{"id":377,"date":"2021-02-19T13:30:21","date_gmt":"2021-02-19T04:30:21","guid":{"rendered":"http:\/\/yobou.work\/?p=377"},"modified":"2023-01-23T12:27:00","modified_gmt":"2023-01-23T03:27:00","slug":"%e6%ad%af%e7%a7%91%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e3%83%90%e3%82%a4%e3%82%aa%e3%83%95%e3%82%a3%e3%83%ab%e3%83%a0%e6%84%9f%e6%9f%93%e7%97%87","status":"publish","type":"post","link":"https:\/\/yobou.work\/?p=377","title":{"rendered":"\u3010\u8003\u5bdf\u3011\u53e3\u8154\u9818\u57df\u306e\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u611f\u67d3\u75c7\u306b\u3064\u3044\u3066\u8003\u3048\u3066\u307f\u305f\u3002"},"content":{"rendered":"<p><img data-recalc-dims=\"1\" decoding=\"async\" class=\"aligncenter size-large wp-image-382\" src=\"https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2021\/02\/P1010881.jpg?resize=584%2C438\" alt=\"\" width=\"584\" height=\"438\" srcset=\"https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2021\/02\/P1010881.jpg?resize=1024%2C768&amp;ssl=1 1024w, https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2021\/02\/P1010881.jpg?resize=300%2C225&amp;ssl=1 300w, https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2021\/02\/P1010881.jpg?resize=768%2C576&amp;ssl=1 768w, https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2021\/02\/P1010881.jpg?resize=1536%2C1152&amp;ssl=1 1536w, https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2021\/02\/P1010881.jpg?resize=400%2C300&amp;ssl=1 400w, https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2021\/02\/P1010881.jpg?w=2048&amp;ssl=1 2048w, https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2021\/02\/P1010881.jpg?w=1330 1330w, https:\/\/i0.wp.com\/yobou.work\/wp-content\/uploads\/2021\/02\/P1010881.jpg?w=1995 1995w\" sizes=\"(max-width: 584px) 100vw, 584px\" 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\/>\n<\/strong>\u3000\u307e\u305a\u3001\u7d30\u83cc\u611f\u67d3\u75c7\u3068\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u611f\u67d3\u75c7\u306b\u3064\u3044\u3066\u533a\u5225\u3057\u3066\u7406\u89e3\u3057\u3066\u304a\u304b\u306a\u3051\u308c\u3070\u306a\u308a\u307e\u305b\u3093\u3002\u611f\u67d3\u75c7\u306e\u75c5\u539f\u4f53\u3092\u7279\u5b9a\u3059\u308b\u6307\u91dd\u306e\u3072\u3068\u3064\u3068\u3057\u3066\u3001\u7d30\u83cc\u5b66\u306e\u7236\u30ed\u30d9\u30eb\u30c8\u30fb\u30b3\u30c3\u30db\u306e\u63d0\u5531\u3057\u305f\u300c\u30b3\u30c3\u30db\u306e\u539f\u5247\u300d\u304c\u3042\u308a\u307e\u3059\u3002\uff11\uff0e\u7279\u5b9a\u306e\u75be\u60a3\u306b\u306f\u7279\u5b9a\u306e\u5fae\u751f\u7269\u304c\u307f\u3064\u304b\u308b\u3053\u3068\u3002\uff12\uff0e\u305d\u306e\u5fae\u751f\u7269\u3092\u5206\u96e2\u3067\u304d\u308b\u3053\u3068\u3002\uff13\uff0e\u5206\u96e2\u3057\u305f\u5fae\u751f\u7269\u3092\u611f\u53d7\u6027\u306e\u3042\u308b\u52d5\u7269\u306b\u611f\u67d3\u3055\u305b\u308b\u3068\u540c\u3058\u75c5\u6c17\u304c\u8d77\u3053\u308b\u3053\u3068\u3002\uff14\uff0e\u305d\u306e\u5fae\u751f\u7269\u304c\u305d\u306e\u75c5\u5de3\u90e8\u304b\u3089\u518d\u3073\u5206\u96e2\u3067\u304d\u308b\u3053\u3068\u3002\u3044\u308f\u3086\u308b\u3053\u308c\u3089\u6761\u4ef6\u3092\u6e80\u305f\u3059\u3082\u306e\u304c\u300c\u7d30\u83cc\u611f\u67d3\u75c7\u300d\u3067\u3059\u3002<br \/>\n\u3000\u3057\u304b\u3057\u3001\u8fd1\u5e74\u3067\u306f\u3053\u306e\u300c\u30b3\u30c3\u30db\u306e\u539f\u5247\u300d\u3092\u6e80\u305f\u3059\u5358\u7d14\u306a\u7d30\u83cc\u611f\u67d3\u75c7\u304c\u5c11\u306a\u304f\u306a\u308a\u3001\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7\u3084\u4eca\u56de\u53d6\u308a\u4e0a\u3052\u308b\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u306b\u3088\u308b\u611f\u67d3\u75c7\u304c\u5897\u52a0\u3057\u3066\u3044\u308b\u306e\u3067\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2><strong>\u30c7\u30f3\u30bf\u30eb\u30d7\u30e9\u30fc\u30af(\u6b6f\u57a2)\u3068\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u306e\u9055\u3044<\/strong><\/h2>\n<p><strong><br \/>\n<\/strong>\u3000\u300c\u30c7\u30f3\u30bf\u30eb\u30d7\u30e9\u30fc\u30af\uff08\u6b6f\u57a2\uff09\u300d\u3068\u300c\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u300d\u3092\u540c\u4e00\u306e\u3082\u306e\u3068\u7406\u89e3\u3057\u3066\u3044\u308b\u4eba\u3082\u3044\u308b\u3068\u601d\u3046\u306e\u3067\u3059\u304c\u3001\u53b3\u5bc6\u306b\u306f\u7570\u306a\u308b\u3082\u306e\u3067\u3059\u3002\u540c\u4e00\u306e\u3082\u306e\u3068\u7406\u89e3\u3057\u3066\u3057\u307e\u3046\u3068\u3001\u8aac\u660e\u3067\u304d\u306a\u3044\u90e8\u5206\u304c\u51fa\u3066\u304d\u3066\u3057\u307e\u3044\u307e\u3059\u3002\u30c7\u30f3\u30bf\u30eb\u30d7\u30e9\u30fc\u30af\u306f\u6b6f\u9762\u306b\u4ed8\u7740\u3059\u308b\u7d30\u83cc\u306e\u584a(\u6c5a\u308c\u306e\u3088\u3046\u306a\u3082\u306e)\u3068\u3044\u3046\u610f\u5473\u3067\u7528\u3044\u3089\u308c\u307e\u3059\u304c\u3001\u300c\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u300d\u306f\u3001\u305d\u308c\u3089\u3092\u69cb\u6210\u3059\u308b\u7d30\u83cc\u304c\u30af\u30aa\u30e9\u30e0\u30fb\u30bb\u30f3\u30b7\u30f3\u30b0(quorum sensing)\u3068\u547c\u3070\u308c\u308b\u60c5\u5831\u4f1d\u9054\u3092\u884c\u3046\u96c6\u56e3\u30fb\u30b3\u30df\u30e5\u30cb\u30c6\u30a3\u30fc\u3067\u3042\u308b\u3068\u3044\u3046\u7406\u89e3\u3092\u3057\u306a\u304f\u3066\u306f\u306a\u308a\u307e\u305b\u3093\u3002\u3064\u307e\u308a\u3001\u30c7\u30f3\u30bf\u30eb\u30d7\u30e9\u30fc\u30af\u306f\u5358\u306b\u69cb\u9020\u7269\u3092\u3055\u3057\u3001\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u306f\u69cb\u9020\u3067\u3042\u308a\u6a5f\u80fd\u3092\u3082\u3055\u3059\u306e\u3060\u3068\u7406\u89e3\u3057\u3066\u3088\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2><strong>\u53e3\u8154\u9818\u57df\u306e\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u611f\u67d3\u75c7<\/strong><\/h2>\n<p><strong><br \/>\n<\/strong>\u3000\u53e3\u8154\u9818\u57df\u306e\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u611f\u67d3\u75c7\u306e\u4ee3\u8868\u4f8b\u306f\u300c\u3046\u8755\u300d\u300c\u6b6f\u5468\u75c5\u300d\u300c\u53e3\u8154\u30ab\u30f3\u30b8\u30c0\u75c7\u300d\u300c\u53e3\u5185\u708e\u300d\u3067\u3059\u3002\u5b66\u6821\u3084\u304a\u52e4\u3081\u306e\u6b6f\u79d1\u533b\u9662\u3067\u3001\u99b4\u67d3\u307f\u306e\u3042\u308b\u611f\u67d3\u75c7\u3060\u3068\u601d\u3044\u307e\u3059\u3002\u53e3\u8154\u5185\u306e\u6e29\u5ea6\u3084\u6e7f\u5ea6\u306a\u3069\u306e\u6761\u4ef6\u304c\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u306e\u5897\u6b96\u306b\u9069\u3057\u3066\u3044\u308b\u3053\u3068\u304b\u3089\u300c\u6b6f\u79d1\u75be\u60a3\u306f\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u3068\u306e\u6226\u3044\u300d\u3067\u3042\u308b\u3068\u8a00\u3063\u3066\u3082\u904e\u8a00\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u53e3\u8154\u5185\u306e\u5927\u62b5\u306e\u7d30\u83cc\u306f\u5bbf\u4e3b(\u53e3\u8154\u5185)\u306b\u68f2\u307f\u3064\u3044\u3066\u3044\u306a\u304c\u3089\u3001\u901a\u5e38\u306f\u4f55\u3089\u5bb3\u3068\u306a\u308b\u3053\u3068\u304c\u306a\u3044\u5fae\u751f\u7269\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u6b6f\u306e\u78e8\u304d\u6b8b\u3057\u306a\u3069\u304c\u3042\u308b\u3068\u30c7\u30f3\u30bf\u30eb\u30d7\u30e9\u30fc\u30af\u304c\u5f62\u6210\u3055\u308c\u3001\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u3092\u5f62\u6210\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u75c5\u539f\u6027\u3092\u767a\u63ee\u3057\u307e\u3059\u3002\u307e\u305f\u7d30\u83cc\u306f\u3001\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u3092\u5f62\u6210\u3059\u308b\u3053\u3068\u3067\u74b0\u5883\u5909\u5316\u3078\u306e\u62b5\u6297\u529b\u3092\u7372\u5f97\u3057\u307e\u3059\u3002<br \/>\n\u3000\u666e\u6bb5\u306f\u3042\u307e\u308a\u60aa\u3055\u3092\u3057\u306a\u3044\u3088\u3046\u306a\u5e38\u5728\u83cc\u304c\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u3092\u5f62\u6210\u3057\u3001\u75c5\u539f\u6027\u3092\u767a\u63ee\u3057\u3066\u3057\u307e\u3046\u3088\u3046\u306a\u611f\u67d3\u75c7\u3092\u300c\u65e5\u548c\u898b(\u3072\u3088\u308a\u307f)\u611f\u67d3\u75c7\u300d\u3068\u3044\u3044\u307e\u3059\u3002\u4ee3\u8868\u7684\u306a\u4f8b\u3068\u3057\u3066\u771f\u83cc\u306e<em>C. albicans<\/em>\u306a\u3069\u306b\u3088\u308b\u30ab\u30f3\u30b8\u30c0\u75c7\u304c\u6319\u3052\u3089\u308c\u307e\u3059\u3002<em>C. 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\/>\n<\/strong>\u3000\u30c6\u30c8\u30e9\u30b5\u30a4\u30af\u30ea\u30f3\u7cfb\u306e\u5869\u9178\u30df\u30ce\u30b5\u30a4\u30af\u30ea\u30f3\u306a\u3069\u304c\u4f7f\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u8010\u6027\u83cc\u306e\u767a\u73fe\u304c\u5c11\u306a\u304f\u3001\u5b89\u5168\u6027\u3082\u9ad8\u3044\u3082\u306e\u3067\u3059\u3002<\/p>\n<p><strong>(3)<\/strong><strong>\u305d\u306e\u4ed6<br \/>\n<\/strong>\u3000IPMP\u3001\u30dd\u30d4\u30c9\u30f3\u30e8\u30fc\u30c9\u3001\u30af\u30ed\u30eb\u30d8\u30ad\u30b7\u30b8\u30f3\u30b0\u30eb\u30b3\u30f3\u9178\u5869\u6d17\u53e3\u5264(CHX)\u3001\u5869\u5316\u30bb\u30c1\u30eb\u30d4\u30ea\u30b8\u30cb\u30a6\u30e0(CPC)\u3001\u30d0\u30af\u30c6\u30ea\u30aa\u30bb\u30e9\u30d4\u30fc\uff08\u3053\u306e\u3078\u3093\u306f\u307e\u305f\u5225\u306e\u6a5f\u4f1a\u306b\u3067\u3082\u30fb\u30fb\u30fb\uff09<\/p>\n<p><!