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1\/2\uff5e4\u304b\u6708\u3068\u3055\u308c\u3001\u6b6f\u51a0\u5b8c\u6210\u304c2 1\/2\uff5e3\u5e74\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4e2d\u5207\u6b6f\u306e\u5834\u5408\u3001\u6b6f\u80da\u5f62\u6210\u306f\u80ce\u751f5\uff5e5 1\/4\u6708\u3068\u3055\u308c\u3001\u6b6f\u51a0\u5b8c\u6210\u304c4\uff5e\uff15\u5e74\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4e00\u65b9\u3001\u840c\u51fa\u304c\u4e00\u756a\u9045\u3044\u7b2c\u4e8c\u5927\u81fc\u6b6f\u306e\u5834\u5408\u3001\u6b6f\u80da\u5f62\u6210\u304c8 1\/2\uff5e9\u304b\u6708\u3001\u6b6f\u51a0\u5b8c\u6210\u304c7\uff5e8\u6b73\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u3000\u78ba\u304b\u306b\uff16\u6b73\u4ee5\u4e0a\u3067\u3042\u308c\u3070\u3001\u307b\u3068\u3093\u3069\u306e\u6b6f\u7a2e\u306e\u30a8\u30ca\u30e1\u30eb\u8cea\u306f\u307b\u307c\u5b8c\u6210\u3057\u3066\u304a\u308a\u3001\u30bf\u30a4\u30df\u30f3\u30b0\u7684\u306b\u306f\u6b6f\u306e\u30d5\u30c3\u7d20\u75c7\u306b\u7f79\u60a3\u3059\u308b\u30ea\u30b9\u30af\u306f\u4f4e\u3044\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u4eee\u306b\u3001\u5c40\u6240\u5fdc\u7528\u3067\u30a8\u30ca\u30e1\u30eb\u82bd\u7d30\u80de\u306b\u969c\u5bb3\u304c\u8d77\u3053\u308b\u3068\u4eee\u5b9a\u3057\u305f\u5834\u5408\u3067\u3042\u3063\u3066\u3082\u3001\u30d5\u30c3\u5316\u7269\u3092\u98f2\u6599\u6c34\u3068\u3057\u3066\u670d\u7528\u3059\u308b\u306a\u3069\u9577\u671f\u7684\u304b\u3064\u7d99\u7d9a\u7684\u306b\u5fdc\u7528\u3059\u308b\u3053\u3068\u304c\u306a\u3044\u5c40\u6240\u5fdc\u7528\u306e\u307f\u3067\u6b6f\u306e\u30d5\u30c3\u7d20\u75c7\u304c\u8d77\u3053\u308b\u3053\u3068\u306f\u8003\u3048\u306b\u304f\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n<p>\u3000\u65e5\u672c\u53e3\u8154\u885b\u751f\u5b66\u4f1a\u7de8\u300c\u30d5\u30c3\u5316\u7269\u5fdc\u7528\u5b9f\u65bd\u30de\u30cb\u30e5\u30a2\u30eb\u300d\u3082\u3001\u30d5\u30c3\u5316\u7269\u6d17\u53e3\u3068\u6b6f\u306e\u30d5\u30c3\u7d20\u75c7\u306b\u3064\u3044\u3066\u300c\u30d5\u30c3\u5316\u7269\u6d17\u53e3\u3092\u958b\u59cb\u3059\u308b\u6642\u671f\u304c\uff14\u6b73\u3067\u3042\u3063\u3066\u3082\u3001\u6c38\u4e45\u6b6f\u306e\u6b6f\u51a0\u90e8\u306f\u3001\u307b\u307c\u3067\u304d\u3042\u304c\u3063\u3066\u3044\u308b\u306e\u3067\u3001\u6c34\u9053\u6c34\u30d5\u30ed\u30ea\u30c7\u30fc\u30b7\u30e7\u30f3\u304c\u5b9f\u65bd\u3055\u308c\u3066\u3044\u306a\u3044\u5730\u57df\u3067\u306f\u3001\u30d5\u30c3\u5316\u7269\u6d17\u53e3\u306b\u3088\u3063\u3066\u6b6f\u306e\u30d5\u30c3\u7d20\u75c7\u304c\u767a\u73fe\u3059\u308b\u3053\u3068\u306f\u3042\u308a\u307e\u305b\u3093\u300d\u3068\u8a18\u8f09\u3057\u3066\u3044\u307e\u3059\u3002\u3064\u307e\u308a\u3001\u305d\u3082\u305d\u3082\u30d5\u30c3\u5316\u7269\u306e\u53d6\u308a\u8fbc\u307f\u91cf\u304c\u5c11\u306a\u3044\u65e5\u672c\u3067\u306f\u3001\u5c40\u6240\u6295\u4e0e\u3092\u5b9f\u65bd\u3057\u3066\u3082\u6b6f\u306e\u30d5\u30c3\u7d20\u75c7\u304c\u8d77\u3053\u308b\u53ef\u80fd\u6027\u306f\u4f4e\u3044\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\u307e\u305f\u3001\u65e5\u672c\u3067\u30d5\u30c3\u5316\u7269\u306e\u5c40\u6240\u5fdc\u7528\u6cd5\u306b\u3088\u3063\u3066\u6b6f\u306e\u30d5\u30c3\u7d20\u75c7\u304c\u8d77\u3053\u3063\u305f\u3068\u3044\u3046\u5831\u544a\u306f\u898b\u3064\u304b\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2>\n\uff13\uff0e\u6b6f\u306e\u30d5\u30c3\u7d20\u75c7\u306b\u95a2\u3059\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\uff1f<\/h2>\n<p>\u3000\u6b6f\u306e\u30d5\u30c3\u7d20\u75c7\u306b\u95a2\u3059\u308b\u7814\u7a76\u306f\