7\u72b6<\/strong><\/p>\n<p>\u3000NSAIDs\u670d\u7528\u304b\u3089\uff0c\u901a\u5e381\u6642\u9593\u4ee5\u5185\u306b\uff0c\u9f3b\u9589\uff0c\u9f3b\u6c41\u306b\u7d9a\u304d\uff0c\u54b3\uff0c\u606f\u82e6\u3057\u3055\uff0c\u5598\u9cf4(\u305c\u3093\u3081\u3044\/\u30d2\u30e5\u30fc\u30d2\u30e5\u30fc\u3068\u3044\u3046\u547c\u5438\u97f3)\uff0c\u3068\u304d\u306b\u5614\u6c17\u3084\u8179\u75db\uff0c\u4e0b\u75e2\u306a\u3069\u306e\u8179\u90e8\u75c7\u72b6\u304c\u51fa\u73fe\u3057\u307e\u3059\uff0e\u91cd\u75c7\u4f8b\u3067\u306f\u547c\u5438\u56f0\u96e3\u306a\u3069\u91cd\u7be4\u306a\u72b6\u614b\u306b\u9665\u308a\uff0c\u6b7b\u4ea1\u4e8b\u6545\u3082\u767a\u751f\u3057\u3066\u3044\u307e\u3059\uff0e<\/p>\n<p>&nbsp;<\/p>\n<p><strong>(4)<\/strong><strong>\u8a3a\u65ad<\/strong><\/p>\n<p>\u3000\u75c5\u6b74\u304b\u3089\u8a3a\u65ad\u3067\u304d\u308b\u306e\u306f60%\u306e\u75c7\u4f8b\u3068\u8a00\u308f\u308c\u3066\u3044\u307e\u3059<sup>2)<\/sup>\u306e\u3067\uff0c\u8a3a\u65ad\u3092\u78ba\u5b9a\u3059\u308b\u305f\u3081\u306b\u306f\u8ca0\u8377\u8a66\u9a13\u304c\u5fc5\u8981\u3067\u3059.NSAIDs\u904e\u654f\u75c7\u304b\u3069\u3046\u304b\u3092\u5224\u65ad\u3059\u308b\u969b\u306b\u6709\u7528\u306a\u554f\u8a3a\u306f\u300c\uff12 NSAIDs\u904e\u654f\u75c7\u306b\u3088\u308b\u6295\u4e0e\u4e8b\u6545\u3092\u907f\u3051\u308b\u305f\u3081\u306b\u306f\u300d\u3067\u3054\u8aac\u660e\u3057\u307e\u3059\uff0e<\/p>\n<p>&nbsp;<\/p>\n<p><strong>(5)NSAIDs<\/strong><strong>\u904e\u654f\u75c7\u3092\u60f9\u8d77\u3057\u3084\u3059<\/strong><strong>\u3044NSAIDs\u4f8b<\/strong><\/p>\n<p>\u3000COX-\uff11\u963b\u5bb3\u4f5c\u7528\u306e\u5f37\u3044NSAIDs\u307b\u3069\uff0c\u904e\u654f\u75c7\u72b6\u3092\u8a98\u767a\u3057\u3084\u3059\u304f\uff0c\u304b\u3064\u8a98\u767a\u75c7\u72b6\u306f\u5f37\u5ea6\u3067\u3042\u308b<sup>2)<\/sup>\uff0e\u3068\u3055\u308c\u3066\u3044\u307e\u3059\uff0e\u4f5c\u7528\u6a5f\u5e8f\u304c\u7570\u306a\u308b\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3(\u30ab\u30ed\u30ca\u30fc\u30eb<sup>\u00ae<\/sup>)\u3084COX-2\u9078\u629e\u963b\u5bb3NSAIDs\u30bb\u30ec\u30b3\u30ad\u30b7\u30d6\u3000(\u30bb\u30ec\u30b3\u30c3\u30af\u30b9<sup>\u00ae<\/sup>)\u306f\u6bd4\u8f03\u7684\u5b89\u5168\u3068\u8a00\u308f\u308c\u3066\u3044\u307e\u3059\u304c\uff0c\u5168\u304f\u5b89\u5168\u3068\u306f\u8a00\u3048\u307e\u305b\u3093\uff0e<\/p>\n<p>\u3000\u30a2\u30b9\u30d4\u30ea\u30f3\uff08\u5e02\u8ca9\u85ac\u30d0\u30d5\u30a1\u30ea\u30f3<sup>\u00ae<\/sup>\uff09\uff0c\u30a4\u30f3\u30c9\u30e1\u30bf\u30b7\u30f3\uff08\u30a4\u30f3\u30c0\u30b7\u30f3\uff0c\u30a4\u30f3\u30c6\u30d0\u30f3<sup>\u00ae<\/sup>\uff09\uff0c\u30d4\u30ed\u30ad\u30b7\u30ab\u30e0\uff08\u30d5\u30a7\u30eb\u30c7\u30f3<sup>\u00ae<\/sup>\uff09\uff0c\u30a4\u30d6\u30d7\u30ed\u30d5\u30a7\u30f3(\u30d6\u30eb\u30d5\u30a7\u30f3\uff0c\u5e02\u8ca9\u85ac\u30a4\u30d6<sup>\u00ae<\/sup>)\uff0c\u30ca\u30d7\u30ed\u30ad\u30bb\u30f3\uff08\u30ca\u30a4\u30ad\u30b5\u30f3<sup>\u00ae<\/sup>\uff09\uff0c\u30b8\u30af\u30ed\u30d5\u30a7\u30ca\u30c3\u30af\uff08\u30dc\u30eb\u30bf\u30ec\u30f3<sup>\u00ae<\/sup>\uff09\uff0c\u30e1\u30d5\u30a7\u30ca\u30e0\u9178\uff08\u30dd\u30f3\u30bf\u30fc\u30eb<sup>\u00ae<\/sup>\uff09\uff0c\u30b9\u30eb\u30d4\u30ea\u30f3(\u30b9\u30eb\u30d4\u30ea\u30f3\u6ce8<sup>\u00ae<\/sup>)\uff0c\u30d5\u30a7\u30cb\u30eb\u30d6\u30bf\u30be\u30f3(\u30b1\u30bf\u30be\u30f3<sup>\u00ae<\/sup>)\uff0c\u30d5\u30eb\u30eb\u30d3\u30d7\u30ed\u30d5\u30a7\u30f3 \u30a2\u30ad\u30bb\u30c1\u30eb(\u30ed\u30d4\u30aa\u30f3\u6ce8<sup>\u00ae<\/sup>)\uff0c\u30ed\u30ad\u30bd\u30d7\u30ed\u30d5\u30a7\u30f3(\u30ed\u30ad\u30bd\u30cb\u30f3<sup>\u00ae<\/sup>)\u306a\u3069\u306fNSAIDs\u904e\u654f\u75c7\u3092\u60f9\u8d77\u3057\u3084\u3059\u304f\u5371\u967a\u3067\u3059\uff0e<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<h2><strong>\uff12\uff0eNSAIDs\u904e\u654f\u75c7\u306b\u3088\u308b\u6295\u4e0e\u4e8b\u6545\u3092\u907f\u3051\u308b\u305f\u3081\u306b<\/strong><\/h2>\n<p>&nbsp;<\/p>\n<p>\u3000\u75c5\u6b74\u3067\u8a3a\u65ad\u3067\u304d\u308bNSAIDs\u904e\u654f\u75c7\u306f60%\u306b\u3059\u304e\u306a\u3044<sup>2)<\/sup>\uff0e\u3068\u5831\u544a\u3055\u308c\uff0c\u901a\u5e38\u306e\u5598\u606f\u3068\u306e\u9451\u5225\u306f\u7c21\u5358\u3067\u306f\u3042\u308a\u307e\u305b\u3093\uff0e<\/p>\n<p>\u4eca\u56de\u306e\u6587\u732e\u691c\u7d22\u3067\u5f97\u3089\u308c\u305f\u5185\u5bb9\u304b\u3089\uff0c\u6b6f\u79d1\u81e8\u5e8a\u306e\u73fe\u5834\u3067\u53c2\u8003\u306b\u3067\u304d\u305d\u3046\u306a\u30dd\u30a4\u30f3\u30c8\u3092\u6319\u3052\u3066\u307f\u305f\u3044\u3068\u601d\u3044\u307e\u3059\uff0e<\/p>\n<p>\u4ee5\u4e0b\u306e\u30dd\u30a4\u30f3\u30c8\u3067\u3059\u304c\uff0c\u9650\u3089\u308c\u305f\u5185\u5bb9\u3067\u7279\u7570\u5ea6\u304c\u9ad8\u304f\u306a\u304f\uff0c\u3084\u306f\u308a\u78ba\u5b9a\u306b\u306f\u8ca0\u8377\u8a66\u9a13\u304c\u5fc5\u8981\u3067\u3042\u308b\u3053\u3068\u3092\u7533\u3057\u6dfb\u3048\u307e\u3059\uff0e<\/p>\n<p>&nbsp;<\/p>\n<p>(1)\u3000\u9f3b\u75c7\u72b6(\u55c5\u899a\u4f4e\u4e0b\u306a\u3069)\u304c\u3042\u308b\u5598\u606f\u75c7\u4f8b\u306fNSAIDs\u904e\u654f\u75c7\u306e\u53ef\u80fd\u6027\u304c\u9ad8\u3044\uff0e<\/p>\n<p>(2)\u3000\u5b63\u7bc0\u306b\u95a2\u4fc2\u306a\u304f\u5598\u606f\u75c7\u72b6\u304c\u3042\u308b\u5834\u5408(\u901a\u5e74\u6027)\u306fNSAIDs\u904e\u654f\u75c7\u306e\u53ef\u80fd\u6027\u304c\u9ad8\u3044\uff0e<\/p>\n<p>(3)\u3000\u9f3b\u708e\uff0c\u9f3b\u8338(\u30dd\u30ea\u30fc\u30d7)\uff0c\u526f\u9f3b\u8154\u708e\u306e\u5408\u4f75\uff0c\u65e2\u5f80\uff0c\u624b\u8853\u6b74\u306b\u3064\u3044\u3066\u8074\u53d6\u3059\u308b(\u5408\u4f75\u75c7\u3068\u3057\u306650\uff05\u4ee5\u4e0a\u3068\u983b\u5ea6\u304c\u9ad8\u3044)\uff0e<\/p>\n<p>(4)\u3000\u6210\u5e74\u4ee5\u964d\u306b\u767a\u75c7\u3057\u305f\u4e2d\uff5e\u91cd\u5ea6\u306e\u5598\u606f\u767a\u4f5c\u306b\u3064\u3044\u3066\u78ba\u8a8d\u3059\u308b\uff0e<\/p>\n<p>(5)\u3000\u65e2\u5f80\u6b74(\u85ac\u5264\u4f7f\u7528\u6b74)\u3092\u5c0b\u306d\uff0cNSAIDs\u3092\u670d\u7528\u3057\u305f\u3053\u3068\u304c\u3042\u308b\u304b\u3069\u3046\u304b\u3092\u78ba\u8a8d\u3059\u308b\uff0e<\/p>\n<p>\u3000\u3000\u2192\u75c5\u6b74\u4e0a\uff0cNSAIDs\u306b\u3088\u308b\u767a\u4f5c\u306e\u8a98\u767a\u6b74\u304c\u3042\u3063\u3066\u3082\uff0c\u5b9f\u969b\u306b\u306f\u305d\u306e\u3046\u306120\uff5e30%\u306fNSAIDs\u904e\u654f\u75c7\u3067\u306f\u306a\u3044\u3068\u3055\u308c\u3066\u3044\u308b<sup>4)<\/sup><\/p>\n<p>(6)\u3000\u5598\u606f\u3092\u8a3a\u5bdf\u3057\u3066\u3044\u308b\uff0c\u304b\u304b\u308a\u3064\u3051\u533b\u306b\u5bfe\u8a3a\u3059\u308b<\/p>\n<p>(7)\u3000\u9662\u5185\u51e6\u65b9\u305b\u305a\uff0c\u9662\u5916\u51e6\u65b9\u3068\u3057\u3066\u85ac\u5264\u5e2b\u3068\u306eW\u30c1\u30a7\u30c3\u30af\u4f53\u5236\u3068\u3059\u308b\uff0e<\/p>\n<p>(8)\u3000\u9ad8\u6b21\u533b\u7642\u6a5f\u95a2\u306e\u6b6f\u79d1\u30fb\u53e3\u8154\u5916\u79d1\u306a\u3069\u3078\u306e\u51e6\u7f6e\u4f9d\u983c\u3082\u691c\u8a0e\u3059\u308b\uff0e<\/p>\n<p>(9)\u3000\u3067\u304d\u308c\u3070\u9632\u8150\u5264\u3067\u3042\u308b\u30d1\u30e9\u30d9\u30f3\u3084\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u304c\u6dfb\u52a0\u3055\u308c\u3066\u3044\u306a\u3044\u5c40\u6240\u9ebb\u9154\u5264\u3092\u4f7f\u7528\u3059\u308b<sup>5)<\/sup><\/p>\n<p>&nbsp;<\/p>\n<h2><strong>\uff13\uff0eNSAIDs\u904e\u654f\u75c7\u306b