-- START MoshimoAffiliateEasyLink --><\/p>\n<p><script 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id=\"msmaflink-A9lkN\">\u00a0<\/div>\n<div>\u00a0<\/div>\n<div>\u2191\u30d3\u30b8\u30e5\u30a2\u30eb\u6b6f\u5468\u75c5\u3092\u79d1\u5b66\u3059\u308b\u3000\u5929\u91ce\u6566\u96c4\u3001\u5ca1\u8ce2\u4e8c\u3001\u6751\u4e0a\u4f38\u4e5f\u3000\u76e3\u4fee\u3000\u30af\u30a4\u30f3\u30c6\u30c3\u30bb\u30f3\u30b9\u51fa\u7248\u682a\u5f0f\u4f1a\u793e\u3000\u6b6f\u5468\u75c5\u5b66\u8005\u304b\u3089\u307f\u305f\u30c7\u30f3\u30bf\u30eb\u30d7\u30e9\u30fc\u30af\u3001\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u306b\u95a2\u3059\u308b\u66f8\u7c4d\u3067\u3059\u3002\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\uff0b\u6b6f\u5468\u75c5\u3078\u306e\u81e8\u5e8a\u7406\u89e3\u306e\u305f\u3081\u306b\u304a\u52e7\u3081\u3067\u3059\u3002<\/div>\n<div>\u00a0<\/div>\n<div>\u00a0<\/div>\n<p><!-- MoshimoAffiliateEasyLink END --><\/p>\n<h2><strong>\u307e\u3068\u3081<\/strong><\/h2>\n<p>\u30fb\u30c7\u30f3\u30bf\u30eb\u30d7\u30e9\u30fc\u30af\u3068\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u306e\u9055\u3044\u306f\u60c5\u5831\u4f1d\u9054\u306e\u6709\u7121\u3002<br \/>\n\u30fbPMTC\u306e\u76ee\u7684\u306f\u30c7\u30f3\u30bf\u30eb\u30d7\u30e9\u30fc\u30af\u3067\u306f\u306a\u304f\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u3092\u9664\u53bb\u3059\u308b\u3053\u3068\u3002<br \/>\n\u30fb\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u3092\u3069\u3046\u9664\u53bb\u3059\u308b\u304b\u3067\u306f\u306a\u304f\u3001\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u3092\u5f62\u6210\u3057\u306a\u3044\u3088\u3046\u306b\u3059\u308b\u3053\u3068\u304c\u5927\u5207<br \/>\n\u30fb\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u611f\u67d3\u75c7\u6cbb\u7642\u306e\u7b2c\u4e00\u9078\u629e\u306f\u30bb\u30eb\u30d5\u30b1\u30a2\u3001\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u306e\u6a5f\u68b0\u7684\u9664\u53bb<br \/>\n\u30fb\u6b6f\u79d1\u533b\u7642\u5f93\u4e8b\u8005\u306f\u4fee\u5fa9\u7269\u306e\u30aa\u30fc\u30d0\u30fc\u30cf\u30f3\u30b0\u3084SRP\u6642\u306e\u30ad\u30ba\u306b\u3082\u6ce8\u8996\u3059\u308b\u3002<\/p>\n<p>\u3000\u7269\u8cea\u306b\u8868\u9762\u304c\u3042\u308b\u4ee5\u4e0a\u3001\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u304c\u5f62\u6210\u3055\u308c\u3066\u3057\u307e\u3046\u306e\u306f\u3057\u3087\u3046\u304c\u306a\u3044\u3053\u3068\u3067\u3059\u3002\u300c\u5f62\u6210\u3055\u308c\u3066\u3057\u307e\u3063\u305f\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u3092\u3069\u3046\u9664\u53bb\u3059\u308c\u3070\u3088\u3044\u304b\u300d\u3067\u306f\u306a\u304f\u3001\u4e