u6570\u591a\u304f\u3042\u308a\u307e\u3059\u3002\u4eca\u56de\u306f\u305d\u306e\u4e2d\u304b\u3089\u3001\u7dcf\u8aac\uff11\u4ef6\u3001\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc\uff12\u4ef6\u3001\u30d5\u30ed\u30ea\u30c7\u30fc\u30b7\u30e7\u30f3\u3068\u767a\u75c5\u7387\u306e\u8ad6\u6587\u3001\u30ab\u30ca\u30c0\u5c0f\u5150\u79d1\u5b66\u4f1a\u306e\u30b9\u30c6\u30fc\u30c8\u30e1\u30f3\u30c8\u306e\u8a08\uff15\u3064\u3092\u7c21\u5358\u306b\u3054\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n<p><strong>\uff08\uff11\uff09\u300c5\u6b73\u307e\u3067\u306e\u5b50\u4f9b\u306f\u3001\u6b6f\u78e8\u304d\u306e\u969b\u306b\u4f7f\u7528\u3059\u308b\u6b6f\u78e8\u304d\u7c89\u306e\u7d0430%\u3092\u98f2\u307f\u8fbc\u3093\u3067\u3057\u307e\u3046\u3002\u307e\u305f\u3001\u30d5\u30c3\u7d20\u5165\u308a\u306e\u6c34\u3092\u540c\u6642\u306b\u6442\u53d6\u3059\u308b\u3068\u6b6f\u306e\u30d5\u30c3\u7d20\u75c7\u306e\u6f5c\u5728\u7684\u306a\u30ea\u30b9\u30af\u304c\u767a\u751f\u3059\u308b\u300d<\/strong><\/p>\n<p>Abanto Alvarez J, Rezende KM, Marocho SM, Alves FB, Celiberti P, Ciamponi AL. <br \/>\nDental fluorosis: exposure, prevention and management. Med Oral Patol Oral Cir Bucal. 2009 Feb 1;14(2):E103-7.<\/p>\n<p>\u30002009\u5e74\u306b\u767a\u8868\u3055\u308c\u305f\u30d6\u30e9\u30b8\u30eb \u30b5\u30f3\u30d1\u30a6\u30ed\u5927\u5b66\u306e\u5c0f\u5150\u3068\u6b6f\u306e\u30d5\u30c3\u7d20\u75c7\u306b\u95a2\u3059\u308b\u7dcf\u8ad6\u3067\u3059\u3002\u4eca\u56de\u3001\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc\u540c\u69d8\u306b\u500b\u5225\u306e\u8ad6\u6587\u307e\u3067\u8ffd\u3063\u3066\u3044\u304d\u307e\u305b\u3093\u304c\u3001\u3088\u304f\u307e\u3068\u3081\u3089\u308c\u3066\u3044\u3066\u6b6f\u306e\u30d5\u30c3\u7d20\u75c7\u306b\u95a2\u3059\u308b\u77e5\u8b58\u3092\u6574\u7406\u3059\u308b\u306e\u306b\u5f79\u7acb\u3061\u307e\u3057\u305f\u3002<\/p>\n<p>(\u629c\u7c8b)<br \/>\n\u30fb\u3044\u3064\u3001\u3069\u306e\u304f\u3089\u3044\u306e\u671f\u9593\u30d5\u30c3\u5316\u7269\u306b\u904e\u5270\u306b\u66b4\u9732\u3055\u308c\u305f\u304b\u3001\u500b\u4eba\u306e\u53cd\u5fdc\u3001\u4f53\u91cd\u3001\u7269\u7406\u7684\u306a\u5ea6\u5408\u3044\u3001\u6804\u990a\u56e0\u5b50\u304a\u3088\u3073\u9aa8\u306e\u6210\u9577\u306b\u4f9d\u5b58\u3057\u3001\u305d\u306e\u3053\u3068\u304b\u3089\u540c\u3058\u91cf\u306e\u30d5\u30c3\u5316\u7269\u3067\u3082\u6b6f\u306e\u30d5\u30c3\u7d20\u75c7\u306e\u30ec\u30d9\u30eb\u306f\u7570\u306a\u308b\u3002<br \/>\n\u30fb\u6b6f\u306e\u30d5\u30c3\u7d20\u75c7\u306f\u751f\u5f8c20\uff5e30\u30f5\u6708\u306e\u9593\u306b\u30d5\u30c3\u5316\u7269\u306b\u904e\u5270\u306b\u3055\u3089\u3055\u308c\u305f\u5b50\u4f9b\u306b\u8d77\u3053\u308a\u3084\u3059\u3044\u6c38\u4e45\u6b6f\u5217\u306e\u5be9\u7f8e\u7684\u5909\u5316\u3002\u30d5\u30c3\u5316\u7269\u306e\u904e\u5270\u66dd\u9732\u306e\u81e8\u754c\u671f\u306f1\u6b73\u304b\u30894\u6b73\u306e\u9593\u3067\u3042\u308a\u30018\u6b73\u524d\u5f8c\u3067\u306f\u5371\u967a\u3067\u306f\u306a\u3044\u3002<br \/>\n\u30fb\u30d5\u30c3\u5316\u7269\u3092\u6dfb\u52a0\u3057\u305f\u98f2\u6599\u6c34\u3001\u30d5\u30c3\u5316\u7269\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3001\u5c40\u6240\u7684\u306a\u30d5\u30c3\u5316\u7269\u5fdc\u7528\u3001\u5b50\u4f9b\u7528\u306b\u51e6\u65b9\u3055\u308c\u305f\u7c89\u30df\u30eb\u30af\u306e\uff14\u3064\u304c\u30ea\u30b9\u30af\u56e0\u5b50\u306b\u306a\u308b\u3002<br \/>\n\u30fb\u6b6f\u306e\u767a\u80b2\u4e2d\u306b\u4f53\u5185\u3067\u4e00\u5b9a\u306e\u30d5\u30c3\u5316\u7269\u6fc3\u5ea6\u304c\u4fdd\u305f\u308c\u308b\u6642\u9593\u306b\u4f9d\u5b58\u3059\u308b\u3002\u3057\u304b\u3057\u3001\u3053\u306e\u554f\u984c\u306b\u95a2\u3059\u308b\u75ab\u5b66\u7684\u30c7\u30fc\u30bf\u306f\u6587\u732e\u306b\u4e4f\u3057\u3044\u3002<br \/>\n\u30fb8\uff5e9\u6b73\u306e\u5b50\u4f9b\u306e\u6c38\u4e45\u5207\u6b6f\u306b\u304a\u3051\u308b\u30d5\u30c3\u7d20\u75c7\u306e\u6709\u75c5\u7387\u306f\u3001\u6c34\u9053\u6c34\u30d5\u30ed\u30ea\u30c7\u30fc\u30b7\u30e7\u30f3\u5b9f\u65bd\u5730\u57df\u3068\u305d\u3046\u3067\u306a\u3044\u5730\u57df\u306e\u30d5\u30c3\u7d20\u75c7\u306e\u6709\u75c5\u7387\u306f\u3001\u305d\u308c\u305e\u308c54%\u306823\uff05\u3067\u3042\u3063\u305f\u3002<br \/>\n\u30fb\u4e95\u6238\u304b\u3089\u76f4\u63a5\u98f2\u6599\u6c34\u3092\u5f97\u3066\u3044\u308b\u5730\u57df\u3067\u306f\u3001\u6b6f\u306e\u30d5\u30c3\u7d20\u75c7\u304c\u767a\u75c7\u3057\u3066\u304a\u308a\u3001\u4e95\u6238\u304c\u6df1\u3051\u308c\u3070\u6df1\u3044\u307b\u3069\u98f2\u6599\u6c34\u306e\u30d5\u30c3\u7d20\u6fc3\u5ea6\u306f\u9ad8\u304f\u306a\u308b\u3002<br \/>\n\u30fb\u6c34\u9053\u6c34\u30d5\u30ed\u30ea\u30c7\u30fc\u30b7\u30e7\u30f3\u5730\u57df\u3067\u306f\u3001\u30d5\u30c3\u5316\u7269\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u4f7f\u7528\u306b\u3088\u308b\u6b6f\u306e\u30d5\u30c3\u7d20\u75c7\u306e\u30ea\u30b9\u30af\u306f4\u500d\u4ee5\u4e0a\u3067\u3042\u308b\u3002<br \/>\n\u30fb\u904e\u5270\u306a\u30d5\u30c3\u5316\u7269\u306e\u6442\u53d6\u306f\u3001\u30d5\u30c3\u5316\u7269\u3092\u542b\u3080\u6b6f\u78e8\u304d\u5264\u306e\u4e0d\u9069\u5207\u306a\u4f7f\u7528\u307e\u305f\u306f\u98f2\u307f\u8fbc\u307f\u306b\u3088\u308b\u3082\u306e\u3067\u3042\u308a\u3001\u6b6f\u306e\u30d5\u30c3\u7d20\u75c7\u306e\u767a\u75c7\u306e\u539f\u56e0\u3068\u306a\u308b\u3002\u4e88\u9632\u6cd5\u3068\u3057\u3066\u306f\u6b6f\u78e8\u5264\u306e\u4f7f\u7528\u91cf\u3092\u6e1b\u3089\u3057\u3001\u4f4e\u6fc3\u5ea6\u306e\u30d5\u30c3\u5316\u7269\u914d\u5408\u6b6f\u78e8\u5264(\u7d04400ppm\uff5e550ppm)\u304c\u597d\u307e\u3057\u3044\u3002\u6ce1\u72b6\u306e\u6b6f\u78e8\u5264\u306f\u6d41\u52d5\u6027\u304c\u4f4e\u304f\u3001\u5857\u5e03\u91cf\u304c\u5c11\u306a\u304f\u3066\u6e08\u3080\u305f\u3081\u3001\u3088\u308a\u5b89\u5168\u6027\u304c\u9ad8\u3044\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\n<strong>\uff08\uff12\uff09\u751f\u5f8c12\u30f6\u6708\u672a\u6e80\u306e\u5c0f\u5150\u306b\u30d5\u30c3\u5316\u7269\u914d\u5408\u6b6f\u78e8\u5264\u3092\u4f7f\u7528\u3059\u308b\u3053\u3068\u306f\u3001\u6b6f\u306e\u30d5\u30c3\u7d20\u75c7\u306e\u30ea\u30b9\u30af\u5897\u52a0\u3068\u95a2\u9023\u304c\u3042\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3068\u3044\u3046\u3001\u5f31\u304f\u4fe1\u983c\u6027\u306e\u306a\u3044\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u3042\u308b\u300212\uff5e24\u30f6\u6708\u306e\u671f\u9593\u4e2d\u306b(\u30d5\u30c3\u5316\u7269\u914d\u5408\u6b6f\u78e8\u5264\u3092)\u4f7f\u7528\u3059\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u3001\u306f\u3063\u304d\u308a\u3057\u306a\u3044\u3002<\/strong><\/p>\n<p>Wong MCM, Glenny AM, Tsang BWK, Lo ECM, Worthington HV, Marinho VCC. <br \/>\nTopical fluoride as a cause of dental fluorosis in children. Cochrane Database of Systematic Reviews 2010, Issue 1. Art. No.: CD007693.