\u51e6\u65b9\u53ef\u80fd\u306a\u85ac\u5264\u4f8b<\/strong><\/h2>\n<p>&nbsp;<\/p>\n<p>\u3000NSAIDs\u904e\u654f\u75c7\u3067\u306f\u306a\u3044\u901a\u5e38\u306e\u6c17\u7ba1\u652f\u5598\u606f\u3067\u3042\u308c\u3070\uff0c\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3(\u30ab\u30ed\u30ca\u30fc\u30eb<sup>\u00ae<\/sup>)\u3082\u30ed\u30ad\u30bd\u30d7\u30ed\u30d5\u30a7\u30f3\u30ca\u30c8\u30ea\u30a6\u30e0(\u30ed\u30ad\u30bd\u30cb\u30f3<sup>\u00ae<\/sup>)\u3082\u6dfb\u4ed8\u6587\u66f8\u4e0a\uff0c\u300c\u7981\u5fcc\u300d\u3067\u306f\u306a\u304f\u300c\u614e\u91cd\u6295\u4e0e\u300d\u3068\u306a\u3063\u3066\u3044\u307e\u3059\uff0e\u3057\u304b\u3057\uff0c\u4e21\u5264\u3068\u3082\u306bNSAIDs\u904e\u654f\u75c7\u60a3\u8005\u306b\u306f\u300c\u7981\u5fcc\u300d\u3068\u8a18\u8f09\u3055\u308c\u3066\u3044\u307e\u3059\uff0e<\/p>\n<p>\u3000\u6dfb\u4ed8\u6587\u66f8\u4e0a\uff0cNSAIDs\u904e\u654f\u75c7\u306b\u629c\u6b6f\u7b49\u306e\u8853\u5f8c\u75bc\u75db\u306b\u5bfe\u3057\u93ae\u75db\u5264\u3068\u3057\u3066\u4f7f\u7528\u3067\u304d\u308b\u85ac\u5264\u306f2017\u5e74\u306b\u30a8\u30e2\u30eb\u30d5\u30a1\u30be\u30f3(\u30da\u30f3\u30c8\u30a4\u30eb<sup>\u00ae<\/sup>)\u304c\u85ac\u4fa1\u53ce\u8f09\u5916(\u8ca9\u58f2\u4e2d\u6b62)\u306b\u306a\u3063\u305f\u73fe\u5728\uff0c\u30b7\u30e1\u30c8\u30ea\u30c9(\u30ad\u30e7\u30fc\u30ea\u30f3AP2)\u3068\u6f22\u65b9\u85ac(\u7acb\u52b9\u6563)\u306e\uff12\u5264\u3057\u304b\u3042\u308a\u307e\u305b\u3093\uff0e\u30a8\u30e2\u30eb\u30d5\u30a1\u30be\u30f3\u540c\u69d8\u306b\u5869\u57fa\u6027NSAIDs\u306e\u30c1\u30a2\u30e9\u30df\u30c9\u5869\u9178\u5869(\u30bd\u30e9\u30f3\u30bf\u30fc\u30eb<sup>\u00ae<\/sup>)\u3084COX-2\u9078\u629e\u963b\u5bb3NSAIDs\u306e\u30bb\u30ec\u30b3\u30ad\u30b7\u30d6(\u30bb\u30ec\u30b3\u30c3\u30af\u30b9<sup>\u00ae<\/sup>)\u3092\u85a6\u3081\u308b\u5831\u544a\u304c\u3042\u308a\u307e\u3059\u304c\uff0c\u30c1\u30a2\u30e9\u30df\u30c9\u3082\u30bb\u30ec\u30b3\u30ad\u30b7\u30d6\u3082\u6dfb\u4ed8\u6587\u66f8\u4e0a\uff0cNSAIDs\u904e\u654f\u75c7\u60a3\u8005\u3078\u306e\u6295\u4e0e\u306f\u7981\u5fcc\u306b\u306a\u3063\u3066\u3044\u307e\u3059<sup>6)7)<\/sup>\uff0e<\/p>\n<p>\u3000\u6587\u732e\u306b\u3088\u3063\u3066\u306f\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3\u306a\u3069\u767a\u4f5c\u8a98\u767a\u6027\u306e\u4f4e\u3044\u85ac\u5264\u3092\u4f4e\u7528\u91cf(1\u56de300mg\u4ee5\u4e0b)\u3067\u4f7f\u7528\u3059\u308b(1\u56de500mg\u4ee5\u4e0a\u306b\u306a\u308b\u30681\/3\u306e\u75c7\u4f8b\u306b\u767a\u4f5c\u3092\u8a98\u767a\u3059\u308b)<sup>2)<\/sup>\u3053\u3068\u3082\u6709\u52b9\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u304c\uff0c1\u56de300mg\u4ee5\u4e0b\u3068\u3044\u3046\u306e\u306f\u975e\u5e38\u306b\u5c11\u306a\u3044\u91cf\u3067\uff0c30kg\u306e\u5c0f\u5150\u306b\u5bfe\u3059\u308b\u6295\u4e0e\u91cf\u3068\u540c\u7b49\u3067\u3059\uff0e<\/p>\n<p><img data-recalc-dims=\"1\" decoding=\"async\" class=\"aligncenter size-full wp-image-1707\" src=\"https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2023\/05\/NSAIDs%E3%81%BE%E3%81%A8%E3%82%81.jpg?resize=665%2C349\" alt=\"\" width=\"665\" height=\"349\" srcset=\"https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2023\/05\/NSAIDs%E3%81%BE%E3%81%A8%E3%82%81.jpg?w=881&amp;ssl=1 881w, https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2023\/05\/NSAIDs%E3%81%BE%E3%81%A8%E3%82%81.jpg?resize=300%2C157&amp;ssl=1 300w, https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2023\/05\/NSAIDs%E3%81%BE%E3%81%A8%E3%82%81.jpg?resize=768%2C403&amp;ssl=1 768w, https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2023\/05\/NSAIDs%E3%81%BE%E3%81%A8%E3%82%81.jpg?resize=660%2C346&amp;ssl=1 