88\u9632\u306e\u6982\u5ff5\u3068\u540c\u69d8\u306b\u300c\u3067\u304d\u308b\u3060\u3051\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u3092\u5f62\u6210\u3057\u306a\u3044\u3088\u3046\u306b\u8868\u9762\u3092\u30ad\u30ec\u30a4\u306a\u72b6\u614b\u3067\u4fdd\u3064\u300d\u3068\u3044\u3046\u3053\u3068\u304c\u3082\u3063\u3068\u3082\u5927\u5207\u306a\u3053\u3068\u3067\u3059\u3002\u60a3\u8005\u3055\u3093\u81ea\u8eab\u306e\u30bb\u30eb\u30d5\u30b1\u30a2\u3084TBI\u3082\u5927\u5207\u3067\u3059\u304c\u3001\u30d7\u30ed\u306e\u76ee\u3068\u3057\u3066\u4fee\u5fa9\u7269\u306e\u30aa\u30fc\u30d0\u30fc\u30cf\u30f3\u30b0\u3084SRP\u6642\u306e\u30ad\u30ba(\u3068\u3082\u306b\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u3092\u5f62\u6210\u3057\u3084\u3059\u3044\u304b\u3089)\u306a\u3069\u306b\u3082\u6ce8\u610f\u3092\u6255\u3046\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<br \/>\n\u3000\u4eca\u56de\u306f\u30d0\u30a4\u30aa\u30d5\u30a3\u30eb\u30e0\u3092\u53d6\u308a\u4e0a\u3052\u3066\u307f\u307e\u3057\u305f\u3002\u3069\u3053\u307e\u3067\u6df1\u5800\u308a\u3059\u308c\u3070\u3088\u3044\u304b\u8ff7\u3046\u3068\u3053\u308d\u3082\u3042\u308a\u307e\u3057\u305f\u304c\u81e8\u5e8a\u5bb6\u306e\u8aad\u307f\u7269\u3068\u3057\u3066\u3001\u3055\u3089\u3063\u3068\u8aad\u3093\u3067\u3082\u3089\u3063\u3066\u53c2\u8003\u306b\u306a\u308b\u90e8\u5206\u304c\u3042\u308c\u3070\u5b09\u3057\u3044\u3067\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<h2><strong>\u53c2\u8003\u6587\u732e<\/strong><\/h2>\n<p>Yasuda, Hiroshi Trends in Glycoscience and Glycotechnology Vol.8 No.44 409-417 1996<br \/>\nAraujo MWB et al. J Am Dent Assoc.;146(8):610-622 2015<br \/>\nBoyle P, Koechlin A. Oral Dis.;20(Suppl 1):1-68 2014<br \/>\n\u672c\u5f53\u306ePMTC\u2015\u305d\u306e\u610f\u5473\u3068\u4fa1\u5024\u2015\u3000\u30da\u30fc\u30eb\u30a2\u30af\u30bb\u30eb\u30bd\u30f3\u8457\u3000\u897f\u771f\u7d00\u5b50\u8a33\u3000\u30aa\u30fc\u30e9\u30eb\u30b1\u30a2<br \/>\n\u6b6f\u5468\u75c5\u60a3\u8005\u306b\u304a\u3051\u308b\u6297\u83cc\u85ac\u9069\u6b63\u4f7f\u7528\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f32020\u3000\u65e5\u672c\u6b6f\u5468\u75c5\u5b66\u4f1a<br \/>\n\u5c0f\u5ddd\u3089\u3000\u65e5\u672c\u6b6f\u5468\u75c5\u5b66\u4f1a\u96d1\u8a8c38\u5dfb3\u53f7354-358 1996<br \/>\n\u738b\u5b9d\u79ae\u3000\u677e\u672c\u6b6f\u5b6633:157\uff5e166, 2007<br \/>\n\u30c7\u30f3\u30bf\u30eb\u30d7\u30e9\u30fc\u30af\u306e\u3059\u3079\u3066\u3000\u5965\u7530\u514b\u723e\u3000\u533b\u6b6f\u85ac\u51fa\u7248<br 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href=\"http:\/\/yobou.work\/?p=74\">TBI\u3092\u6210\u529f\u306b\u5c0e\u304f\u305f\u3081\u306b\u4eba\u306b\u884c\u52d5\u5909\u5bb9\u3092\u5373\u3059\u4e0a\u3067\u6709\u52b9\u306a\uff13\u3064\u306e\u65b9\u6cd5<\/a><\/p>\n<p>\n<a title=\"\u30d5\u30c3\u5316\u7269(\u30d5\u30c3\u7d20)\u914d\u5408\u6b6f\u78e8\u5264\u306e\u904e\u53bb\u3068\u672a\u6765\" 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