<\/p>\n<p>\u30002010\u5e74\u306e\u30b3\u30af\u30e9\u30f3\u30ec\u30d3\u30e5\u30fc\u3067\u3059\u3002\u3053\u306e\u30ec\u30d3\u30e5\u30fc\u306f\u5e7c\u5150\u306e\u30d5\u30c3\u5316\u7269\u5c40\u6240\u5fdc\u7528\u3068\u6b6f\u306e\u30d5\u30c3\u7d20\u75c7\u306e\u95a2\u4fc2\u3092\u8ad6\u3058\u3066\u3044\u307e\u3059\u3002<br \/>\n\u751f\u5f8c12\u30f6\u6708\u4ee5\u964d\u306e\u5e7c\u5150\u306e\u6b6f\u3092\u30d5\u30c3\u5316\u7269\u914d\u5408\u6b6f\u78e8\u5264\u3067\u78e8\u304d\u59cb\u3081\u305f\u5834\u5408\u3001\u6b6f\u306e\u30d5\u30c3\u7d20\u75c7\u306e\u767a\u75c7\u306f\u7d71\u8a08\u5b66\u7684\u306b\u6709\u610f\u306b\u4f4e\u304b\u3063\u305f\u3002\u30d5\u30c3\u5316\u7269\u914d\u5408\u6b6f\u78e8\u5264\u306b\u3088\u308b\u6b6f\u78e8\u304d\u306e\u958b\u59cb\u6642\u671f\u304c\u751f\u5f8c24\u30f6\u6708\u4ee5\u524d\u304b\u4ee5\u5f8c\u304b\u3067\u306f\u3001\u6b6f\u306e\u30d5\u30c3\u7d20\u75c7\u306e\u767a\u75c7\u306f\u7d71\u8a08\u5b66\u7684\u306b\u6709\u610f\u306a\u95a2\u9023\u304c\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u3002\u8907\u6570\u306eRCT\u3067\u306f\u3001\u9ad8\u6fc3\u5ea6\u306e\u30d5\u30c3\u5316\u7269\u306e\u4f7f\u7528\u304c\u6b6f\u306e\u30d5\u30c3\u7d20\u75c7\u306e\u30ea\u30b9\u30af\u5897\u52a0\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u304c\u3001\u6b6f\u78e8\u304d\u306e\u983b\u5ea6\u304a\u3088\u3073\u30d5\u30c3\u5316\u7269\u914d\u5408\u6b6f\u78e8\u5264\u306e\u91cf\u3068\u6b6f\u306e\u30d5\u30c3\u7d20\u75c7\u3068\u306e\u9593\u306b\u306f\u6709\u610f\u306a\u95a2\u9023\u304c\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u3002\u3000<br \/>\n\u3000\u3046\u8755\u4e88\u9632\u306b\u304a\u3051\u308b\u30d5\u30c3\u5316\u7269\u5c40\u6240\u5fdc\u7528\u306e\u30e1\u30ea\u30c3\u30c8\u3068\u6b6f\u306e\u30d5\u30c3\u7d20\u75c7\u306e\u767a\u73fe\u30ea\u30b9\u30af\u306f\u30d0\u30e9\u30f3\u30b9\u3092\u8003\u616e\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002\u751f\u5f8c12\u30f6\u6708\u672a\u6e80\u306e\u5c0f\u5150\u306b\u30d5\u30c3\u5316\u7269\u914d\u5408\u6b6f\u78e8\u5264\u3092\u4f7f\u7528\u3059\u308b\u3053\u3068\u306f\u6b6f\u306e\u30d5\u30c3\u7d20\u75c7\u306e\u30ea\u30b9\u30af\u5897\u52a0\u3068\u95a2\u9023\u304c\u3042\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u5f31\u304f\u4fe1\u983c\u6027\u306e\u306a\u3044\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u307f\u3089\u308c\u305f\u300212\uff5e24\u30f6\u6708\u306e\u671f\u9593\u4e2d\u306b\u4f7f\u7528\u3059\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u3001\u306f\u3063\u304d\u308a\u3057\u306a\u3044\u3002\u3082\u3057\u6b6f\u306e\u30d5\u30c3\u7d20\u75c7\u306e\u30ea\u30b9\u30af\u304c\u5fc3\u914d\u3067\u3042\u308c\u3070\uff086\u6b73\u672a\u6e80\u306e\uff09\u5e7c\u5150\u306e\u6b6f\u78e8\u5264\u306e\u30d5\u30c3\u5316\u7269\u6fc3\u5ea6\u30921,000ppm\u672a\u6e80\u306b\u3059\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u308b\u3002\u3068\u7d50\u8ad6\u3065\u3051\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\uff08\uff13\uff09\u300c\u5e7c\u5150\u306b\u5bfe\u3059\u308b\u30d5\u30c3\u5316\u7269\u914d\u5408\u6b6f\u78e8\u5264\u306e\u6fc3\u5ea6\u306e\u9078\u629e\u306f\u3001\u6b6f\u306e\u30d5\u30c3\u7d20\u75c7\u306e\u30ea\u30b9\u30af\u3068\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u8003\u616e\u3059\u3079\u304d\u3067\u3042\u308b\u300d<\/strong><\/p>\n<p>Walsh T, Worthington HV, Glenny AM, Marinho VCC, Jeroncic A. <br \/>\nFluoride toothpastes of different concentrations for preventing dental caries. Cochrane Database of Systematic Reviews 2019, Issue 3. Art. No.: CD007868.