660w, https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2023\/05\/NSAIDs%E3%81%BE%E3%81%A8%E3%82%81.jpg?resize=380%2C200&amp;ssl=1 380w\" sizes=\"(max-width: 665px) 100vw, 665px\" \/><\/p>\n<p style=\"text-align: center;\">fig.1 NSAIDs\u904e\u654f\u75c7\u306b\u5bfe\u3059\u308b(\u6b6f\u79d1\u9069\u5fdc)\u93ae\u75db\u85ac\u306e\u307e\u3068\u3081<br \/>\n\u203b\u6587\u732e\u691c\u7d22\u306b\u3088\u308b\u5f53Blog\u306e\u307e\u3068\u3081\u3067\u3059\uff0e\u81e8\u5e8a\u5fdc\u7528\u306e\u969b\u306f\u3054\u81ea\u8eab\u3067\u3054\u5224\u65ad\u304f\u3060\u3055\u3044\uff0e<\/p>\n<p>&nbsp;<\/p>\n<h2><strong>\uff14\uff0eNSAIDs\u904e\u654f\u75c7\u306e\u767a\u4f5c\u304c\u751f\u3058\u3066\u3057\u307e\u3063\u305f\u3089<\/strong><\/h2>\n<p>&nbsp;<\/p>\n<p>\u3000NSAIDS\u306e\u670d\u7528\u5f8c\u306e\u5598\u606f\u767a\u4f5c(\u54b3\uff0c\u547c\u5438\u82e6\uff0c\u5598\u9cf4\u306a\u3069)\u3068\u9f3b\u75c7\u72b6(\u9f3b\u9589\uff0c\u9f3b\u6c41)\u306e\u767a\u73fe\u306fNSAIDs\u904e\u654f\u75c7\u306e\u767a\u4f5c\u3092\u5f37\u304f\u7591\u3046\u3079\u304d\u3067\u3059\uff0e\u7d4c\u9a13\u7684\u306b\uff0cNSAIDs\u904e\u654f\u75c7\u306b\u9650\u3089\u305a\uff0c\u4f1a\u8a71\u304c\u3067\u304d\u306a\u3044\u3088\u3046\u306a\u4e2d\u7b49\u5ea6\u4ee5\u4e0a\u306e\u5598\u606f\u767a\u4f5c\u306e\u5834\u5408\uff0c\u6b6f\u79d1\u533b\u9662\u3068\u3044\u3046\u9650\u3089\u308c\u305f\u65bd\u8a2d\u3067\u306f\u5bfe\u5fdc\u304c\u56f0\u96e3\u306a\u305f\u3081\uff0c\u3059\u3050\u306b\u6551\u6025\u533b\u7642\u6a5f\u95a2\u306b\u642c\u9001\u3059\u308b\u3079\u304d\u3068\u8003\u3048\u3066\u3044\u307e\u3059\uff0e<\/p>\n<p>\u3000\u6551\u6025\u8eca\u304c\u304f\u308b\u307e\u3067\u6b6f\u79d1\u533b\u9662\u3067\u5bfe\u5fdc\u3067\u304d\u308b\u3053\u3068\u306f\u9178\u7d20\u6295\u4e0e\u3092\u5b9f\u65bd\u3057\uff0cSpo2\u3092\u30e2\u30cb\u30bf\u30fc\u3057\u307e\u3059\uff0e\u60a3\u8005\u3092\u5ea7\u4f4d\u306b\u3057\u53ef\u80fd\u3067\u3042\u308c\u3070\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u30920.1\uff5e0.3ml\/\u56de\u3092\u7b4b\u6ce8\u3057\u307e\u3059\uff0e\u30eb\u30fc\u30c8\u304c\u53d6\u308c\u308c\u3070\u30eb\u30fc\u30c8\u3092\u53d6\u3063\u3066\u304a\u304d\u307e\u3059\uff0e\u30b9\u30c6\u30ed\u30a4\u30c9\u3092\u70b9\u6ef4\u9759\u6ce8\u3059\u308b\u5834\u5408\uff0c\u901a\u5e38\u306e\u5598\u606f\u767a\u4f5c\u306b\u983b\u7528\u3055\u308c\u308b\u30b5\u30af\u30b7\u30be\u30f3<sup>\u00ae<\/sup>\uff0c\u30bd\u30eb\u30fb\u30b3\u30fc\u30c6\u30d5<sup>\u00ae<\/sup>\uff0c\u30bd\u30eb\u30fb\u30e1\u30c9\u30ed\u30fc\u30eb<sup>\u00ae<\/sup>\u306a\u3069\u306e\u30b3\u30cf\u30af\u9178\u30a8\u30b9\u30c6\u30eb\u30b9\u30c6\u30ed\u30a4\u30c9\u306f\u7981\u5fcc\u3067\u3059\uff0e\u30c7\u30ab\u30c9\u30ed\u30f3<sup>\u00ae<\/sup>\uff0c\u30ea\u30f3\u30c7\u30ed\u30f3<sup>\u00ae<\/sup>\u306a\u3069\u30ea\u30f3\u9178\u30a8\u30b9\u30c6\u30eb\u30b9\u30c6\u30ed\u30a4\u30c9\u30921\uff5e2\u6642\u9593\u4ee5\u4e0a\u304b\u3051\u3066\u3086\u3063\u304f\u308a\u70b9\u6ef4\u9759\u6ce8\u3057\u307e\u3059\uff0e\u6025\u901f\u306a\u9759\u8108\u6ce8\u5c04\u306f\u5371\u967a\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059<sup>3)<\/sup>\uff0e<\/p>\n<p>&nbsp;<\/p>\n<h2><strong>\uff15\uff0eNSAIDs\u904e\u654f\u75c7\u60a3\u8005\u306e\u533b\u7642\u4e8b\u6545\u3000\u2015\u95a2\u9023\u3059\u308b\uff13\u3064\u306e\u5224\u4f8b\u2015<\/strong><\/h2>\n<p>&nbsp;<\/p>\n<p><strong>\u4e8b\u6545\u75c7\u4f8b\uff11\u300c\u8033\u9f3b\u79d1\u533b\u304cNSAIDs\u904e\u654f\u75c7\u60a3\u8005\u306b\u30dc\u30eb\u30bf\u30ec\u30f3\u3092\u51e6\u65b9\u3057\u60a3\u8005\u304c\u6b7b\u4ea1\u3057\u305f\u30b1\u30fc\