<\/p>\n<p>\u30002019\u5e74\u306e\u30b3\u30af\u30e9\u30f3\u30ec\u30d3\u30e5\u30fc\u3067\u3059\u3002\u3053\u306e\u30ec\u30d3\u30e5\u30fc\u306f\u30d5\u30c3\u5316\u7269\u914d\u5408\u6b6f\u78e8\u5264\u306f\u6fc3\u5ea6\u304c\u9ad8\u3044\u307b\u3069\u3046\u8755\u4e88\u9632\u306b\u52b9\u679c\u7684\u3067\u3042\u308b\u3068\u3044\u3046\u30ec\u30d3\u30e5\u30fc\u3067\u3042\u3063\u3066\u3001\u76f4\u63a5\u7684\u306b\u6b6f\u306e\u30d5\u30c3\u7d20\u75c7\u306e\u30ec\u30d3\u30e5\u30fc\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u30d5\u30c3\u5316\u7269\u914d\u5408\u6b6f\u78e8\u5264\u306e\u6709\u5bb3\u4f5c\u7528\u3092\u8a55\u4fa1\u3057\u305f\u7814\u7a76\u306f\u5c11\u6570\u3067\u3001\u5831\u544a\u3055\u308c\u305f\u5834\u5408\u3067\u3042\u3063\u3066\u3082\u8edf\u7d44\u7e54\u306e\u640d\u50b7\u3084\u6b6f\u306e\u7740\u8272\u306a\u3069\u306e\u5f71\u97ff\u306f\u6700\u5c0f\u9650\u3067\u3042\u3063\u305f\u3002\u3068\u8a18\u8f09\u3055\u308c\u3066\u3044\u308b\u3088\u3046\u306b\u300c\u6fc3\u5ea6\u304c\u9ad8\u3051\u308c\u3070\u9ad8\u3044\u307b\u3069\u3044\u3044\u3088\u3068\u3044\u3046\u306e\u3067\u306f\u306a\u304f\u3001\u5e7c\u5150\u306e\u5834\u5408\u306f\u30ea\u30b9\u30af\u3082\u8003\u616e\u3057\u3066\u306d\u300d\u3068\u3044\u3046\u3053\u3068\u3067\u3042\u3063\u3066\u3001\u3053\u306e\u30ec\u30d3\u30e5\u30fc\u306b\u3088\u3063\u3066\u30d5\u30c3\u5316\u7269\u914d\u5408\u6b6f\u78e8\u5264\u306f\u6b6f\u306e\u30d5\u30c3\u7d20\u75c7\u306e\u539f\u56e0\u306b\u306a\u308b\u3068\u3044\u3046\u3053\u3068\u3092\u8a3c\u660e\u3057\u305f\u3082\u306e\u3067\u306f\u306a\u3044\u306e\u3067\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\uff08\uff14\uff09\u300c\u3046\u8755\u3068\u6b6f\u306e\u30d5\u30c3\u7d20\u75c7\u306e\u9069\u5207\u306a\u30c8\u30ec\u30fc\u30c9\u30aa\u30d5\u306f\u30010.7 ppm F\u4ed8\u8fd1\u3067\u8d77\u3053\u308b\u300d<\/strong><\/p>\n<p>Heller KE, Eklund SA, Burt BA. <br \/>\nDental caries and dental fluorosis at varying water fluoride concentrations. J Public Health Dent. 1997 Summer;57(3):136-43.<\/p>\n<p>\u3000\u672c\u7814\u7a76\u306f1986\uff5e87\u5e74\u306b\u5b9f\u65bd\u3055\u308c\u305f\u7c73\u56fd\u5b66\u7ae5\u306e\u8abf\u67fb\u30c7\u30fc\u30bf\u3092\u7528\u3044\u305f\u5927\u898f\u6a21\u306a\u7814\u7a76(n=18,755)\u3067\u3001\u6c34\u9053\u6c34\u30d5\u30ed\u30ea\u30c7\u30fc\u30b7\u30e7\u30f3\u3068\u6b6f\u306e\u30d5\u30c3\u7d20\u75c7\u306e\u91cd\u8981\u306a\u7814\u7a76\u3060\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u73fe\u5728\u3001\u65e5\u672c\u3067\u6c34\u9053\u6c34\u30d5\u30ed\u30ea\u30c7\u30fc\u30b7\u30e7\u30f3\u306f\u5b9f\u65bd\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u304c\u3001\u6b6f\u306e\u30d5\u30c3\u7d20\u75c7\u3068\u6c34\u9053\u6c34\u30d5\u30ed\u30ea\u30c7\u30fc\u30b7\u30e7\u30f3\u3092\u5225\u306b\u3057\u3066\u8003\u3048\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002\u30d5\u30c3\u5316\u7269\u306e\u98f2\u6599\u6c34\u6fc3\u5ea6\u304c0\u304b\u30890.7ppmF\u306b\u5897\u52a0\u3059\u308b\u3068\u3046\u8755\u7b49\u304c\u6025\u6fc0\u306b\u6e1b\u5c11\u3057\u305f\u304c\u30010.7ppmF\u4ee5\u4e0a\u3060\u3068\u8ffd\u52a0\u7684\u306a\u52b9\u679c\u306f\u307b\u3068\u3093\u3069\u5f97\u3089\u308c\u306a\u304b\u3063\u305f\u3002<br \/>\n\u3000\u6b6f\u306e\u30d5\u30c3\u7d20\u75c7\u306e\u6709\u75c5\u7387\u306f\u6c34\u9053\u6c34\u4e2d\u30d5\u30c3\u7d20\u6fc3\u5ea6\u304c0.3ppmF\u306713.5%\u3060\u3063\u305f\u304c\u30010.3\uff5e0.7ppm\u672a\u6e80\u306721.7%\u30010.7\uff5e1.2ppmF\u672a\u6e80\u306729.9%\u30011.2ppmF\u4ee5\u4e0a\u306741.4%\u3068\u6fc3\u5ea6\u3068\u3068\u3082\u306b\u5897\u52a0\u3057\u305f\u3002\u30d5\u30c3\u5316\u7269\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u4f7f\u7528\u306f\u30d5\u30c3\u7d20\u75c7\u306e\u5897\u52a0\u3092\u72a0\u7272\u306b\u3057\u3066\u3001\u3046\u8755\u3092\u3055\u3089\u306b\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u306b\u95a2\u9023\u3057\u3066\u3044\u305f\u3002\u3046\u8755\u3068\u30d5\u30c3\u7d20\u75c7\u306e\u9069\u5207\u306a\u30c8\u30ec\u30fc\u30c9\u30aa\u30d5\u306f0.7ppm\u7a0b\u5ea6\u3060\u3063\u305f\u3002\u3068\u3044\u3046\u5185\u5bb9\u3067\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\uff08\uff15\uff09\u300c\u88dc\u52a9\u7684\u306a\u30d5\u30c3\u5316\u7269(\u6d17\u53e3\u5264\u3084\u30c8\u30ed\u30fc\u30c1)\u306f\u751f\u5f8c6\u30f5\u6708\u304b\u3089\u306e\u307f\u6295\u4e0e\u3055\u308c\u308b\u3079\u304d\u300d<\/strong><\/p>\n<p>The