u30b9\u300d<\/strong>\u5e83\u5cf6\u9ad8\u88c1\u3000\u5e73\u62104\u5e743\u670826\u65e5\u5224\u6c7a<\/p>\n<p>\u3000\u30ab\u30eb\u30c6\u306b\u306f\u300c\u30d4\u30ea\u30f3\u7981\u300d\u3068\u306f\u8a18\u8f09\u3057\u3066\u3042\u3063\u305f\u304c\uff0c\u85ac\u306b\u3088\u308b\u5598\u606f\u767a\u4f5c\u306e\u65e2\u5f80\u6b74\u306a\u3057\u3068\u306e\u8a18\u8f09\u304c\u3042\u3063\u305f\u305f\u3081\uff0c\u62c5\u5f53\u533b\u3068\u306f\u5225\u306e\u533b\u5e2b\u304c\u9f3b\u8338\u9664\u53bb\u624b\u8853\u306e\u8853\u5f8c\u75bc\u75db\u306b\u30dc\u30eb\u30bf\u30ec\u30f3\uff12\u9320\u3092\u51e6\u65b9\u3057\u305f\uff0eNSAIDs\u904e\u654f\u75c7\u3068\u306f\u65ad\u5b9a\u3067\u304d\u306a\u3044\u304c\uff0c\u7591\u3044\u304c\u3042\u3063\u305f\u60a3\u8005\u306b\u5bfe\u3057\u8ca0\u8377\u8a66\u9a13\u306a\u304fNSAIDs(\u30dc\u30eb\u30bf\u30ec\u30f3\uff12\u9320)\u3092\u51e6\u65b9\u3057\u305f\u904e\u5931\u304c\u8a8d\u3081\u3089\u308c\u7d043,500\u4e07\u5186\u306e\u640d\u5bb3\u8ce0\u511f\u3092\u8a8d\u3081\u305f\uff0e<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u4e8b\u6545\u75c7\u4f8b\uff12\u300c\u6b6f\u79d1\u533b\u304c\u667a\u6b6f\u629c\u6b6f\u5f8c\uff0cNSAIDs\u904e\u654f\u75c7\u60a3\u8005\u306b\u30ed\u30ad\u30bd\u30cb\u30f3\u3092\u51e6\u65b9\u3057\uff0c\u6b7b\u4ea1\u3057\u305f\u30b1\u30fc\u30b9\u300d<\/strong>\u798f\u5ca1\u5730\u88c1\u3000\u5e73\u62106\u5e7412\u670826\u65e5\u5224\u6c7a<\/p>\n<p>\u3000\u5e73\u6210\uff12\u5e74\uff13\u6708\uff0c\u798f\u5ca1\u770c\u5185\u306e\u6b6f\u79d1\u533b\u9662\u3067\u667a\u6b6f\u629c\u6b6f\u304c\u5b9f\u65bd\u3055\u308c\uff0c\u629c\u6b6f\u5f8c\u306b\u30ed\u30ad\u30bd\u30cb\u30f3\uff0c\u30ec\u30d5\u30c8\u30fc\u30bc\uff0c\u30b1\u30d5\u30ec\u30c3\u30af\u30b9\u304c\u51e6\u65b9\u3055\u308c\u305f\uff0e\u60a3\u8005\u306f\u81ea\u5b85\u306b\u623b\u308a\u5348\u5f8c3\u6642\u534a\u9803\u306b\u5598\u606f\u306e\u767a\u4f5c\u3092\u8d77\u3053\u3057\uff12\u56de\u5438\u5165\u5264\u306e\u5438\u5165\u3092\u8a66\u307f\u305f\uff0e\u3057\u304b\u3057\u767a\u4f5c\u304c\u53ce\u307e\u3089\u305a\u610f\u8b58\u3092\u5931\u3063\u305f\uff0e\u5f80\u8a3a\u3057\u305f\u547c\u5438\u5668\u79d1\u533b\u5e2b\u306b\u3088\u308a\u8607\u751f\u63aa\u7f6e\u304c\u8a66\u307f\u3089\u308c\u305f\u304c\u540c\u65e55\u6642\u534a\uff0c\u60a3\u8005\u306f\u6b7b\u4ea1\u3068\u8a3a\u65ad\u3055\u308c\u305f\uff0e\u6b6f\u79d1\u4e88\u8a3a\u7968\u306e\u65e2\u5f80\u6b74\u306b\u5598\u606f\u3068\u8a18\u8f09\u3055\u308c\uff0c\u6b6f\u79d1\u533b\u5e2b\u306b\u3088\u308b\u554f\u8a3a\u3067\u3082\u5598\u606f\u3068\u30d4\u30ea\u30f3\u7cfb\u306e\u85ac\u5264\u3067\u5598\u606f\u306e\u767a\u4f5c\u304c\u8d77\u3053\u308b\u65e8\u3092\u7b54\u3048\u3066\u3044\u305f\uff0e\u88c1\u5224\u306b\u304a\u3044\u3066\u6b6f\u79d1\u533b\u5e2b\u5074\u306f\u6b6f\u79d1\u754c\u3067NSAIDs\u904e\u654f\u75c7\u306f\u77e5\u3089\u308c\u3066\u3044\u306a\u304b\u3063\u305f\u306a\u3069\u3068\u4e3b\u5f35\u3057\u305f\u304c\uff0c\u7814\u947d\u7fa9\u52d9\u3092\u6020\u3063\u305f\u306a\u3069\u6b6f\u79d1\u533b\u5e2b\u306e\u4e0d\u6cd5\u884c\u70ba\u8cac\u4efb\u304c\u8a8d\u3081\u3089\u308c\u7d042,000\u4e07\u5186\u306e\u640d\u5bb3\u8ce0\u511f\u3092\u8a8d\u3081\u305f\uff0e<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u4e8b\u6545\u75c7\u4f8b\uff13\u300c\u4f11\u65e5\u8a3a\u7642\u6240\u3067\u30ed\u30ad\u30bd\u30cb\u30f3\u3092\u51e6\u65b9\u3055\u308c\uff0c\u6b7b\u4ea1\u3057\u305f\u30b1\u30fc\u30b9\u300d<\/strong>\u524d\u6a4b\u5730\u88c1\u3000\u5e73\u621024\u5e748\u670831\u65e5\u5224\u6c7a<\/p>\n<p>\u3000\u5e73\u621022\u5e74\uff0c\u5f53\u664253\u6b73\u306e\u7537\u6027\u304c\u7fa4\u99ac\u770c\u5185\u306e\u6b6f\u79d1\u533b\u5e2b\u4f1a\u7acb\u4f11\u65e5\u8a3a\u7642\u6240\u3067\u6b6f\u306e\u6cbb\u7642\u3092\u53d7\u3051\u305f\u5f8c\uff0c\u51e6\u65b9\u3055\u308c\u305f\u30ed\u30ad\u30bd\u30cb\u30f3\u306a\u3069\u3092\u670d\u7528\u3057\u305f\uff0e\u9593\u3082\u306a\u304f\u5fc3\u80ba\u505c\u6b62\u72b6\u614b\u306b\u306a\u308a21\u65e5\u5f8c\u306b\u6b7b\u4ea1\u3057\u305f\uff0e\u88c1\u5224\u6240\u306f\u4eca\u307e\u3067\u7d4c\u904e\u89b3\u5bdf\u3057\u3066\u3044\u305f\u533b\u5e2b\u3078\u306e\u60c5\u5831\u63d0\u4f9b\u3092\u6c42\u3081\u308b\u3079\u304d\u3060\u3063\u305f\uff0c\u60a3\u8005\u306b\u5371\u967a\u6027\u3068\u5fc5\u8981\u6027\u3092\u8aac\u660e\u3057\u3066\u81ea\u899a\u75c7\u72b6\u3092\u5831\u544a\u3055\u305b\u308b\u3079\u304d\u3060\u3063\u305f\uff0c\u6295\u4e0e\u91cf\u306e\u6f38\u5897\u3055\u305b\u308b\u65b9\u6cd5\u3092\u3068\u308b\u3079\u304d\u3060\u3063\u305f\uff0c\u6551\u6025\u6551\u547d\u5177\u306e\u70b9\u691c\u4e0d\u5341\u5206\u3084\u8d77\u5ea7\u547c\u5438\u306e\u6bb5\u968e\u3067\u5598\u606f\u767a\u4f5c\u3068\u8a3a\u65ad\u3067\u304d\u306a\u304b\u3063\u305f\u306e\u306f\u30df\u30b9\u3067\u3042\u308b\u3068\u3057\u305f\uff0e\u3057\u304b\u3057\uff0c\u7537\u6027\u306f\u305d\u308c\u307e\u3067NSAIDs\u904e\u654f\u75c7\u3068\u8a3a\u65ad\u3055\u308c\u305f\u3053\u3068\u304c\u306a\u304b\u3063\u305f(\u554f\u8a3a\u7968\u65e2\u5f80\u6b74\u6b04\u306b\u5598\u606f\u3068\u306f\u8a18\u8f09\u3057\u3066\u3044\u305f)\uff0e\u307e\u305f\uff0c\u4ee5\u524d\uff0c\u975e\u30b9\u30c6\u30ed\u30a4\u30c9\u6027\u6297\u708e\u75c7\u85ac\u3092\u51e6\u65b9\u3055\u308c\u670d\u7528\u3057\u305f\u3068\u601d\u308f\u308c\u308b\u304c\u7570\u5e38\u306f\u306a\u304b\u3063\u305f\u3053\u3068\u304b\u3089\uff0c\u30ed\u30ad\u30bd\u30cb\u30f3\u6295\u4e0e\u306b\u3088\u3063\u3066\u91cd\u3044\u767a\u4f5c\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u306f\u4e88\u898b\u3067\u304d\u306a\u304b\u3063\u305f\u3068\u3057\u3066\uff0c\u62c5\u5f53\u533b\u5e2b\u306e\u904e\u5931\u3092\u8a8d\u3081\u305a\uff0c\u7537\u6027\u306e\u6b7b\u4ea1\u3068\u306e\u56e0\u679c\u95a2\u4fc2\u3082\u8a8d\u3081\u3089\u308c\u306a\u3044\u3068\u5224\u65ad\u3057\u539f\u544a\u306e\u8a34\u3048\u306f\u68c4\u5374\u3055\u308c\u305f\uff0e<\/p>\n<p>&nbsp;<\/p>\n<h2><strong>\uff16\uff0eQ&amp;A(\u3088\u304f\u3042\u308b\u8cea\u554f\u96c6)<\/strong><\/h2>\n<p>&nbsp;<\/p>\n<p><strong>Q1\u00a0<\/strong> <strong>NSAIDs<\/strong><strong>\u904e\u654f\u75c7\u306f\u907a\u4f1d\u3057\u307e\u3059\u304b\uff1f<\/strong><\/p>\n<p>\u3000A \u5bb6\u65cf\u5185\u767a\u75c7\u306f\u7a00\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059<sup>1)<\/sup>\uff0e<\/p>\n<p><strong>Q2\u00a0 NSAIDs<\/strong><strong>\u30a2\u30ec\u30eb\u30ae\u30fc\u3068\u306e\u9451\u5225\u306f\uff1f<\/strong><\/p>\n<p>\u3000A NSAIDs\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u5834\u5408\u306f\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u75c7\u72b6\u3084\u76ae\u75b9\u304c\u767a\u75c7\u3057\u307e\u3059\u304c\uff0c\u9451\u5225\u306f\u56f0\u96e3\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059<sup>1)<\/sup>\uff0e<\/p>\n<p><strong>Q3 <\/strong><strong>\u6e7f\u5e03\u85ac\u3067\u3082\u767a\u75c7\u3057\u307e\u3059\u304b\uff1f<\/strong><\/p>\n<p>\u3000A\u30b8\u30af\u30ed\u30d5\u30a7\u30ca\u30af\u30ca\u30c8\u30ea\u30a6\u30e0\u3084\u30ed\u30ad\u30bd\u30d7\u30ed\u30d5\u30a7\u30f3\u30ca\u30c8\u30ea\u30a6\u30e0\u304c\u914d\u5408\u3055\u308c\u305f\u6e7f\u5e03\u85ac\u3067\u3082NSAIDs\u904e\u654f\u75c7\u306f\u767a\u75c7\u3057\u307e\u3059\uff0e\u7d4c\u76ae\u3067\u306e\u5438\u53ce\u306f\u7d4c\u53e3\u306e100\u5206\u306e1\u7a0b\u5ea6\u3067\u3059\u304c\uff0c\u307e\u3063\u305f\u304f\u5b89\u5168\u306a\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093<sup>3)<\/sup>\uff0e<\/p>\n<p><strong>Q4 <\/strong><strong>\u3069\u3046\u8a3a\u65ad\u3055\u308c\u307e\u3059\u304b\uff1f<\/strong><\/p>\n<p>\u3000A\u660e\u3089\u304b\u306a\u8a98\u767a\u6b74\u2460\u539f\u56e0NSAIDs\u670d\u7528\u304b\u3089\uff11\u6642\u9593\u4ee5\u5185\u306e\u767a\u4f5c\u51fa\u73fe\uff0c\u2461\u4e2d\u767a\u4f5c\u4ee5\u4e0a(\u8d77\u5ea7\u547c\u5438\u3092\u4f34\u3046\u767a\u4f5c)\uff0c\u2462\u9f3b\u9589\uff0c\u9f3b\u6c41\u306a\u3069\u306e\u9f3b\u75c7\u72b6\u3092\u4f34\u3046<br \/>\n\u3000\u3000\u3053\u306e\uff13\u3064\u306e\u660e\u3089\u304b\u306a\u8a98\u767a\u6b74\u304c\u3042\u308a\uff0c\u9f3b\u8338\u3092\u5408\u4f75\u3057\u305f\u5598\u606f\u306f\u8ca0\u8377\u8a66\u9a13\u3092\u305b\u305a\u306b\u672c\u75c7\u3068\u8a3a\u65ad\u3057\u307e\u3059<sup>8)<\/sup>\uff0e\u8981\u4ef6\u3092\u6e80\u305f\u3055\u306a\u3044\u5834\u5408\u306f\u8ca0\u8377\u8a66\u9a13\u3092\u5b9f\u65bd\u3057\u307e\u3059<\/p>\n<p><strong>Q5 <\/strong><strong>\u78ba\u5b9a\u8a3a\u65ad\u306b\u5fc5\u8981\u306a\u8ca0\u8377\u8a66\u9a13\u306f\u3069\u306e\u3088\u3046\u306a\u3082\u306e\u3067\u3059\u304b\uff1f <\/strong><\/p>\n<p>\u3000A\u6c17\u7ba1\u652f\u5438\u5165\uff0c\u9f3b\u5438\u5165\uff0c\u9759\u6ce8\uff0c\u5185\u670d\u306b\u3088\u308b\u8a66\u9a13\u304c\u3042\u308a\u307e\u3059<sup>8) <\/sup><\/p>\n<p><strong>Q6 <\/strong><strong>\u8ca0\u8377\u8a66\u9a13\u306f\u6b6f\u79d1\u533b\u9662\u3067\u3082\u53ef\u80fd\u3067\u3059\u304b\uff1f<\/strong><\/p>\n<p>\u3000A\u8ca0\u8377\u8a66\u9a13\u306f\u4f8b\u3048\u5fae\u91cf\u3067\u3042\u3063\u3066\u3082\u5371\u967a\u3092\u4f34\u3044\u307e\u3059\uff0e\u6b6f\u79d1\u533b\u9662\u3067\u306f\u7d76\u5bfe\u306b\u884c\u3063\u3066\u306f\u3044\u3051\u307e\u305b\u3093\uff0e<\/p>\n<p>&nbsp;<\/p>\n<h2><strong>\uff17\uff0e\u307e\u3068\u3081<\/strong><\/h2>\n<p>\u30fb\u5598\u606f\u60a3\u8005\u306e6\uff5e10%\u7a0b\u5ea6\u304cNSAIDs\u904e\u654f\u75c7(\u30a2\u30b9\u30d4\u30ea\u30f3\u5598\u606f)\u3067\u3042\u308b<sup>2)<\/sup>\uff0e<\/p>\n<p>\u30fb\u5598\u606f\u304bNSAIDs\u904e\u654f\u75c7\u304b\u5224\u65ad\u3067\u304d\u306a\u3044\u5834\u5408\u306b\u306f\u3068\u308a\u3042\u3048\u305aNSAIDs\u904e\u654f\u75c7\u3068\u3057\u3066\u6271\u3046\u3053\u3068\u304c\u59a5\u5f53<sup>1)<\/sup>\uff0e<\/p>\n<p>\u30fb\u5598\u606f\u304bNSAIDs\u904e\u654f\u75c7\u304b\u5224\u65ad\u3067\u304d\u306a\u3044\u5834\u5408\u306b\u306f\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3\u30921\u56de300mg\u4ee5\u4e0b\u3067\u4f7f\u7528\u3059\u308b(\u8a98\u767a\u306e\u5371\u967a\u6027\u304c\u306a\u3044\u3068\u306f\u8a00\u3048\u306a\u3044\u3057\uff0c\u93ae\u75db\u52b9\u679c\u304c\u5f31\u3044)\uff0e<\/p>\n<p>\u30fbNSAIDs\u904e\u654f\u75c7\u60a3\u8005\u306b\u5bfe\u3059\u308b\u6b6f\u79d1\u9069\u5fdc\u85ac\u306f\u73fe\u5728\uff0c\u30b7\u30e1\u30c8\u30ea\u30c9(\u30ad\u30e7\u30fc\u30ea\u30f3AP2)\u3068\u6f22\u65b9\u85ac(\u7acb\u52b9\u6563)\u306e\uff12\u5264\u306e\u307f\uff0e<\/p>\n<p>\u30fbNSAIDs\u904e\u654f\u75c7\u60a3\u8005\u306e\u629c\u6b6f\u306a\u3069\u306e\u53e3\u8154\u5916\u79d1\u624b\u8853\u306f\u5bfe\u5fdc\u53ef\u80fd\u306a\u9ad8\u6b21\u533b\u7642\u6a5f\u95a2\u3078\u5bfe\u8a3a\u3059\u308b\u3053\u3068\u3082\u691c\u8a0e\u3059\u308b\uff0e<\/p>\n<p>\u30fbNSAIDs\u904e\u654f\u75c7\u306b\u9650\u3089\u305a\u5598\u606f\u60a3\u8005\u306f\u30b9\u30c6\u30ed\u30a4\u30c9\u3092\u9577\u671f\u9593\u670d\u7528\u3057\u3066\u3044\u308b\u3053\u3068\u3082\u591a\u304f\uff0c\u611f\u67d3\u306b\u5bfe\u3059\u308b\u914d\u616e\u3082\u5fc5\u8981\uff0e<\/p>\n<p>\u30fb\u30c8\u30ea\u30ac\u30fc\u3068\u306a\u308b\u6b6f\u79d1\u6cbb\u7642\u306b\u3088\u308b\u30b9\u30c8\u30ec\u30b9\u3084\u6b6f\u79d1\u85ac\u54c1\u306b\u3088\u308b\u30ec\u30b8\u30f3\u30e2\u30ce\u30de\u30fc<sup>5)<\/sup>\u3084\u30df\u30f3\u30c8\u9999\u5473<sup>9)<\/sup>\u306a\u3069\u306e\u81ed\u3044\u306b\u3082\u914d\u616e\u3059\u308b\uff0e<\/p>\n<p>&nbsp;<\/p>\n<h2><strong>8<\/strong><strong>\uff0e\u53c2\u8003\u6587\u732e<\/strong><\/h2>\n<p>1)\u00a0 \u539a\u751f\u52b4\u50cd\u7701\u3000\u91cd\u7be4\u526f\u4f5c\u7528\u75be\u60a3\u5225\u5bfe\u5fdc\u30de\u30cb\u30e5\u30a2\u30eb\u00a0 \u975e\u30b9\u30c6\u30ed\u30a4\u30c9\u6027\u6297\u708e\u75c7\u85ac\u306b\u3088\u308b\u5598\u606f\u767a\u4f5c<\/p>\n<p>2) \u698a\u539f \u535a\u6a39 NSAIDs\u904e\u654f\u75c7\u3000\u65e5\u672c\u5185\u79d1\u5b66\u4f1a\u96d1\u8a8c\/85 \u5dfb (1996) 2 \u53f7<\/p>\n<p>3) \u9577\u5742\u884c\u96c4\u3000\u5185\u79d1\u3088\u308a\uff0dNSAIDs\u904e\u654f\u75c7\u3092\u4e2d\u5fc3\u306b\u3000\u65e5\u6c17\u98df\u4f1a\u5831,48 (2),1997 147-148<\/p>\n<p>4)\u00a0 Spector SL, Wangaard CH, Farr RS. Aspirin and concomitant idiosyncrasies in adult asthmatic patients. J Allergy Clin Immunol. 1979 Dec;64(6 Pt 1):500-6.<\/p>\n<p>5) \u5f8c\u85e4\u9686\u5fd7\uff0c\u4e00\u6238\u9054\u4e5f\u3000\u6c17\u7ba1\u652f\u5598\u606f\u3092\u6709\u3059\u308b\u60a3\u8005\u306b\u5bfe\u3059\u308b\u6b6f\u79d1\u6cbb\u7642\u6642\u306e\u6ce8\u610f\u70b9\u3092\u6559\u3048\u3066\u304f\u3060\u3055\u3044\uff0e\u6b6f\u79d1\u5b66\u5831\u3000Vol. 112, No.4(2012)<\/p>\n<p>6) \u30c1\u30a2\u30e9\u30df\u30c9\u5869\u9178\u5869\u3000\u30bd\u30e9\u30f3\u30bf\u30fc\u30eb<sup>\u00ae<\/sup>\u3000\u6dfb\u4ed8\u6587\u66f8\u3000LTL\u30d5\u30a1\u30fc\u30de\u682a\u5f0f\u4f1a\u793e2021\u5e748\u6708\u6539\u8a02\uff08\u7b2c1\u7248\uff09<\/p>\n<p>7) \u30bb\u30ec\u30b3\u30c3\u30af\u30b9\u9320\u3000\u6dfb\u4ed8\u6587\u66f8\u3000\u30f4\u30a3\u30a2\u30c8\u30ea\u30b9\u88fd\u85ac\u682a\u5f0f\u4f1a\u793e\u30002022\u5e7412\u6708\u6539\u8a02\uff08\u7b2c3\u7248\uff09<\/p>\n<p>8) \u8c37\u53e3 \u6b63\u5b9f\u3000\u6c17\u9053\u904e\u654f\u6027\u691c\u67fb\u3068\u30a2\u30b9\u30d4\u30ea\u30f3\u8ca0\u8377\u8a66\u9a13\u306e\u5b9f\u969b(\u30a2\u30ec\u30eb\u30ae\u30fc\u5b9f\u8df5\u8b1b\u5ea7)\u3000 \u30a2\u30ec\u30eb\u30ae\u30fc\/58 \u5dfb (2009) 2 \u53f7<\/p>\n<p>9) \u8c37\u53e3 \u6b63\u5b9f\u3000NSAIDs\u4e0d\u8010\u75c7\/\u30a2\u30b9\u30d4\u30ea\u30f3\u5598\u606f\uff08AERD\uff09\u306b\u304a\u3051\u308b\u75c5\u614b\u89e3\u660e\u306e\u9032\u6b69\u3068\u81e8\u5e8a\u7684\u5074\u9762 IRYO\u3000Vol\uff0e74\u3000No. 10\uff08428\uff0d436\uff092020<\/p>\n<p>&nbsp;<\/p>\n<h2>\uff19\uff0e\u304a\u3059\u3059\u3081<\/h2>\n<p>&nbsp;<\/p>\n<p><!-- START MoshimoAffiliateEasyLink --><\/p>\n<p><script 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id=\"msmaflink-F06W0\">\u30ea\u30f3\u30af<\/div>\n<p><!-- MoshimoAffiliateEasyLink END --><\/p>\n<p>\u6c17\u7ba1\u652f\u5598\u606f\u306b\u3064\u3044\u3066\u6df1\u304f\u5b66\u3073\u305f\u3044\u65b9\u306f\u3053\u3061\u3089\u3092<\/p>\n<p>&nbsp;<\/p>\n<p><!-- START MoshimoAffiliateEasyLink --><\/p>\n<p><script type=\"text\/javascript\">(function(b,c,f,g,a,d,e){b.MoshimoAffiliateObject=a;b[a]=b[a]||function(){arguments.currentScript=c.currentScript||c.scripts[c.scripts.length-2];(b[a].q=b[a].q||[]).push(arguments)};c.getElementById(a)||(d=c.createElement(f),d.src=g,d.id=a,e=c.getElementsByTagName(\"body\")[0],e.appendChild(d))})(window,document,\"script\",\"\/\/dn.msmstatic.com\/site\/cardlink\/bundle.js?20220329\",\"msmaflink\");msmaflink({\"n\":\"\u6b6f\u79d1\u885b\u751f\u58eb\u306e\u305f\u3081\u306e 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