use of fluoride in infants and children<br \/>\nJ Godel; Canadian Paediatric Society, Nutrition and Gastroenterology Committee Paediatr Child Health 2002;7(8):569-72<\/p>\n<p>\u3000\u65e5\u672c\u3088\u308a\u3082\u30d5\u30c3\u5316\u7269\u306b\u5bfe\u3059\u308b\u95a2\u5fc3\u304c\u9ad8\u304f\u3001\u5ea6\u3005\u30b9\u30c6\u30fc\u30c8\u30e1\u30f3\u30c8\u304c\u767a\u8868\u3055\u308c\u3066\u3044\u308b\u30ab\u30ca\u30c0\u3002\u5168\u5dde\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u30ab\u30ca\u30c0\u3067\u306f\u30d5\u30ed\u30ea\u30c7\u30fc\u30b7\u30e7\u30f3\u304c\u5b9f\u65bd\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u672c\u30b9\u30c6\u30fc\u30c8\u30e1\u30f3\u30c8\u306f\u30ab\u30ca\u30c0\u5c0f\u5150\u79d1\u5b66\u4f1a\u306b\u3088\u308b2002\u5e74\u306e\u30b9\u30c6\u30fc\u30c8\u30e1\u30f3\u30c8\u3067\u3059(2019\u306bReaffirmed\u3055\u308c\u3066\u3044\u307e\u3059)\u3002\u30ab\u30ca\u30c0\u6b6f\u79d1\u533b\u5e2b\u4f1a\uff08CDA\uff09\u3067\u306f\u306a\u304f\u30ab\u30ca\u30c0\u5c0f\u5150\u79d1\u5b66\u4f1a(CPS)\u767a\u8868\u306e\u30b9\u30c6\u30fc\u30c8\u30e1\u30f3\u30c8\u3067\u3059(\u672c\u30b9\u30c6\u30fc\u30c8\u30e1\u30f3\u30c8\u306fCDA\u306e\u58f0\u660e\u3068\u5bfe\u7acb\u3059\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093)\u3002\u6c34\u9053\u6c34\u30d5\u30ed\u30ea\u30c7\u30fc\u30b7\u30e7\u30f3\u3092\u5b9f\u65bd\u3057\u3066\u3044\u308b\u30ab\u30ca\u30c0\u306a\u3089\u3067\u306f\u306e\u3001\u3088\u308a\u5177\u4f53\u7684\u306a\u30b9\u30c6\u30fc\u30c8\u30e1\u30f3\u30c8\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>(\u629c\u7c8b)<br \/>\n\u30fb\u30d5\u30c3\u5316\u7269\u306f\u81ea\u7136\u6fc3\u5ea6\u304c0.3ppm\u672a\u6e80\u3067\u3042\u308b\u81ea\u6cbb\u4f53\u306e\u6c34\u9053\u6c34\u306b\u6dfb\u52a0\u3055\u308c\u308b\u3079\u304d\u3067\u3042\u308b\u3002<br \/>\n\u30fb\u866b\u6b6f\u3068\u30d5\u30c3\u7d20\u75c7\u306e\u9593\u306e\u30c8\u30ec\u30fc\u30c9\u30aa\u30d5\u306f0.7ppm\u4ed8\u8fd1\u3067\u3042\u308b\u3002<br \/>\n\u30fb\u30d5\u30c3\u5316\u7269\u6fc3\u5ea6\u306e\u8868\u793a\u306f\u6b6f\u78e8\u304d\u7c89\u306e\u30c1\u30e5\u30fc\u30d6\u306b\u5370\u5237\u3055\u308c\u7d9a\u3051\u308b\u3079\u304d\u3067\u3042\u308a\u3001\u6b6f\u78e8\u304d\u7c89\u306e\u4f7f\u7528\u91cf\u304c\u793a\u3055\u308c\u308b\u3079\u304d\u3067\u3042\u308b\u3002<br \/>\n\u30fb\u30d5\u30c3\u5316\u7269\u3092\u542b\u3080\u3059\u3079\u3066\u306e\u98df\u54c1\u307e\u305f\u306f\u98f2\u6599\u306b\u306f\u3001\u30d5\u30c3\u5316\u7269\u6fc3\u5ea6\u304c\u8a18\u8f09\u3055\u308c\u308b\u3079\u304d\u3067\u3042\u308b\u3002<br \/>\n\u30fb\u5b50\u4f9b\u306f\u300c\u8c46\u7c92\u5927\u300d\u306e\u91cf\u306e\u6b6f\u78e8\u304d\u7c89\u3060\u3051\u3092\u4f7f\u7528\u3057\u3001\u4f59\u5206\u306a\u3082\u306e\u3092\u98f2\u307f\u8fbc\u307e\u306a\u3044\u3088\u3046\u306b\u3059\u308b\u3002<br \/>\n\u30fb\u30d5\u30c3\u5316\u7269\u306e\u4f5c\u7528\u306f\u5c40\u6240\u7684\u306a\u3082\u306e\u3067\u3042\u308b\u305f\u3081\u3001\u6b6f\u304c\u751f\u3048\u3066\u304f\u308b\u524d\u306b\u30d5\u30c3\u5316\u7269\u3092\u4e0e\u3048\u3066\u306f\u306a\u3089\u306a\u3044\u3002<br \/>\n\u30fb\u88dc\u52a9\u7684\u306a\u30d5\u30c3\u5316\u7269\u306f\u751f\u5f8c6\u30f5\u6708\u304b\u3089\u306e\u307f\u6295\u4e0e\u3055\u308c\u308b\u3079\u304d\u3067\u3042\u308a\u3001\u305d\u308c\u306f\u4ee5\u4e0b\u306e\u6761\u4ef6\u304c\u6e80\u305f\u3055\u308c\u3066\u3044\u308b\u5834\u5408\u306b\u9650\u3089\u308c\u308b\u3002<br \/>\n\u3000\u30fb\u98f2\u6599\u6c34\u306e\u30d5\u30c3\u5316\u7269\u306e\u6fc3\u5ea6\u304c0.3ppm\u672a\u6e80\u3067\u3042\u308b\u5834\u5408\u3002<br \/>\n\u3000\u30fb\u5b50\u4f9b\u304c\u5c11\u306a\u304f\u3068\u30821\u65e52\u56de\u306e\u6b6f\u78e8\u304d\u3092\u3057\u3066\u3044\u306a\u3044\uff08\u307e\u305f\u306f\u4fdd\u8b77\u8005\u306b\u6b6f\u78e8\u304d\u3092\u3057\u3066\u3082\u3089\u3063\u3066\u3044\u306a\u3044\uff09\u5834\u5408\u3002<br \/>\n\u3000\u30fb\u6b6f\u79d1\u533b\u5e2b\u307e\u305f\u306f\u4ed6\u306e\u533b\u7642\u5c02\u9580\u5bb6\u306e\u5224\u65ad\u3067\u3001\u5b50\u4f9b\u306e\u3046\u8755\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u5834\u5408\u3002<\/p>\n<h2>\u00a0<\/h2>\n<h2>\n\uff14\uff0eQ&amp;A<\/h2>\n<p><strong>Q\uff11 \u65e5\u672c\u3067\u6b6f\u306e\u30d5\u30c3\u7d20\u75c7\u304c\u8d77\u3053\u3063\u305f\u3053\u3068\u306f\u3042\u308a\u307e\u3059\u304b\uff1f<\/strong><br \/>\n\u3000\u4eba\u70ba\u7684\u306b\u30d5\u30c3\u5316\u7269\u3092\u6dfb\u52a0\u3057\u767a\u751f\u3057\u305f\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u6c34\u6e90\u3084\u4e95\u6238\u6c34\u306a\u3069\u306b\u542b\u307e\u308c\u3066\u3044\u305f\u30d5\u30c3\u7d20\u3092\u539f\u56e0\u3068\u3057\u30661925\u5e74\u306b\u798f\u4e95\u3067\u5831\u544a\u3055\u308c\u3066\u4ee5\u6765\uff0c\u5bae\u57ce\u770c\u3092\u9664\u304f46\u90fd\u9053\u5e9c\u770c\u3067\u8abf\u67fb\u5831\u544a\u304c\u3042\u308a\u307e\u3059\uff0e1971\u5e74\u306b\u5831\u544a\u3055\u308c\u305f\u516d\u7532\u5c71\u7cfb\u306e\u6c34\u6e90\u3092\u539f\u56e0\u3068\u3057\u305f\u5175\u5eab\u770c\u5b9d\u585a\u5e02\u306e\u6b6f\u306e\u30d5\u30c3\u7d20\u75c7\u306f\u6709\u540d\u3067\u3059\uff0e\u73fe\u5728\u3067\u306f\u6c34\u9053\u304c\u53b3\u3057\u304f\u7ba1\u7406\u3055\u308c\u3066\u3044\u308b\u305f\u3081\uff0c1980\u5e74\u4ee3\u3092\u6700\u5f8c\u306b\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u305b\u3093\uff0e<\/p>\n<p><strong>Q\uff12 \u5c40\u6240\u5fdc\u7528\u3067\u6b6f\u306e\u30d5\u30c3\u7d20\u75c7\u304c\u8d77\u3053\u3063\u305f\u3068\u3044\u3046\u5831\u544a\u306f\u3042\u308a\u307e\u3059\u304b\uff1f<\/strong><br \/>\n\u3000\u56fd\u5185\u5916\u306e\u6587\u732e\u3092\u691c\u7d22\u3057\u307e\u3057\u305f\u304c\u3001\u5c40\u6240\u5fdc\u7528\u5358\u72ec\u3067\u6b6f\u306e\u30d5\u30c3\u7d20\u75c7\u304c\u767a\u751f\u3057\u305f\u3068\u3044\u3046\u5831\u544a\u306f\u898b\u3064\u3051\u308b\u3053\u3068\u304c\u51fa\u6765\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n<p><strong>Q\uff13 \u30a4\u30f3\u30c9\u3067\u6b6f\u306e\u30d5\u30c3\u7d20\u75c7\u304c\u591a\u3044\u306e\u306f\u306a\u305c\u3067\u3059\u304b\uff1f<\/strong><br \/>\n\u3000\u30a4\u30f3\u30c9\u3067\u6b6f\u306e\u30d5\u30c3\u7d20\u75c7\u304c\u591a\u3044\u306e\u306f\u9ad8\u6fc3\u5ea6\u306e\u30d5\u30c3\u7d20\u304c\u542b\u307e\u308c\u308b\u5730\u4e0b\u6c34\u306e\u5229\u7528\u3084\u5ca9\u5869\u306e\u6442\u53d6\u306b\u3088\u308b\u5f71\u97ff\u3067\u3059\u3002<\/p>\n<p><strong>Q\uff14 \uff16\u6b73\u4ee5\u4e0b\u306e\u5b50\u4f9b\u306b\u30d5\u30c3\u5316\u7269\u914d\u5408\u6b6f\u78e8\u5264\u3084\u30d5\u30c3\u7d20\u6d17\u53e3\u306f\u5371\u967a\u3067\u3059\u304b\uff1f<\/strong><br \/>\n\u3000\u30d5\u30c3\u5316\u7269\u306e\u53d6\u308a\u8fbc\u307f\u91cf\u304c\u305d\u3082\u305d\u3082\u5c11\u306a\u3044\u65e5\u672c\u3067\u306f\u3001\u5c40\u6240\u5fdc\u7528\u3067\u6b6f\u306e\u30d5\u30c3\u7d20\u75c7\u306b\u306a\u308b\u3053\u3068\u306f\u8003\u3048\u306b\u304f\u3044\u3067\u3059\u3002<br \/>\n\u3000\u3057\u304b\u3057\u3001\u591a\u304f\u306e\u8ad6\u6587\u3067\u4e0d\u8981\u306a\u30d5\u30c3\u5316\u7269\u306e\u53d6\u308a\u8fbc\u307f\u3092\u6e1b\u3089\u3059\u3088\u3046\u52e7\u544a\u3057\u3066\u304a\u308a\u3001\u6b6f\u78e8\u5264\u306e\u91cf\u3092\u6e1b\u3089\u3057\u305f\u308a\u3001\u5e74\u9f62\u306b\u5408\u3046\u30d5\u30c3\u5316\u7269\u6fc3\u5ea6\u306e\u6b6f\u78e8\u5264\u3092\u4f7f\u7528\u3057\u305f\u308a\u3001\u9069\u5207\u306a\u91cf\u306e\u30d5\u30c3\u7d20\u6d17\u53e3\u5264\u3092\u4f7f\u7528\u3059\u308b\u307b\u3046\u304c\u3088\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n<p><strong>Q\uff15 \u6d77\u5916\u3067\u306f\u65e5\u672c\u3067\u884c\u308f\u308c\u3066\u3044\u308b\u30d5\u30c3\u5316\u7269\u88fd\u5264\u306e\u4ed6\u306b\u3069\u3093\u306a\u88fd\u5264\u304c\u3042\u308a\u307e\u3059\u304b\uff1f<\/strong><br \/>\n\u3000\u4e00\u90e8\u306e\u56fd\u3067\u306f\u6c34\u9053\u6c34\u30d5\u30ed\u30ea\u30c7\u30fc\u30b7\u30e7\u30f3\u304c\u5b9f\u65bd\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u6d77\u5916\u3067\u306f\u30d5\u30c3\u5316\u7269\u914d\u5408\u30ac\u30e0\u3001\u30d5\u30c3\u5316\u7269\u914d\u5408\u30bf\u30d6\u30ec\u30c3\u30c8\u304c\u8ca9\u58f2\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30ab\u30ea\u30a8\u30b9\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u4eba\u306b\u306f5,000ppm\u306e\u6b6f\u78e8\u304d\u7c89\u304c\u51e6\u65b9\u3055\u308c\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<h2>\uff15\uff0e\u307e\u3068\u3081<\/h2>\n<p>\n\u3000\u8272\u3005\u306a\u8ad6\u6587\u691c\u7d22\u306b\u3088\u308b\u500b\u4eba\u7684\u304b\u3064\u4e3b\u89b3\u7684\u306a\u307e\u3068\u3081\u3067\u3059\u3002<\/p>\n<p>\n<strong>\u6b6f\u306e\u30d5\u30c3\u7d20\u75c7\u306e\u30ea\u30b9\u30af\u306b\u3064\u3044\u3066<\/strong><br \/>\n\u30fb 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Research progress in the last 5 years.<br \/>\nJ Cell Mol Med. 2019;23(4):2333-2342.<\/p>\n<p>Abanto Alvarez J, Rezende KM, Marocho SM, Alves FB, Celiberti P, Ciamponi AL.<br \/>\nDental fluorosis: exposure, prevention and management. <br \/>\nMed Oral Patol Oral Cir Bucal. 2009 Feb 1;14(2):E103-7.<\/p>\n<p>Wong MCM, Glenny AM, Tsang BWK, Lo ECM, Worthington HV, Marinho VCC. <br \/>\nTopical fluoride as a cause of dental fluorosis in children. <br \/>\nCochrane Database of Systematic Reviews 2010, Issue 1. 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No.: CD007868.<\/p>\n<p>Heller KE, Eklund SA, Burt BA. <br \/>\nDental caries and dental fluorosis at varying water fluoride concentrations. <br \/>\nJ Public Health Dent. 1997 Summer;57(3):136-43.<\/p>\n<p>Canadian Paediatric Society,<br \/>\nThe use of fluoride in infants and children.<br \/>\nPaediatr Child Health. 2002; 7(8):569-582.<\/p>\n<p>Del Bello L. <br \/>\nFluorosis: an ongoing challenge for India.<br \/>\nLancet Planet Health. 2020; 4(3): e94-e95.<\/p>\n<p>\u65e5\u672c\u53e3\u8154\u885b\u751f\u5b66\u4f1a \u30d5\u30c3\u5316\u7269\u5fdc\u7528\u59d4\u54e1\u4f1a\u7de8<br \/>\n\u3046\u8755\u4e88\u9632\u306e\u5b9f\u969b\u30d5\u30c3\u5316\u7269\u5c40\u6240\u5fdc\u7528\u5b9f\u65bd\u30de\u30cb\u30e5\u30a2\u30eb \u793e\u4f1a\u4fdd\u967a\u7814\u7a76\u6240<\/p>\n<p>\u5b9d\u585a\u5e02\u6c34\u9053\u6c34\u30d5\u30c3\u7d20\u6fc3\u5ea6\u306e\u7d4c\u5e74\u7684\u63a8\u79fb\u3068\u6591\u72b6\u6b6f\u30fb\u3080\u3057\u6b6f\u306e\u306a\u3044\u8005\u306e\u5272\u5408\u306e\u95a2\u4fc2<br 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